Search Results - "Thirumal Kumar, D."

Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach by P, Sneha, D, Thirumal Kumar, C, George Priya Doss, R, Siva, Zayed, Hatem

“…Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. Over the past years, several…”
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Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach by Udhaya Kumar, S, Thirumal Kumar, D, Bithia, R, Sankar, Srivarshini, Magesh, R, Sidenna, Mariem, George Priya Doss, C, Zayed, Hatem

“…Familial hypercholesterolemia (FH) is one of the major risk factor for the progression of atherosclerosis and coronary artery disease. This study focused on…”
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Evaluation of Supervised Machine Learning Algorithms and Computational Structural Validation of Single Nucleotide Polymorphisms Related to Acute Liver Injury with Paracetamol by Sridharan, Kannan, Balasundaram, Ambritha, Kumar, D Thirumal, Doss, C George Priya

“…To identify single nucleotide polymorphisms (SNPs) of paracetamol-metabolizing enzymes that can predict acute liver injury. Paracetamol is a commonly…”
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Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type‐2 by P, Sneha, Ebrahimi, Elaheh Ahmad, Ghazala, Sara Ahmed, D, Thirumal Kumar, R, Siva, Priya Doss C, George, Zayed, Hatem

“…Galactosemia type 2 is an autosomal recessive disorder characterized by the deficiency of galactokinase (GALK) enzyme due to missense mutations in GALK1 gene,…”
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Determination of potential combination of non‐β‐lactam, β‐lactam, and β‐lactamase inhibitors/β‐lactam enhancer against class D oxacillinases producing Acinetobacter baumannii: Evidence from in‐vitro, molecular docking and dynamics simulation by Gopikrishnan, Mohanraj, Ramireddy, Sriroopreddy, Varghese, Rinku Polachirakkal, Bakathavatchalam, Yamuna Devi, D, Thirumal Kumar, Manesh, Abi, Walia, Kamini, Veeraraghavan, Balaji, C, George Priya Doss

“…Carbapenem‐resistant Acinetobacter baumannii, a predominant nosocomial pathogen in hospitals of intensive care units, is associated with bacteremia and…”
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Mixed azo dyes degradation by an intracellular azoreductase enzyme from alkaliphilic Bacillus subtilis: a molecular docking study by Krithika, A., Gayathri, K. Veena, Kumar, D. Thirumal, Doss, C. George Priya

“…The rise of pollution due to the dye industries and textile wastes are evolving rapidly every day. The dyes are used in different trade names by the textile…”
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Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach by S, Udhaya Kumar, Sankar, Srivarshini, Younes, Salma, D, Thirumal Kumar, Ahmad, Muneera Naseer, Okashah, Sarah Samer, Kamaraj, Balu, Al-Subaie, Abeer Mohammed, C, George Priya Doss, Zayed, Hatem

“…Filamins (FLN) are a family of actin-binding proteins involved in regulating the cytoskeleton and signaling phenomenon by developing a network with F-actin and…”
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Computational modelling approaches as a potential platform to understand the molecular genetics association between Parkinson’s and Gaucher diseases by Thirumal Kumar, D., Eldous, Hend Ghasan, Mahgoub, Zainab Alaa, George Priya Doss, C., Zayed, Hatem

“…Gaucher’s disease (GD) is a genetic disorder in which glucocerebroside accumulates in cells and specific organs. It is broadly classified into type I, type II…”
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A Molecular Docking and Dynamics Approach to Screen Potent Inhibitors Against Fosfomycin Resistant Enzyme in Clinical Klebsiella pneumoniae by Thirumal Kumar, D., Lavanya, P., George Priya Doss, C., Tayubi, Iftikhar Aslam, Naveen Kumar, D. R, Francis Yesurajan, I., Siva, R., Balaji, V.

“…ABSTRACT Klebsiella pneumoniae, BA6753 was cultured from a patient in the Clinical Microbiology Laboratory of Christian Medical College. K. pneumoniae, BA6753…”
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Integrative Bioinformatics Approaches to Map Potential Novel Genes and Pathways Involved in Ovarian Cancer by Kumar, S Udhaya, Kumar, D Thirumal, Siva, R, Doss, C George Priya, Zayed, Hatem

