Search Results - "Thliveris, James A"

Doxorubicin-loaded iron oxide nanoparticles for glioblastoma therapy: a combinational approach for enhanced delivery of nanoparticles by Norouzi, Mohammad, Yathindranath, Vinith, Thliveris, James A., Kopec, Brian M., Siahaan, Teruna J., Miller, Donald W.

“…Although doxorubicin (DOX) is an effective anti-cancer drug with cytotoxicity in a variety of different tumors, its effectiveness in treating glioblastoma…”
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Neuregulin‐1 promotes remyelination and fosters a pro‐regenerative inflammatory response in focal demyelinating lesions of the spinal cord by Kataria, Hardeep, Alizadeh, Arsalan, Shahriary, Ghazaleh M., Saboktakin Rizi, Shekoofeh, Henrie, Ryan, Santhosh, Kallivalappil T., Thliveris, James A., Karimi‐Abdolrezaee, Soheila

“…Oligodendroglial cell death and demyelination are hallmarks of neurotrauma and multiple sclerosis that cause axonal damage and functional impairments…”
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Nitric oxide augments signaling for contraction in hypoxic pulmonary arterial smooth muscle-Implications for hypoxic pulmonary hypertension by Hinton, Martha, Thliveris, James A, Hatch, Grant M, Dakshinamurti, Shyamala

“…Hypoxic persistent pulmonary hypertension in the newborn (PPHN) is usually treated with oxygen and inhaled nitric oxide (NO), both pulmonary arterial…”
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Salinomycin-Loaded Iron Oxide Nanoparticles for Glioblastoma Therapy by Norouzi, Mohammad, Yathindranath, Vinith, Thliveris, James A, Miller, Donald W

“…Salinomycin is an antibiotic introduced recently as a new and effective anticancer drug. In this study, magnetic iron oxide nanoparticles (IONPs) were utilized…”
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Biodistribution of negatively charged iron oxide nanoparticles (IONPs) in mice and enhanced brain delivery using lysophosphatidic acid (LPA) by Sun, Zhizhi, Worden, Matthew, PhD, Thliveris, James A., PhD, Hombach-Klonisch, Sabine, PhD, Klonisch, Thomas, PhD, van Lierop, Johan, PhD, Hegmann, Torsten, PhD, Miller, Donald W., PhD

“…Abstract Effective treatment of brain disorders requires a focus on improving drug permeability across the blood–brain barrier (BBB). Herein, we examined the…”
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Efficacy of Flaxseed Compared to ACE Inhibition in Treating Anthracycline- and Trastuzumab-Induced Cardiotoxicity by Telles-Langdon, Sara M., Arya, Vibhuti, Haasbeek, Paris R., Cheung, David Y.C., Eekhoudt, Cameron R., Mackic, Lana, Bryson, Ashley N., Varghese, Sonu S., Austria, J. Alejandro, Thliveris, James A., Aukema, Harold M., Ravandi, Amir, Singal, Pawan K., Jassal, Davinder S.

“…Although the current combination of surgery, radiation, and chemotherapy is used in the breast-cancer setting, the administration of the anticancer drugs…”
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Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress by Rabinovich-Nikitin, Inna, Rasouli, Mina, Reitz, Cristine J., Posen, Illana, Margulets, Victoria, Dhingra, Rimpy, Khatua, Tarak N., Thliveris, James A., Martino, Tami A., Kirshenbaum, Lorrie A.

“…Cardiac function is highly reliant on mitochondrial oxidative metabolism and quality control. The circadian Clock gene is critically linked to vital…”
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Impact of Wnt/β‐catenin signaling on ethanol‐induced changes in brain endothelial cell permeability by Laksitorini, Marlyn D., Yathindranath, Vinith, Xiong, Wei, Parkinson, Fiona E., Thliveris, James A., Miller, Donald W.

“…Chronic exposure to ethanol is associated with enhanced leakiness in the brain microvessel endothelial cells that form the blood–brain barrier (BBB). As…”
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Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells by Nagakannan, Pandian, Iqbal, Mohamed Ariff, Yeung, Albert, Thliveris, James A., Rastegar, Mojgan, Ghavami, Saeid, Eftekharpour, Eftekhar

“…Oxidative damage and aggregation of cellular proteins is a hallmark of neuronal cell death after neurotrauma and chronic neurodegenerative conditions…”
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Caspase 3 activity in isolated fetal rat lung fibroblasts and rat periodontal ligament fibroblasts: cigarette smoke induced alterations by Ahmed, Asra, Thliveris, James A, Shaw, Anthony, Sowa, Michael, Gilchrist, James, Scott, James E

“…Cigarette smoking is the leading cause of preventable death and has been implicated in pathogenesis of pulmonary, oral and systemic diseases. Smoking during…”
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Acute upregulation of bone morphogenetic protein-4 regulates endogenous cell response and promotes cell death in spinal cord injury by Hart, Christopher G., Dyck, Scott M., Kataria, Hardeep, Alizadeh, Arsalan, Nagakannan, Pandian, Thliveris, James A., Eftekharpour, Eftekhar, Karimi-Abdolrezaee, Soheila

