Search Results - "Thirusangu, Prabhu"

Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer by Xiao, Yinan, Jin, Ling, Deng, Chaolin, Guan, Ye, Kalogera, Eleftheria, Ray, Upasana, Thirusangu, Prabhu, Staub, Julie, Sarkar Bhattacharya, Sayantani, Xu, Haotian, Fang, Xiaoling, Shridhar, Viji

“…The advanced or recurrent endometrial cancer (EC) has a poor prognosis because of chemoresistance. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3…”
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Quinacrine-Induced Autophagy in Ovarian Cancer Triggers Cathepsin-L Mediated Lysosomal/Mitochondrial Membrane Permeabilization and Cell Death by Thirusangu, Prabhu, Pathoulas, Christopher L, Ray, Upasana, Xiao, Yinan, Staub, Julie, Jin, Ling, Khurana, Ashwani, Shridhar, Viji

“…We previously reported that the antimalarial compound quinacrine (QC) induces autophagy in ovarian cancer cells. In the current study, we uncovered that QC…”
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Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma by Prashanth, T., Avin, B.R. Vijay, Thirusangu, Prabhu, Ranganatha, V. Lakshmi, Prabhakar, B.T., Sharath Chandra, J.N. Narendra, Khanum, Shaukath Ara

“…[Display omitted] •Novel coumarin analogs were synthesized with verity of substituents.•Docking studies have been done for the potent compound 13f.•In vitro…”
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PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive responses by Sarkar Bhattacharya, Sayantani, Thirusangu, Prabhu, Jin, Ling, Roy, Debarshi, Jung, Deokbeom, Xiao, Yinan, Staub, Julie, Roy, Bhaskar, Molina, Julian R., Shridhar, Viji

“…The metabolic signatures of cancer cells are often associated with elevated glycolysis. Pharmacological (PFK158 treatment) and genetic inhibition of…”
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Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization by Ray, Upasana, Roy, Debarshi, Jin, Ling, Thirusangu, Prabhu, Staub, Julie, Xiao, Yinan, Kalogera, Eleftheria, Wahner Hendrickson, Andrea E, Cullen, Grace D, Goergen, Krista, Oberg, Ann L, Shridhar, Viji

“…Abstract Background Aberrant lipogenicity and deregulated autophagy are common in most advanced human cancer and therapeutic strategies to exploit these…”
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Anti-neoplastic pharmacophore benzophenone-1 coumarin (BP-1C) targets JAK2 to induce apoptosis in lung cancer by Sherapura, Ankith, Malojirao, Vikas H., Thirusangu, Prabhu, Sharath, B. S., Kandagalla, Shivananda, Vigneshwaran, V., Novak, Jurica, Ranganatha, Lakshmi, Ramachandra, Y. L., Baliga, Shrinath M., Khanum, Shaukath Ara, Prabhakar, B. T.

“…Reigning of the abnormal gene activation associated with survival signalling in lung cancer leads to the anomalous growth and therapeutic failure. Targeting…”
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Quinacrine Induces Nucleolar Stress in Treatment-Refractory Ovarian Cancer Cell Lines by Oien, Derek B., Ray, Upasana, Pathoulas, Christopher L., Jin, Ling, Thirusangu, Prabhu, Jung, Deokbeom, Kumka, Joseph E., Xiao, Yinan, Sarkar Bhattacharya, Sayantani, Montoya, Dennis, Chien, Jeremy, Shridhar, Viji

“…A considerable subset of gynecologic cancer patients experience disease recurrence or acquired resistance, which contributes to high mortality rates in ovarian…”
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Synthesis, molecular docking, and apoptogenic efficacy of novel N-heterocycle analogs to target B-cell lymphoma 2/X-linked inhibitors of apoptosis proteins to regress melanoma by Zabiulla, Zabiulla, Malojirao, Vikas H., Mohammed, Yasser Hussein Eissa, Thirusangu, Prabhu, Prabhakar, B. T., Khanum, Shaukath Ara

“…The novel series of piperidine conjugated benzophenone analogs with amide link 11a – l were synthesized in a multistep process. The structures of these…”
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Correction to: Synthesis, molecular docking, and apoptogenic efficacy of novel N-heterocycle analogs to target B-cell lymphoma 2/X-linked inhibitors of apoptosis proteins to regress melanoma by Zabiulla, Malojirao, Vikas H., Mohammed, Yasser Hussein Eissa, Thirusangu, Prabhu, Prabhakar, B. T., Khanum, Shaukath Ara

“…The original version of this article unfortunately contained an error in author group. The first author name was repeated twice…”
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One more step toward treatment of PARP inhibitor-resistant ovarian cancers by Ray, Upasana, Thirusangu, Prabhu, Shridhar, Viji

