Search Results - "Thirup, Søren S"

Ligands bind to Sortilin in the tunnel of a ten-bladed β-propeller domain by Petersen, Claus M, Thirup, Søren S, Quistgaard, Esben M, Madsen, Peder, Grøftehauge, Morten K, Nissen, Poul

“…The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2-Å resolution, revealing that the C-terminal part of neurotensin…”
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E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form by Johansen, Jesper S, Kavaliauskas, Darius, Pfeil, Shawn H, Blaise, Mickaël, Cooperman, Barry S, Goldman, Yale E, Thirup, Søren S, Knudsen, Charlotte R

“…Abstract According to the traditional view, GTPases act as molecular switches, which cycle between distinct 'on' and 'off' conformations bound to GTP and GDP,…”
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Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu by Thirup, Søren S., Van, Lan Bich, Nielsen, Tine K., Knudsen, Charlotte R.

“…Translation elongation factor EF-Tu belongs to the superfamily of guanine-nucleotide binding proteins, which play key cellular roles as regulatory switches…”
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Revisiting the structure of the Vps10 domain of human sortilin and its interaction with neurotensin by Quistgaard, Esben M., Grøftehauge, Morten K., Madsen, Peder, Pallesen, Lone T., Christensen, Brian, Sørensen, Esben S., Nissen, Poul, Petersen, Claus M., Thirup, Søren S.

“…Sortilin is a multifunctional receptor involved in sorting and apoptosis. We have previously reported a 2.0‐Å structure of the Vps10 ectodomain in complex with…”
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Sequence and structural analysis of the Asp-box motif and Asp-box beta-propellers; a widespread propeller-type characteristic of the Vps10 domain family and several glycoside hydrolase families by Quistgaard, Esben M, Thirup, Søren S

“…The Asp-box is a short sequence and structure motif that folds as a well-defined beta-hairpin. It is present in different folds, but occurs most prominently as…”
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GGA Autoinhibition Revisited by Cramer, Jacob F, Gustafsen, Camilla, Behrens, Manja A, Oliveira, Cristiano L.P, Pedersen, Jan Skov, Madsen, Peder, Petersen, Claus Munck, Thirup, Søren S

“…The cytosolic adaptors GGA1-3 mediate sorting of transmembrane proteins displaying a C-terminal acidic dileucine motif (DXXLL) in their cytosolic domain. GGA1…”
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Isolation, crystallisation, and preliminary X-ray analysis of the bovine mitochondrial EF-Tu:GDP and EF-Tu:EF-Ts complexes by Karring, Henrik, Andersen, Gregers R, Thirup, Søren S, Nyborg, Jens, Spremulli, Linda L, Clark, Brian F.C

“…Previous studies have shown that when bovine mitochondrial elongation factor Ts (EF-Ts) is expressed in Escherichia coli, it forms a tightly associated complex…”
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Ligands bind to Sortilin in the tunnel of a ten-bladed [beta]-propeller domain by Quistgaard, Esben M, Madsen, Peder, Grøftehauge, Morten K, Nissen, Poul, Petersen, Claus M, Thirup, Søren S

“…The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2 angstroms resolution, revealing that the C-terminal part of…”
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