Search Results - "Thiru, Sathia"

TNFR1- and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury by Al-Lamki, Rafia S, Wang, Jun, Vandenabeele, Peter, Bradley, J. Andrew, Thiru, Sathia, Luo, Dianghong, Min, Wang, Pober, Jordan S, Bradley, John R

“…In normal kidney, TNFR1 is expressed in glomerular and peritubular capillary EC, and some tubular cells, and colocalizes with inactive apoptosis…”
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Renin Enhancer Is Critical for Control of Renin Gene Expression and Cardiovascular Function by Adams, David J., Head, Geoffrey A., Markus, M. Andrea, Lovicu, Frank J., van der Weyden, Louise, Köntgen, Frank, Arends, Mark J., Thiru, Sathia, Mayorov, Dmitry N., Morris, Brian J.

“…The important cardiovascular regulator renin contains a strong in vitro enhancer 2.7 kb upstream of its gene. Here we tested the in vivo role of the mouse…”
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Histamine Antagonizes Tumor Necrosis Factor (TNF) Signaling by Stimulating TNF Receptor Shedding from the Cell Surface and Golgi Storage Pool by Wang, Jun, Al-Lamki, Rafia S., Zhang, Hui, Kirkiles-Smith, Nancy, Gaeta, Mary Lou, Thiru, Sathia, Pober, Jordan S., Bradley, John R.

“…Tumor necrosis factor (TNF) activates pro-inflammatory functions of vascular endothelial cells (EC) through binding to receptor type 1 (TNFR1) molecules…”
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Expression of Tumor Necrosis Factor Receptors in Normal Kidney and Rejecting Renal Transplants by Al-Lamki, Rafia S, Wang, Jun, Skepper, Jeremy N, Thiru, Sathia, Pober, Jordan S, Bradley, John R

“…Activation of the TNF signal transduction cascade is initiated by the interaction of TNF with either of two cell surface receptors, TNFR-1 and TNFR-2. The…”
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The Golgi Association of Endothelial Nitric Oxide Synthase Is Necessary for the Efficient Synthesis of Nitric Oxide by Sessa, William C., Garca-Cardea, Guillermo, Liu, Jianwei, Keh, Agnes, Pollock, Jennifer S., Bradley, John, Thiru, Sathia, Braverman, Irwin M., Desai, Kaushik M.

“…The particulate enzyme, endothelial nitric oxide synthase (eNOS), produces nitric oxide to maintain normal vasodilator tone in blood vessels. In this study, we…”
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Polycystin: In vitro Synthesis, in vivo Tissue Expression, and Subcellular Localization Identifies a Large Membrane-Associated Protein by Ibraghimov-Beskrovnaya, Oxana, Dackowski, William R., Foggensteiner, Lukas, Coleman, Nick, Thiru, Sathia, Petry, Linda R., Burn, Timothy C., Connors, Timothy D., Van Raay, Terence, Bradley, John, Qian, Feng, Onuchic, Luiz F., Watnick, Terry J., Piontek, Klaus, Hakim, Raymond M., Landes, Gregory M., Germino, Gregory G., Sandford, Richard, Klinger, Katherine W.

“…The primary structure of polycystin predicts a large integral membrane protein with multiple cell recognition motifs, but its function remains unknown. Insight…”
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Expression of Silencer of Death Domains and Death-Receptor-3 in Normal Human Kidney and in Rejecting Renal Transplants by Al-Lamki, Rafia S., Wang, Jun, Thiru, Sathia, Pritchard, Nicholas R., Bradley, J. Andrew, Pober, Jordan S., Bradley, John R.

“…We have previously reported the pattern of cellular expression of tumor necrosis factor receptors (TNFR) in human kidney and their altered expression in…”
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Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys by Tietjen, Gregory T, Hosgood, Sarah A, DiRito, Jenna, Cui, Jiajia, Deep, Deeksha, Song, Eric, Kraehling, Jan R, Piotrowski-Daspit, Alexandra S, Kirkiles-Smith, Nancy C, Al-Lamki, Rafia, Thiru, Sathia, Bradley, J Andrew, Saeb-Parsy, Kourosh, Bradley, John R, Nicholson, Michael L, Saltzman, W Mark, Pober, Jordan S

“…Ex vivo normothermic machine perfusion (NMP) is a new clinical strategy to assess and resuscitate organs likely to be declined for transplantation, thereby…”
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A Case of Thrombotic Microangiopathy and Acute Sarcoidosis by Martinelli, Anthony W., Dunn, William, McClure, Mark E., Walker, Ieuan, Stewart, Andrew, Karia, Sumit, Preston, Stephen D., Thiru, Sathia, Torpey, Nicholas, Ojha, Sanjay, Symington, Emily, Nathan, James A.

“…Although sarcoidosis is an established cause of multiorgan dysfunction, acute presentation with thrombotic microangiopathy resulting in severe renal and…”
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Lysis of cold‐storage‐induced microvascular obstructions for ex vivo revitalization of marginal human kidneys by DiRito, Jenna R., Hosgood, Sarah A., Reschke, Melanie, Albert, Claire, Bracaglia, Laura G., Ferdinand, John R., Stewart, Benjamin J., Edwards, Christopher M., Vaish, Anand G., Thiru, Sathia, Mulligan, David C., Haakinson, Danielle J., Clatworthy, Menna R., Saltzman, W. Mark, Pober, Jordan S., Nicholson, Michael L., Tietjen, Gregory T.

