Search Results - "Thoden, J B"

Galactokinase: structure, function and role in type II galactosemia by Holden, H M, Thoden, J B, Timson, D J, Reece, R J

“…The conversion of beta- D-galactose to glucose 1-phosphate is accomplished by the action of four enzymes that constitute the Leloir pathway. Galactokinase…”
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Molecular Structure of Dihydroorotase:  A Paradigm for Catalysis through the Use of a Binuclear Metal Center by Thoden, James B, Phillips, George N, Neal, Tamiko M, Raushel, Frank M, Holden, Hazel M

“…Dihydroorotase plays a key role in pyrimidine biosynthesis by catalyzing the reversible interconversion of carbamoyl aspartate to dihydroorotate. Here we…”
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The Small Subunit of Carbamoyl Phosphate Synthetase:  Snapshots along the Reaction Pathway by Thoden, James B, Huang, Xinyi, Raushel, Frank M, Holden, Hazel M

“…Carbamoyl phosphate synthetase (CPS) plays a key role in both arginine and pyrimidine biosynthesis by catalyzing the production of carbamoyl phosphate. The…”
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Carbamoyl Phosphate Synthetase:  Caught in the Act of Glutamine Hydrolysis by Thoden, James B, Miran, Sophie G, Phillips, James C, Howard, Andrew J, Raushel, Frank M, Holden, Hazel M

“…Carbamoyl phosphate synthetase from Escherichia coli catalyzes the production of carbamoyl phosphate from two molecules of Mg2+ATP, one molecule of…”
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Carbamoyl phosphate synthetase: an amazing biochemical odyssey from substrate to product by Holden, H M, Thoden, J B, Raushel, F M

“…Carbamoyl phosphate synthetase (CPS) catalyzes one of the most remarkable reactions ever described in biological chemistry, in which carbamoyl phosphate is…”
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Three-Dimensional Structure of ATP:Corrinoid Adenosyltransferase from Salmonella typhimurium in Its Free State, Complexed with MgATP, or Complexed with Hydroxycobalamin and MgATP by Bauer, Cary B, Fonseca, Maris V, Holden, Hazel M, Thoden, James B, Thompson, Thomas B, Escalante-Semerena, Jorge C, Rayment, Ivan

“…In Salmonella typhimurium, formation of the cobalt−carbon bond in the biosynthetic pathway for adenosylcobalamin is catalyzed by the product of the cobA gene…”
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High‐resolution X‐ray structure of UDP‐galactose 4‐epimerase complexed with UDP‐phenol by Thoden, James B., Frey, Perry A., Holden, Hazel M.

“…UDP‐galactose 4‐epimerase from Escherichia coli catalyzes the interconversion of UDP‐glucose and UDP‐galactose. In recent years, the enzyme has been the…”
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Molecular Structure of Escherichia coli PurT-Encoded Glycinamide Ribonucleotide Transformylase by Thoden, James B, Firestine, Steven, Nixon, Andrew, Benkovic, Stephen J, Holden, Hazel M

“…In Escherichia coli, the PurT-encoded glycinamide ribonucleotide transformylase, or PurT transformylase, catalyzes an alternative formylation of glycinamide…”
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X-ray structures of the apo and MgATP-bound states of Dictyostelium discoideum myosin motor domain by Bauer, C B, Holden, H M, Thoden, J B, Smith, R, Rayment, I

“…Myosin is the most comprehensively studied molecular motor that converts energy from the hydrolysis of MgATP into directed movement. Its motile cycle consists…”
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Molecular Structure of Galactokinase by Thoden, James B., Holden, Hazel M.

