Search Results - "Thistlethwaite, F. C."

Social determinants of health inequalities in early phase clinical trials in Northern England by Rae, S., Shaya, S., Taylor, E., Hoben, J., Oluwashegun, D., Lowe, H., Haris, N., Bashir, S., Oing, C., Krebs, M. G., Thistlethwaite, F. C., Carter, L., Cook, N., Greystoke, A., Graham, D. M., Plummer, R.

“…Background Early phase clinical trials in Oncology represent a subspecialised area where UK patient selection is influenced by access to Experimental Cancer…”
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Engineering T cells for cancer therapy by MANSOOR, W, GILHAM, D. E, THISTLETHWAITE, F. C, HAWKINS, R. E

“…It is generally accepted that the immune system plays an important role in controlling tumour development. However, the interplay between tumour and immune…”
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Thymic lymphomas in mice with a truncating mutation in Brca2 by FRIEDMAN, L. S, THISTLETHWAITE, F. C, EVANS, M. J, PONDER, B. A. J, PATEL, K. J, YU, V. P. C. C, HYUNSOOK LEE, VENKITARAMAN, A. R, ABEL, K. J, CARLTON, M. B. L, HUNTER, S. M, COLLEDGE, W. H

“…Inherited mutations in the BRCA2 gene predispose women to breast and ovarian cancer. We created a mutation in the mouse Brca2 gene that terminates translation…”
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EPIC: an evaluation of the psychological impact of early-phase clinical trials in cancer patients by Jittla, P., Graham, D.M., Zhou, C., Halliwell, J., O’Reilly, S., Aruketty, S., Azizi, A., Germetaki, T., Lowe, J., Little, M., Punnett, G., McMahon, P., Benson, L., Carter, L., Krebs, M.G., Thistlethwaite, F.C., Darlington, E., Yorke, J., Cook, N.

“…Anxiety and depression in patients with cancer is associated with decreased quality of life and increased morbidity and mortality. However, these are often…”
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Involvement of Brca2 in DNA Repair by Patel, Ketan J, Yu, Veronica P.C.C, Lee, Hyunsook, Corcoran, Anne, Thistlethwaite, Fiona C, Evans, Martin J, Colledge, William H, Friedman, Lori S, Ponder, Bruce A.J, Venkitaraman, Ashok R

“…Abnormalities precipitated by a targeted truncation in the murine gene Brca2 define its involvement in DNA repair. In culture, cells harboring truncated Brca2…”
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Mitotic Checkpoint Inactivation Fosters Transformation in Cells Lacking the Breast Cancer Susceptibility Gene, Brca2 by Lee, Hyunsook, Trainer, Alison H, Friedman, Lori S, Thistlethwaite, Fiona C, Evans, Martin J, Ponder, Bruce A.J, Venkitaraman, Ashok R

“…The murine Brca2 gene encodes a nuclear protein implicated in DNA repair. Brca2 behaves as a tumor suppressor, but paradoxically, its truncation causes…”
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Weekly paclitaxel in the treatment of recurrent ovarian carcinoma by Byrd, L, Thistlethwaite, F C, Clamp, A, Ton, C, Hasan, J, Jayson, G C

“…To study the effect of weekly paclitaxel in the treatment of recurrent ovarian and peritoneal carcinoma. A retrospective analysis of patients treated at…”
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Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1–2 trial by de Bono, Johann S, Concin, Nicole, Hong, David S, Thistlethwaite, Fiona C, Machiels, Jean-Pascal, Arkenau, Hendrik-Tobias, Plummer, Ruth, Jones, Robert Hugh, Nielsen, Dorte, Windfeld, Kristian, Ghatta, Srinivas, Slomovitz, Brian M, Spicer, James F, Yachnin, Jeffrey, Ang, Joo Ern, Mau-Sørensen, Paul Morten, Forster, Martin David, Collins, Dearbhaile, Dean, Emma, Rangwala, Reshma A, Lassen, Ulrik

“…Tisotumab vedotin is a first-in-human antibody–drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is…”
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Adoptive transfer of T sub(reg) depleted autologous T cells in advanced renal cell carcinoma by Thistlethwaite, F C, Elkord, E, Griffiths, R W, Burt, D J, Shablak, A M, Campbell, JDM, Gilham, DE, Austin, E B, Stern, P L, Hawkins, R E

“…Purpose CD4 super(+)CD25 super(+) regulatory T (T sub(reg)) cells are present in increased numbers in patients with advanced cancer and CD25 super(+) T cell…”
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Killing of non‐Hodgkin lymphoma cells by autologous CD19 engineered T cells by Cheadle, Eleanor J., Gilham, David E., Thistlethwaite, Fiona C., Radford, John A., Hawkins, Robert E.

“…Summary Adoptive immunotherapy with tumour‐specific T cells is an emerging technology that may be applicable to a broad range of cancers. However, tumours can…”
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