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Repurposing quinacrine for treatment-refractory cancer by Oien, Derek B., Pathoulas, Christopher L., Ray, Upasana, Thirusangu, Prabhu, Kalogera, Eleftheria, Shridhar, Viji

“…Quinacrine, also known as mepacrine, has originally been used as an antimalarial drug for close to a century, but was recently rediscovered as an anticancer…”
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Exploiting LRRC15 as a Novel Therapeutic Target in Cancer by Ray, Upasana, Pathoulas, Christopher L, Thirusangu, Prabhu, Purcell, James W, Kannan, Nagarajan, Shridhar, Viji

“…Abundant fibrotic stroma is a typical feature of most solid tumors, and stromal activation promotes oncogenesis, therapy resistance, and metastatic…”
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PFKFB3 works on the FAK-STAT3-SOX2 axis to regulate the stemness in MPM by Sarkar Bhattacharya, Sayantani, Thirusangu, Prabhu, Jin, Ling, Staub, Julie, Shridhar, Viji, Molina, Julian R.

“…Background Malignant pleural mesothelioma (MPM) is an aggressive neoplasm and often acquires chemoresistance by increasing stemness in tumour tissue, thereby…”
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PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma by Thirusangu, Prabhu, Ray, Upasana, Sarkar Bhattacharya, Sayantani, Oien, Derek B., Jin, Ling, Staub, Julie, Kannan, Nagarajan, Molina, Julian R., Shridhar, Viji

“…PFKFB3 (6-phosphofructo-2-kinase) is the rate-limiting enzyme of glycolysis and is overexpressed in several human cancers that are associated with poor…”
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Abstract 1936: Autophagy-dependent therapeutic targeting of group III phospholipase A2 attenuates ovarian cancer metastasis by Ray, Upasana, Roy, Debarshi, Jin, Ling, Thirusangu, Prabhu, Staub, Julie, Xiao, Yinan, Shridhar, Viji

“…Abstract Objective: Aberrant lipogenicity and deregulated autophagy are common in most advanced human cancer and therapeutic strategies to exploit these…”
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Abstract 1937: Quinacrine-induced autophagy in ovarian cancer triggers cathepsin-L mediated lysosomal/mitochondrial membrane permeabilization and cell death by Thirusangu, Prabhu, Pathoulas, Christopher L., Ray, Upasana, xiao, Yinan, Staub, Julie, Khurana, Ashwani, Shridhar, Vijayalakshmi

“…Abstract Background: Lysosomes are acidic organelles that contain numerous cathepsins and acid hydrolases. Lysosomal membrane permeabilization (LMP) and the…”
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Correction to: PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma by Thirusangu, Prabhu, Ray, Upasana, Sarkar Bhattacharya, Sayantani, Oien, Derek B., Jin, Ling, Staub, Julie, Kannan, Nagarajan, Molina, Julian R., Shridhar, Viji

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Abstract 1046: Synergistic cytotoxic effect of sulfated glycolipid PG545 in combination with ATR inhibition in ovarian cancer cells by Xiao, Yinan, Deng, Chaolin, Guan, Ye, Jin, Ling, Ray, Upasana, Thirusangu, Prabhu, Staub, Julie, Xu, Haotian, Shridhar, Viji

“…Abstract Despite the advances in the molecular understanding of ovarian cancer (OC), improvements in therapy are still needed. PG545 is a highly sulfated small…”
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Targeting LRRC15 Inhibits Metastatic Dissemination of Ovarian Cancer by Ray, Upasana, Jung, Deok-Beom, Jin, Ling, Xiao, Yinan, Dasari, Subramanyam, Sarkar Bhattacharya, Sayantani, Thirusangu, Prabhu, Staub, Julie K, Roy, Debarshi, Roy, Bhaskar, Weroha, S John, Hou, Xiaonan, Purcell, James W, Bakkum-Gamez, Jamie N, Kaufmann, Scott H, Kannan, Nagarajan, Mitra, Anirban K, Shridhar, Viji

“…Dissemination of ovarian cancer cells can lead to inoperable metastatic lesions in the bowel and omentum that cause patient death. Here we show that LRRC15, a…”
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PG545 sensitizes ovarian cancer cells to PARP inhibitors through modulation of RAD51-DEK interaction by Ray, Upasana, Thirusangu, Prabhu, Jin, Ling, Xiao, Yinan, Pathoulas, Christopher L., Staub, Julie, Erskine, Courtney L., Dredge, Keith, Hammond, Edward, Block, Matthew S., Kaufmann, Scott H., Bakkum-Gamez, Jamie N., Shridhar, Viji

“…PG545 (Pixatimod) is a highly sulfated small molecule known for its ability to inhibit heparanase and disrupt signaling mediated by heparan-binding-growth…”
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