Search Results - "Thodeti, Charles K."

The role of TRPV4 channels in ocular function and pathologies by Guarino, Brianna D., Paruchuri, Sailaja, Thodeti, Charles K.

“…Transient potential receptor vanilloid 4 (TRPV4) is an ion channel responsible for sensing osmotic and mechanical signals, which in turn regulates calcium…”
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TRPV4 deletion protects heart from myocardial infarction-induced adverse remodeling via modulation of cardiac fibroblast differentiation by Adapala, Ravi K., Kanugula, Anantha K., Paruchuri, Sailaja, Chilian, William M., Thodeti, Charles K.

“…Cardiac fibrosis caused by adverse cardiac remodeling following myocardial infarction can eventually lead to heart failure. Although the role of soluble…”
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Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis by Duah, Ernest, Teegala, Lakshminarayan Reddy, Kondeti, Vinay, Adapala, Ravi K., Keshamouni, Venkateshwar G., Kanaoka, Yoshihide, Austen, K. Frank, Thodeti, Charles K., Paruchuri, Sailaja

“…Cysteinyl leukotrienes (cys-LTs) are proinflammatory mediators that enhance vascular permeability through distinct receptors (CysLTRs). We found that CysLT₂R…”
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Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity by Kanugula, Anantha K., Adapala, Ravi K., Jamaiyar, Anurag, Lenkey, Nina, Guarino, Brianna D., Liedtke, Wolfgang, Yin, Liya, Paruchuri, Sailaja, Thodeti, Charles K.

“…Transient receptor potential vanilloid 4 (TRPV4) is a ubiquitously expressed polymodally activated ion channel. TRPV4 has been implicated in tumor progression;…”
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Actomyosin Tension Exerted on the Nucleus through Nesprin-1 Connections Influences Endothelial Cell Adhesion, Migration, and Cyclic Strain-Induced Reorientation by Chancellor, T.J., Lee, Jiyeon, Thodeti, Charles K., Lele, Tanmay

“…Endothelial cell polarization and directional migration is required for angiogenesis. Polarization and motility requires not only local cytoskeletal remodeling…”
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TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling by Thodeti, Charles K, Matthews, Benjamin, Ravi, Arvind, Mammoto, Akiko, Ghosh, Kaustabh, Bracha, Abigail L, Ingber, Donald E

“…Cyclic mechanical strain produced by pulsatile blood flow regulates the orientation of endothelial cells lining blood vessels and influences critical processes…”
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Mechanosensitive TRPV4 channels stabilize VE-cadherin junctions to regulate tumor vascular integrity and metastasis by Cappelli, Holly C., Kanugula, Anantha K., Adapala, Ravi K., Amin, Vibhatsu, Sharma, Priya, Midha, Priya, Paruchuri, Sailaja, Thodeti, Charles K.

“…The transient receptor potential vanilloid 4 (TRPV4) channel is a mechanosensor in endothelial cells (EC) that regulates cyclic strain-induced reorientation…”
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Novel noncanonical regulation of soluble VEGF/VEGFR2 signaling by mechanosensitive ion channel TRPV4 by Kanugula, Anantha K., Adapala, Ravi K., Midha, Priya, Cappelli, Holly C., Meszaros, J. Gary, Paruchuri, Sailaja, Chilian, William M., Thodeti, Charles K.

“…ABSTRACT VEGF signaling via VEGF receptor‐2 (VEGFR2) is a major regulator of endothelial cell (EC) functions, including angiogenesis. Although most studies of…”
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Mechanosensitive transient receptor potential vanilloid 4 regulates Dermatophagoides farinae–induced airway remodeling via 2 distinct pathways modulating matrix synthesis and degradation by Gombedza, Farai, Kondeti, Vinay, Al‐Azzam, Nosayba, Koppes, Stephanie, Duah, Ernest, Patil, Prachi, Hexter, Madison, Phillips, Daniel, Thodeti, Charles K., Paruchuri, Sailaja

“…Contributions of mechanical signals to airway remodeling during asthma are poorly understood. Transient receptor potential vanilloid 4 (TRPV4), a…”
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Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell–dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3 by Kondeti, Vinay, PhD, Al-Azzam, Nosayba, MS, Duah, Ernest, MS, Thodeti, Charles K., PhD, Boyce, Joshua A., MD, Paruchuri, Sailaja, PhD