“…Ovarian cancer (OC) is the seventh most commonly detected cancer among women. This study aimed to map the hub and core genes and potential pathways that might…”
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Unravelling the Relacatib activity against the CTSK proteins causing pycnodysostosis: a molecular docking and dynamics approach by Kannan, Priyanka, A., Hadeefa Begum, N., Madhana Priya, D., Thirumal Kumar, Ramanathan, Gnansambandan, Eswaramoorthy, Rajalakshmanan, Ramasamy, Magesh

“…Pycnodysostosis is an atypical autosomal recessive condition of Lysosomal storage disorder that originated due to the deficit of the enzyme Cathepsin K which…”
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Structural Analysis of G1691S Variant in the Human Filamin B Gene Responsible for Larsen Syndrome: A Comparative Computational Approach by P, Sneha, D, Kumar Thirumal, Tanwar, Himani, R, Siva, C, George Priya Doss, Zayed, Hatem

“…ABSTRACT Larsen syndrome (LRS) is a rare genetic disease associated with variable manifestations including skeletal malformations, dislocations of the large…”
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Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2 by Thirumal Kumar, D., Jerushah Emerald, L., George Priya Doss, C., Sneha, P., Siva, R., Charles Emmanuel Jebaraj, W., Zayed, Hatem

“…The 2-hydroxyglutaric aciduria (2-HGA) is a rare neurometabolic disorder that leads to the development of brain damage. It is classified into three categories:…”
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Dysregulation of Signaling Pathways Due to Differentially Expressed Genes From the B-Cell Transcriptomes of Systemic Lupus Erythematosus Patients - A Bioinformatics Approach by Udhaya Kumar, S, Thirumal Kumar, D, Siva, R, George Priya Doss, C, Younes, Salma, Younes, Nadin, Sidenna, Mariem, Zayed, Hatem

“…Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder that is clinically complex and has increased production of autoantibodies. Via…”
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The Rise and Impact of COVID-19 in India by Kumar, S. Udhaya, Kumar, D. Thirumal, Christopher, B. Prabhu, Doss, C. George Priya

“…The coronavirus disease (COVID-19) pandemic, which originated in the city of Wuhan, China, has quickly spread to various countries, with many cases having been…”
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Involvement of Essential Signaling Cascades and Analysis of Gene Networks in Diabesity by S., Udhaya Kumar, Rajan, Bithia, D., Thirumal Kumar, V., Anu Preethi, Abunada, Taghreed, Younes, Salma, Okashah, Sarah, Ethiraj, Selvarajan, C., George Priya Doss, Zayed, Hatem

“…(1) Aims: Diabesity, defined as diabetes occurring in the context of obesity, is a serious health problem that is associated with an increased risk of…”
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A computational method to characterize the missense mutations in the catalytic domain of GAA protein causing Pompe disease by Thirumal Kumar, D, Umer Niazullah, Maryam, Tasneem, Sadia, Judith, E, Susmita, B, George Priya Doss, C, Selvarajan, E, Zayed, Hatem

“…Pompe disease is an autosomal recessive lysosomal storage disease caused by acid α‐glucosidase (GAA) deficiency, resulting in intralysosomal accumulation of…”
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A comparative computational approach toward pharmacological chaperones (NN-DNJ and ambroxol) on N370S and L444P mutations causing Gaucher's disease by Thirumal Kumar, D, Iyer, Sharada, Christy, J Priyadharshini, Siva, R, Tayubi, Iftikhar Aslam, George Priya Doss, C, Zayed, Hatem

“…Gaucher's disease (GD) is the most commonly known lysosomal disorder that occurs due to mutations in the β-glucocerebrosidase (GBA) protein. Our previous…”
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A new horizon in the phosphorylated sites of AGA: the structural impact of C163S mutation in aspartylglucosaminuria through molecular dynamics simulation by Balasundaram, Ambritha, Ramireddy, Sriroopreddy, S., Udhaya Kumar, D., Thirumal Kumar, Tayubi, Iftikhar Aslam, Zayed, Hatem, C., George Priya Doss

“…Aspartylglucosaminuria (AGU) is a lysosomal storage disorder caused by insufficient aspartylglucosaminidase (AGA) activity leading to chronic…”
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Elucidating the functional impact of G137V and G144R variants in Maroteaux Lamy’s Syndrome by Molecular Dynamics Simulation by Madhana Priya, N., Archana Pai, P., Thirumal Kumar, D., Gnanasambandan, R., Magesh, R.

“…Mucopolysaccharidoses VI (Maroteaux Lamy syndrome) is a metabolic disorder due to the loss of enzyme activity of N -acetyl galactosamine-4-sulphatase arising…”
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