Search Results - "Thirumurugan, Kavitha"

Autophagy: a molecular switch to regulate adipogenesis and lipolysis by Sekar, Mouliganesh, Thirumurugan, Kavitha

“…Obesity is a complex epidemic disease caused by an imbalance of adipose tissue function that results in hyperglycemia, hyperlipidemia and insulin resistance…”
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Longevity-promoting efficacies of rutin in high fat diet fed Drosophila melanogaster by Chattopadhyay, Debarati, Thirumurugan, Kavitha

“…Composition of diet significantly impacts lifespan in Drosophila melanogaster . Diet-composition becomes even more crucial while assessing a phytocompound for…”
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Longevity promoting efficacies of different plant extracts in lower model organisms by Chattopadhyay, Debarati, Thirumurugan, Kavitha

“…•Potential of plant extracts to impart longevity in lower model organisms.•Major mechanisms operating: insulin like growth factor (IGF) signaling pathway,…”
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Modulatory functions of bioactive fruits, vegetables and spices in adipogenesis and angiogenesis by Sarkar, Priyanka, Thirumurugan, Kavitha

“…[Display omitted] •Adipostatic potential of fruits, vegetables and spices.•Angiostatic potential of fruits, vegetables and spices.•Involvement of COX2 and NO…”
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Flavanone naringenin: An effective antihyperglycemic and antihyperlipidemic nutraceutical agent on high fat diet fed streptozotocin induced type 2 diabetic rats by Priscilla, David Hansi, Jayakumar, Murugesan, Thirumurugan, Kavitha

“…•Generated an ideal type 2 diabetic model.•Naringenin treatment reduced hyperglycemia, hyperlipidemia and enhanced antioxidant activity in diabetic…”
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Load-dependent mechanism of nonmuscle myosin 2 by Kovács, Mihály, Thirumurugan, Kavitha, Knight, Peter J, Sellers, James R

“…Loads on molecular motors regulate and coordinate their function. In a study that directly measures properties of internally strained myosin 2 heads bound to…”
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Cinnamon extract inhibits α-glucosidase activity and dampens postprandial glucose excursion in diabetic rats by Mohamed Sham Shihabudeen, H, Hansi Priscilla, D, Thirumurugan, Kavitha

“…α-glucosidase inhibitors regulate postprandial hyperglycemia (PPHG) by impeding the rate of carbohydrate digestion in the small intestine and thereby hampering…”
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In Silico Analysis to Link Insulin Resistance, Obesity and Ageing with Alzheimer’s Disease by Sarkar, Priyanka, Jayaraj, Premkumar, Patwardhan, Ketaki, Yeole, Samiksha, Das, Sourajit, Somaiya, Yash, Desikan, Rajagopal, Thirumurugan, Kavitha

“…The process of ageing accompanies several metabolic diseases. With ageing, fats accumulate to increase the visceral and abdominal adiposity leading to…”
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Evidence that Chemical Chaperone 4-Phenylbutyric Acid Binds to Human Serum Albumin at Fatty Acid Binding Sites by Roy, Debasish, Kumar, Vinod, James, Joel, Shihabudeen, Mohamed Sham, Kulshrestha, Shweta, Goel, Varun, Thirumurugan, Kavitha

“…Endoplasmic reticulum stress elicits unfolded protein response to counteract the accumulating unfolded protein load inside a cell. The chemical chaperone,…”
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The cargo-binding domain regulates structure and activity of myosin 5 by Knight, Peter J, Thirumurugan, Kavitha, Sakamoto, Takeshi, Hammer, John A, Sellers, James R

“…Myosin 5 is a two-headed motor protein that moves cargoes along actin filaments. Its tail ends in paired globular tail domains (GTDs) thought to bind cargo. At…”
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The Predicted Coiled-coil Domain of Myosin 10 Forms a Novel Elongated Domain That Lengthens the Head by Knight, Peter J., Thirumurugan, Kavitha, Xu, Yuhui, Wang, Fei, Kalverda, Arnout P., Stafford, Walter F., Sellers, James R., Peckham, Michelle

“…Myosin 10 contains a region of predicted coiled coil 120 residues long. However, the highly charged nature and pattern of charges in the proximal 36 residues…”
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Role of the Tail in the Regulated State of Myosin 2 by Jung, Hyun Suk, Billington, Neil, Thirumurugan, Kavitha, Salzameda, Bridget, Cremo, Christine R., Chalovich, Joseph M., Chantler, Peter D., Knight, Peter J.

“…Myosin 2 from vertebrate smooth muscle or non-muscle sources is in equilibrium between compact, inactive monomers and thick filaments under physiological…”
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R1 Motif Is the Major Actin-Binding Domain of TRIOBP‑4 by Bao, Jianjun, Bielski, Elizabeth, Bachhawat, Ankita, Taha, Doaa, Gunther, Laura K, Thirumurugan, Kavitha, Kitajiri, Shin-ichiro, Sakamoto, Takeshi

“…TRIOBP is an actin-bundling protein. Mutations of TRIOBP are associated with human deafness DFNB28. In vitro, TRIOBP isoform 4 (TRIOBP-4) forms dense F-actin…”
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Regulated Conformation of Myosin V by Wang, Fei, Thirumurugan, Kavitha, Stafford, Walter F., Hammer, John A., Knight, Peter J., Sellers, James R.

“…We have found that myosin V, an important actin-based vesicle transporter, has a folded conformation that is coupled to inhibition of its enzymatic activity in…”
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New insights into TNFα/PTP1B and PPARγ pathway through RNF213- a link between inflammation, obesity, insulin resistance, and Moyamoya disease by Sarkar, Priyanka, Thirumurugan, Kavitha

“…[Display omitted] •Construction of interactome for RNF213.•Understand the involvement of RNF213 interactome in adipogenesis.•Role of RNF213 in TNFα-mediated…”
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Understanding cellular senescence: pathways involved, therapeutics and longevity aiding by Kumar, Ashish, Thirumurugan, Kavitha

“…A normal somatic cell undergoes cycles of finite cellular divisions. The presence of surveillance checkpoints arrests cell division in response to stress…”
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Autophagic Regulation of Adipogenesis Through TP53INP2: Insights from In Silico and In Vitro Analysis by Sekar, Mouliganesh, Thirumurugan, Kavitha

“…Obesity is an epidemic disease associated with multimorbidity resulting in higher mortality risk. The imbalance between energy storage and expenditure is the…”
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Dichotomous Effect of Caffeine, Curcumin, and Naringenin on Genomic DNA of Normal and Diabetic Subjects by Thirumurugan, Kavitha, Raghunathan, Divya, Somaiah, Ashok, Chattopadhyay, Debarati

“…Nutraceutical compounds show antioxidant and prooxidant properties under stress conditions like cancer, diabetes, and other diseases. The objective of this…”
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Use of negative stain and single-particle image processing to explore dynamic properties of flexible macromolecules by Burgess, Stan A., Walker, Matt L., Thirumurugan, Kavitha, Trinick, John, Knight, Peter J.

“…Flexible macromolecules pose special difficulties for structure determination by crystallography or NMR. Progress can be made by electron microscopy, but…”
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In silico explanation for the causalities of deleterious RNF213 SNPs in Moyamoya disease and insulin resistance by Sarkar, Priyanka, Thirumurugan, Kavitha

“…[Display omitted] •In silico analysis of the basic characteristics of RNF213 as a protein.•A detailed analysis of clinically reported and predicted SNPs of…”
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