Search Results - "Thirup, S."

Receptor-mediated exopolysaccharide perception controls bacterial infection by Kawaharada, Y., Kelly, S., Nielsen, M. Wibroe, Hjuler, C. T., Gysel, K., Muszyński, A., Carlson, R. W., Thygesen, M. B., Sandal, N., Asmussen, M. H., Vinther, M., Andersen, S. U., Krusell, L., Thirup, S., Jensen, K. J., Ronson, C. W., Blaise, M., Radutoiu, S., Stougaard, J.

“…Surface polysaccharides are important for bacterial interactions with multicellular organisms, and some are virulence factors in pathogens. In the…”
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Ligands bind to Sortilin in the tunnel of a ten-bladed β-propeller domain by Petersen, Claus M, Thirup, Søren S, Quistgaard, Esben M, Madsen, Peder, Grøftehauge, Morten K, Nissen, Poul

“…The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2-Å resolution, revealing that the C-terminal part of neurotensin…”
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E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form by Johansen, Jesper S, Kavaliauskas, Darius, Pfeil, Shawn H, Blaise, Mickaël, Cooperman, Barry S, Goldman, Yale E, Thirup, Søren S, Knudsen, Charlotte R

“…Abstract According to the traditional view, GTPases act as molecular switches, which cycle between distinct 'on' and 'off' conformations bound to GTP and GDP,…”
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Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu by Thirup, Søren S., Van, Lan Bich, Nielsen, Tine K., Knudsen, Charlotte R.

“…Translation elongation factor EF-Tu belongs to the superfamily of guanine-nucleotide binding proteins, which play key cellular roles as regulatory switches…”
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Revisiting the structure of the Vps10 domain of human sortilin and its interaction with neurotensin by Quistgaard, Esben M., Grøftehauge, Morten K., Madsen, Peder, Pallesen, Lone T., Christensen, Brian, Sørensen, Esben S., Nissen, Poul, Petersen, Claus M., Thirup, Søren S.

“…Sortilin is a multifunctional receptor involved in sorting and apoptosis. We have previously reported a 2.0‐Å structure of the Vps10 ectodomain in complex with…”
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Sequence and structural analysis of the Asp-box motif and Asp-box beta-propellers; a widespread propeller-type characteristic of the Vps10 domain family and several glycoside hydrolase families by Quistgaard, Esben M, Thirup, Søren S

“…The Asp-box is a short sequence and structure motif that folds as a well-defined beta-hairpin. It is present in different folds, but occurs most prominently as…”
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GGA Autoinhibition Revisited by Cramer, Jacob F, Gustafsen, Camilla, Behrens, Manja A, Oliveira, Cristiano L.P, Pedersen, Jan Skov, Madsen, Peder, Petersen, Claus Munck, Thirup, Søren S

“…The cytosolic adaptors GGA1-3 mediate sorting of transmembrane proteins displaying a C-terminal acidic dileucine motif (DXXLL) in their cytosolic domain. GGA1…”
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Using known substructures in protein model building and crystallography by Jones, T.A., Thirup, S.

“…Retinol binding protein can be constructed from a small number of large substructures taken from three unrelated proteins. The known structures are treated as…”
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The ternary complex of aminoacylated tRNA and EF-Tu-GTP. Recognition of a bond and a fold by Nissen, P., Kjeldgaard, M., Thirup, S., Clark, B.F.C., Nyborg, J.

“…The refined crystal structure of the ternary complex of yeast Phe-tRNA Phe, Thermus aquaticus elongation factor EF-Tu and the non-hydrolyzable GTP analog,…”
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Legume receptors perceive the rhizobial lipochitin oligosaccharide signal molecules by direct binding by Broghammer, Angelique, Krusell, Lene, Blaise, Mickaël, Sauer, Jørgen, Sullivan, John T, Maolanon, Nicolai, Vinther, Maria, Lorentzen, Andrea, Madsen, Esben B, Jensen, Knud J, Roepstorff, Peter, Thirup, Søren, Ronson, Clive W, Thygesen, Mikkel B, Stougaard, Jens