“…Thousands of kidneys from higher‐risk donors are discarded annually because of the increased likelihood of complications posttransplant. Given the severe organ…”
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Signaling through tumor necrosis receptor 2 induces stem cell marker in CD133+ regenerating tubular epithelial cells in acute cell‐mediated rejection of human renal allografts by Bradley, John R., Wang, Jun, Bardsley, Victoria, Broecker, Verena, Thiru, Sathia, Pober, Jordan S., Al‐Lamki, Rafia S.

“…Tumor necrosis factor receptor 2 (TNFR2) is strongly upregulated on renal tubular epithelial cells by acute cell‐mediated rejection (ACR. In human kidney organ…”
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Myeloperoxidase autoantibodies distinguish vasculitis mediated by anti‐neutrophil cytoplasm antibodies from immune complex disease in MRL/Mp‐ lpr/lprmice: a spontaneous model for human microscopic angiitis by Harper, Janice M., Thiru, Sathia, Lockwood, C. Martin, Cooke, Anne

“…Anti‐neutrophil cytoplasm antibodies (ANCA) with specificity for myeloperoxidase (MPO) occur in the sera of patients with microscopic angiitis, an autoimmune…”
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Cyclosporine: five years' experience in cadaveric renal transplantation by Merion, R M, White, D J, Thiru, S, Evans, D B, Calne, R Y

“…Using a retrospective analysis we compared 79 recipients of cadaveric renal allografts who were treated with cyclosporine as the sole initial immunosuppressant…”
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Alemtuzumab (CAMPATH 1H) Induction Therapy in Cadaveric Kidney Transplantation—Efficacy and Safety at Five Years by Watson, Christopher J. E., Bradley, J. Andrew, Friend, Peter J., Firth, John, Taylor, Craig J., Bradley, John R., Smith, Kenneth G. C., Thiru, Sathia, Jamieson, Neville V., Hale, Geoff, Waldmann, Herman, Calne, Roy

“…Alemtuzumab is a powerful lymphocyte depleting antibody currently being evaluated in solid organ transplantation. This paper describes 5‐year results of a…”
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TL1A Both Promotes and Protects from Renal Inflammation and Injury by AL-LAMKI, Rafia S, JUN WANG, POBER, Jordan S, BRADLEY, John R, TOLKOVSKY, Aviva M, BRADLEY, J. Andrew, GRIFFIN, Jules L, THIRU, Sathia, WANG, Eddie C. Y, BOLTON, Eleanor, WANG MIN, MOORE, Paul

“…Death receptor 3 (DR3), a member of the TNF receptor (TNFR) superfamily, is induced in human renal tubular epithelial cells (TEC) in response to injury. This…”
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Complement Abnormalities in Acquired Lipodystrophy Revisited by Savage, David B., Semple, Robert K., Clatworthy, Menna R., Lyons, Paul A., Morgan, B. Paul, Cochran, Elaine K., Gorden, Phillip, Raymond-Barker, Philippa, Murgatroyd, Peter R., Adams, Claire, Scobie, Ian, Mufti, Ghulam J., Alexander, Graeme J. M., Thiru, Sathia, Murano, Incoronata, Cinti, Saverio, Chaudhry, Afzal N., Smith, Kenneth G. C., O'Rahilly, Stephen

“…Context: Lipodystrophy is a heterogeneous condition characterized by an inherited or acquired deficiency in the number of adipocytes required for the storage…”
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Life-supporting pig-to-primate renal xenotransplantation using genetically modified donors by ZAIDI, A, SCHMOECKEL, M, WHITE, D, FRIEND, P, BHATTI, F, WATERWORTH, P, TOLAN, M, COZZI, E, CHAVEZ, G, LANGFORD, G, THIRU, S, WALLWORK, J

“…In order to circumvent the complement-mediated hyperacute rejection of discordant xenografts, a colony of pigs transgenic for the human regulator of complement…”
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Long-term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts by COZZI, E, BHATTI, F, OSTLIE, D, WALLWORK, J, WHITE, D. J. G, FRIEND, P. J, SCHMOECKEL, M, CHAVEZ, G, SMITH, K. G. C, ZAIDI, A, BRADLEY, J. R, THIRU, S, GODDARD, M, VIAL, C

“…Recently, there has been a resumed interest in clinical xenotransplantation using pig organs. However, no data are available yet regarding the capacity of…”
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Sarcoid-like granulomatous disease following etanercept treatment for RA by Kudrin, Alex, Chilvers, Edwin R, Ginawi, Amel, Hazleman, Brian L, Griffiths, Meryl H, Thiru, Sathia, Ostor, Andrew J K

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Maintenance triple immunosuppression with cyclosporin A, mycophenolate sodium and steroids allows prolonged survival of primate recipients of hDAF porcine renal xenografts by Cozzi, Emanuele, Vial, Conrad, Ostlie, Daniel, Farah, Bhatti, Chavez, Gilda, Smith, Kenneth G. C., Bradley, John R., Thiru, Sathia, . Davies, Hugh F. S, Wallwork, John, White, David J. G., Goddard, Martin, Friend, Peter J.

“…:  To date, the best results in life‐supporting pig‐to‐primate renal xenotransplantation have been obtained in recipients exposed to long‐term…”
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