“…Traumatic spinal cord injury (SCI) elicits a cascade of secondary injury mechanisms that induce profound changes in glia and neurons resulting in their…”
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The FGF-2-triggered protection of cardiac subsarcolemmal mitochondria from calcium overload is mitochondrial connexin 43-dependent by Srisakuldee, Wattamon, Makazan, Zhanna, Nickel, Barbara E, Zhang, Feixiong, Thliveris, James A, Pasumarthi, Kishore B S, Kardami, Elissavet

“…Fibroblast growth factor 2 (FGF-2) protects the heart from ischaemia- and reperfusion-induced cell death by a mechanism linked to protein kinase C…”
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Simple, Hackable, Size-Selective, Amine-Functionalized Fe-Oxide Nanoparticles for Biomedical Applications by Manna, Palash Kumar, Nickel, Rachel, Wroczynskyj, Yaroslav, Yathindranath, Vinith, Li, Jie, Liu, Song, Thliveris, James A, Klonisch, Thomas, Miller, Donald W, van Lierop, Johan

“…A facile one-pot method for synthesizing amine-functionalized nonspherical Fe3O4 nanoparticles in gram-scale quantities is presented using just a single source…”
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One-Pot Synthesis of Iron Oxide Nanoparticles with Functional Silane Shells: A Versatile General Precursor for Conjugations and Biomedical Applications by Yathindranath, Vinith, Sun, Zhizhi, Worden, Matthew, Donald, Lynda J, Thliveris, James A, Miller, Donald W, Hegmann, Torsten

“…Iron oxide nanoparticles (IONPs) and their surface modifications with therapeutic or diagnostic (theranostic, TN) agents are of great interest. Here we present…”
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Modulation of intercellular junctions by cyclic-ADT peptides as a method to reversibly increase blood-brain barrier permeability by Laksitorini, Marlyn D, Kiptoo, Paul K, On, Ngoc H, Thliveris, James A, Miller, Donald W, Siahaan, Teruna J

“…It is challenging to deliver molecules to the brain for diagnosis and treatment of brain diseases. This is primarily because of the presence of the blood-brain…”
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Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models by Sun, Zhizhi, Yathindranath, Vinith, Worden, Matthew, Thliveris, James A, Chu, Stephanie, Parkinson, Fiona E, Hegmann, Torsten, Miller, Donald W

“…Aminosilane-coated iron oxide nanoparticles (AmS-IONPs) have been widely used in constructing complex and multifunctional drug delivery systems. However, the…”
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A comparison of biologically variable ventilation to recruitment manoeuvres in a porcine model of acute lung injury by Funk, Duane J, Graham, M Ruth, Girling, Linda G, Thliveris, James A, McManus, Bruce M, Walker, Elizabeth K Y, Rector, Edward S, Hillier, Craig, Scott, J Elliott, Mutch, W Alan C

“…Biologically variable ventilation (return of physiological variability in rate and tidal volume using a computer-controller) was compared to control mode…”
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Pelota Regulates Epidermal Differentiation by Modulating BMP and PI3K/AKT Signaling Pathways by Elkenani, Manar, Nyamsuren, Gunsmaa, Raju, Priyadharsini, Liakath-Ali, Kifayathullah, Hamdaoui, Aicha, Kata, Aleksandra, Dressel, Ralf, Klonisch, Thomas, Watt, Fiona M., Engel, Wolfgang, Thliveris, James A., Krishna Pantakani, D.V., Adham, Ibrahim M.

“…The depletion of evolutionarily conserved pelota protein causes impaired differentiation of embryonic and spermatogonial stem cells. In this study, we show…”
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Hyaluronidase 3 ( HYAL3) knockout mice do not display evidence of hyaluronan accumulation by Atmuri, Vasantha, Martin, Dianna C., Hemming, Richard, Gutsol, Alex, Byers, Sharon, Sahebjam, Solmaz, Thliveris, James A., Mort, John S., Carmona, Euridice, Anderson, Judy E., Dakshinamurti, Shyamala, Triggs-Raine, Barbara

“…Hyaluronidases are endoglycosidases that initiate the breakdown of hyaluronan (HA), an abundant component of the vertebrate extracellular matrix. In humans,…”
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A tea/vanadate decoction delivered orally over 14 months to diabetic rats induces long-term glycemic stability without organ toxicity by Clark, Tod A, Heyliger, Clayton E, Kopilas, Melanie, Edel, Andrea L, Junaid, Asad, Aguilar, Floribeth, Smyth, Donald D, Thliveris, James A, Merchant, Michele, Kim, Hae K, Pierce, Grant N

“…Abstract Vanadium can induce potent hypoglycemic effects in type 1 and type 2 diabetes mellitus animals, but toxic adverse effects have inhibited the…”
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