“…Background Although arachidonic acid metabolites, cysteinyl leukotrienes (cys-LTs; leukotriene [LT] C4 , LTD4 , and LTE4 ), and prostaglandin (PG) E2 are…”
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Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro by Ghosh, Kaustabh, Thodeti, Charles K, Dudley, Andrew C, Mammoto, Akiko, Klagsbrun, Michael, Ingber, Donald E

“…Tumor blood vessels exhibit abnormal structure and function that cause disturbed blood flow and high interstitial pressure, which impair delivery of…”
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TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation by Thoppil, Roslin J., Adapala, Ravi K., Cappelli, Holly C., Kondeti, Vinay, Dudley, Andrew C., Gary Meszaros, J., Paruchuri, Sailaja, Thodeti, Charles K.

“…Endothelial cell proliferation is a critical event during angiogenesis, regulated by both soluble factors and mechanical forces. Although the proliferation of…”
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Leukotriene D4 Upregulates Oxidized Low-Density Lipoprotein Receptor 1 and CD36 to Enhance Oxidized LDL Uptake and Phagocytosis in Macrophages Through Cysteinyl Leukotriene Receptor 1 by Pokhrel, Sabita, Gudneppanavar, Ravindra, Teegala, Lakshminarayan Reddy, Duah, Ernest, Thodeti, Charles K., Paruchuri, Sailaja

“…Endothelial permeability, leukocyte attachment, and unregulated oxidized LDL (oxLDL) uptake by macrophages leading to the formation of foam cells are all vital…”
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TRPV4 Mechanotransduction in Fibrosis by Adapala, Ravi K, Katari, Venkatesh, Teegala, Lakshminarayan Reddy, Thodeti, Sathwika, Paruchuri, Sailaja, Thodeti, Charles K

“…Fibrosis is an irreversible, debilitating condition marked by the excessive production of extracellular matrix and tissue scarring that eventually results in…”
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Angiotensin II induces endothelial dysfunction and vascular remodeling by downregulating TRPV4 channels by Kondapalli, Narendra Babu, Katari, Venkatesh, Dalal, Kesha, Paruchuri, Sailaja, Thodeti, Charles K

“…Angiotensin II (Ang II) is a potent vasoconstrictor of vascular smooth muscle cells (VSMC) and is implicated in hypertension, but it's role in the regulation…”
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Absence of Type VI Collagen Paradoxically Improves Cardiac Function, Structure, and Remodeling After Myocardial Infarction by Luther, Daniel J, Thodeti, Charles K, Shamhart, Patricia E, Adapala, Ravi K, Hodnichak, Cheryl, Weihrauch, Dorothee, Bonaldo, Paolo, Chilian, William M, Meszaros, J Gary

“…RATIONALE:We previously reported that type VI collagen deposition increases in the infarcted myocardium in vivo. To date, a specific role for this nonfibrillar…”
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Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation by Xia, Nan, Thodeti, Charles K., Hunt, Tom P., Xu, Qiaobing, Ho, Madelyn, Whitesides, George M., Westervelt, Robert, Ingber, Donald E.

“…Local physical interactions between cells and extracellular matrix (ECM) influence directional cell motility that is critical for tissue development, wound…”
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Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning by Sero, Julia E, Thodeti, Charles K, Mammoto, Akiko, Bakal, Chris, Thomas, Sheila, Ingber, Donald E

“…Physical interactions between cells and the extracellular matrix (ECM) guide directional migration by spatially controlling where cells form focal adhesions…”
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Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction by DelloStritto, Daniel J., Connell, Patrick J., Dick, Gregory M., Fancher, Ibra S., Klarich, Brittany, Fahmy, Joseph N., Kang, Patrick T., Chen, Yeong-Renn, Damron, Derek S., Thodeti, Charles K., Bratz, Ian N.

“…We demonstrated previously that TRPV1-dependent coupling of coronary blood flow (CBF) to metabolism is disrupted in diabetes. A critical amount of H 2 O 2…”
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A TRP to cardiac fibroblast differentiation by Thodeti, Charles K., Paruchuri, Sailaja, Meszaros, J. Gary

“…The differentiation of cardiac fibroblasts to myofibroblasts is one of the key events during cardiac remodeling, however, the molecular mechanism underlying…”
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