AgI‐promoted one‐pot synthesis of aminoindolizines via sequential Mannich‐Grignard addition and intramolecular cyclization in water

AgI‐promoted one‐pot synthesis of aminoindolizines via sequential Mannich‐Grignard addition and intramolecular cyclization in water

The efficient synthesis of aminoindolizines in ecofriendly water with broad substrate scope from the mild and readily available AgI‐catalyzed one‐pot three‐component reaction of pyridine‐2‐carboxaldehyde, secondary amines, and terminal alkynes proceeds through the sequential Mannich‐Grignard additio...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry Vol. 58; no. 3; pp. 900 - 904
Main Authors: Guguloth, Veeranna, Balaboina, Ramesh, Paidakula, Suresh, Thirukovela, Narasimha S., Vadde, Ravinder
Format: Journal Article
Language:English
Published: Chichester, UK John Wiley & Sons, Inc 01-03-2021
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Subjects:
Alkynes
Amines
Substrates
Synthesis
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Summary:The efficient synthesis of aminoindolizines in ecofriendly water with broad substrate scope from the mild and readily available AgI‐catalyzed one‐pot three‐component reaction of pyridine‐2‐carboxaldehyde, secondary amines, and terminal alkynes proceeds through the sequential Mannich‐Grignard addition as well as intramolecular cyclization was reported for the first time.
Bibliography:Funding information
University Grants Commission of Inida
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4184