“…Galactokinase plays a key role in normal galactose metabolism by catalyzing the ATP-dependent phosphorylation of α-d-galactose to galactose 1-phosphate. In…”
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Human UDP-galactose 4-epimerase. Accommodation of UDP-N-acetylglucosamine within the active site by Thoden, J B, Wohlers, T M, Fridovich-Keil, J L, Holden, H M

“…UDP-galactose 4-epimerase catalyzes the interconversion of UDP-galactose and UDP-glucose during normal galactose metabolism. One of the key structural features…”
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Crystallographic Evidence for Tyr 157 Functioning as the Active Site Base in Human UDP−Galactose 4-Epimerase by Thoden, James B, Wohlers, Travis M, Fridovich-Keil, Judith L, Holden, Hazel M

“…UDP-galactose 4-epimerase catalyzes the interconversion of UDP-glucose and UDP-galactose during normal galactose metabolism. In humans, deficiencies in this…”
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Three-Dimensional Structure of Escherichia coli Asparagine Synthetase B:  A Short Journey from Substrate to Product by Larsen, Todd M, Boehlein, Susan K, Schuster, Sheldon M, Richards, Nigel G. J, Thoden, James B, Holden, Hazel M, Rayment, Ivan

“…Asparagine synthetase B catalyzes the assembly of asparagine from aspartate, Mg2+ATP, and glutamine. Here, we describe the three-dimensional structure of the…”
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The Structure of 4-Hydroxybenzoyl-CoA Thioesterase from Arthrobacter sp. strain SU by Thoden, James B., Zhuang, Zhihao, Dunaway-Mariano, Debra, Holden, Hazel M.

“…The 4-chlorobenzoyl-CoA dehalogenation pathway in certain Arthrobacter and Pseudomonas bacterial species contains three enzymes: a ligase, a dehalogenase, and…”
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Rhodococcus l-Phenylalanine Dehydrogenase:  Kinetics, Mechanism, and Structural Basis for Catalytic Specifity by Brunhuber, Norbert M. W, Thoden, James B, Blanchard, John S, Vanhooke, Janeen L

“…Phenylalanine dehydrogenase catalyzes the reversible, pyridine nucleotide-dependent oxidative deamination of l-phenylalanine to form phenylpyruvate and…”
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Evolution of Enzymatic Activity in the Enolase Superfamily:  Functional Studies of the Promiscuous o-Succinylbenzoate Synthase from Amycolatopsis by Taylor Ringia, Erika A, Garrett, James B, Thoden, James B, Holden, Hazel M, Rayment, Ivan, Gerlt, John A

“…o-Succinylbenzoate synthase (OSBS) from Amycolatopsis, a member of the enolase superfamily, catalyzes the Mn2+-dependent exergonic dehydration of…”
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The Amidotransferase Family of Enzymes:  Molecular Machines for the Production and Delivery of Ammonia by Raushel, Frank M, Thoden, James B, Holden, Hazel M

“…The amidotransferase family of enzymes utilizes the ammonia derived from the hydrolysis of glutamine for a subsequent chemical reaction catalyzed by the same…”
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Mechanism of the Reaction Catalyzed by Isoaspartyl Dipeptidase from Escherichia coli by Martí-Arbona, Ricardo, Fresquet, Vicente, Thoden, James B, Davis, Melissa L, Holden, Hazel M, Raushel, Frank M

“…Isoaspartyl dipeptidase (IAD) is a member of the amidohydrolase superfamily and catalyzes the hydrolytic cleavage of β-aspartyl dipeptides. Structural studies…”
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The 1.5-angstrom resolution crystal structure of bacterial luciferase in low salt conditions by Fisher, A J, Thompson, T B, Thoden, J B, Baldwin, TO, Rayment, I

“…Bacterial luciferase is a flavin monooxygenase that catalyzes the oxidation of a long-chain aldehyde and releases energy in the form of visible light. A new…”
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Movement of the Biotin Carboxylase B-domain as a Result of ATP Binding by Thoden, James B., Blanchard, Carol Z., Holden, Hazel M., Waldrop, Grover L.

“…Acetyl-CoA carboxylase catalyzes the first committed step in fatty acid synthesis. In Escherichia coli, the enzyme is composed of three distinct protein…”
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