“…Lipochitin oligosaccharides called Nod factors function as primary rhizobial signal molecules triggering legumes to develop new plant organs: root nodules that…”
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Isolation, crystallisation, and preliminary X-ray analysis of the bovine mitochondrial EF-Tu:GDP and EF-Tu:EF-Ts complexes by Karring, Henrik, Andersen, Gregers R, Thirup, Søren S, Nyborg, Jens, Spremulli, Linda L, Clark, Brian F.C

“…Previous studies have shown that when bovine mitochondrial elongation factor Ts (EF-Ts) is expressed in Escherichia coli, it forms a tightly associated complex…”
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Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X‐ray crystallography by Cour, T.F., Nyborg, J., Thirup, S., Clark, B.F.

“…Structural details of the guanosine diphosphate binding to a modified form of elongation factor Tu from Escherichia coli, resulting from X‐ray crystallographic…”
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Crystallization and preliminary X-ray diffraction studies of psoriasin by Nolsøe, S., Thirup, S., Etzerodt, M., Thøgersen, H. C., Nyborg, J.

“…Crystals of psoriasin, a protein related to the skin disease psoriasis, have been grown in two different crystal forms. Form I represents the protein in the…”
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Crystal Structure of the Ternary Complex of Phe-tRNA$^{Phe}$, EF-Tu, and a GTP Analog by Nissen, Poul, Kjeldgaard, Morten, Thirup, Søren, Polekhina, Galina, Reshetnikova, Ludmila, Brian F. C. Clark, Nyborg, Jens

“…The structure of the ternary complex consisting of yeast phenylalanyl-transfer RNA (Phe-tRNA$^{Phe}$), Thermus aquaticus elongation factor Tu (EF-Tu), and the…”
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The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation by Kjeldgaard, M, Nissen, P, Thirup, S, Nyborg, J

“…Elongation factor Tu (EF-Tu) is a GTP-binding protein that is crucial for protein biosynthesis. In the GTP form of the molecule, EF-Tu binds tightly to…”
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Helix unwinding in the effector region of elongation factor EF-Tu–GDP by Polekhina, Galina, Thirup, Søren, Kjeldgaard, Morten, Nissen, Poul, Lippmann, Corinna, Nyborg, Jens

“…Background Elongation factor Tu (EF-Tu) in its GTP conformation is a carrier of aminoacylated tRNAs (aa-tRNAs) to the ribosomal A site during protein…”
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Up, down, and around: identifying recurrent interactions within and between super-secondary structures in β-propellers by Thirup, Søren, Gupta, Vikas, Quistgaard, Esben M

“…The examination and analysis of super-secondary structures or other specific structural patterns associated with particular functions, sequence motifs, or…”
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High resolution crystal structure of bovine mitochondrial EF-tu in complex with GDP by Andersen, Gregers R, Thirup, Søren, Spremulli, Linda L, Nyborg, Jens

“…The crystal structure of bovine mitochondrial elongation factor Tu (EF-Tu) in complex with GDP has been determined at a resolution of 1.94 Å. The structure is…”
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The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin by Schrøder, Tenna Juul, Christensen, Søren, Lindberg, Samsa, Langgård, Morten, David, Laurent, Maltas, Philip J, Eskildsen, Jørgen, Jacobsen, Jan, Tagmose, Lena, Simonsen, Klaus Bæk, Biilmann Rønn, Lars Christian, de Jong, Inge E M, Malik, Ibrahim J, Karlsson, Jens-Jakob, Bundgaard, Christoffer, Egebjerg, Jan, Stavenhagen, Jeffrey B, Strandbygård, Dorthe, Thirup, Søren, Andersen, Jacob Lauwring, Uppalanchi, Srinivas, Pervaram, Sridhar, Kasturi, Shiva Prasad, Eradi, Pradheep, Sakumudi, Durga Rao, Watson, Stephen P

“…The identification of the novel, selective, orally bioavailable Sortilin inhibitor AF38469 is described. Structure-activity relationships and syntheses are…”
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Structure of the ternary complex of EF-Tu: macromolecular mimicry in translation by Nyborg, Jens, Nissen, Poul, Kjeldgaard, Morten, Thirup, Søren, Polekhina, Galina, Clark, Brian F.C., Reshetnikova, Ludmila

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