Search Results - "Thirman, Michael J"

Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia by Lin, Shan, Luo, Roger T., Ptasinska, Anetta, Kerry, Jon, Assi, Salam A., Wunderlich, Mark, Imamura, Toshihiko, Kaberlein, Joseph J., Rayes, Ahmad, Althoff, Mark J., Anastasi, John, O’Brien, Maureen M., Meetei, Amom Ruhikanta, Milne, Thomas A., Bonifer, Constanze, Mulloy, James C., Thirman, Michael J.

“…The t(4;11)(q21;q23) fuses mixed-lineage leukemia (MLL) to AF4, the most common MLL-fusion partner. Here we show that MLL fused to murine Af4, highly conserved…”
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Distinct microRNA expression profiles in acute myeloid leukemia with common translocations by Li, Zejuan, Lu, Jun, Sun, Miao, Mi, Shuangli, Zhang, Hao, Luo, Roger T, Chen, Ping, Wang, Yungui, Yan, Ming, Qian, Zhijian, Neilly, Mary Beth, Jin, Jie, Zhang, Yanming, Bohlander, Stefan K, Zhang, Dong-Er, Larson, Richard A, Le Beau, Michelle M, Thirman, Michael J, Golub, Todd R, Rowley, Janet D, Chen, Jianjun

“…MicroRNAs (miRNAs) are postulated to be important regulators in cancers. Here, we report a genome-wide miRNA expression analysis in 52 acute myeloid leukemia…”
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Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis by Jeong, Jong Jin, Gu, Xiaorong, Nie, Ji, Sundaravel, Sriram, Liu, Hui, Kuo, Wen-Liang, Bhagat, Tushar D, Pradhan, Kith, Cao, John, Nischal, Sangeeta, McGraw, Kathy L, Bhattacharyya, Sanchari, Bishop, Michael R, Artz, Andrew, Thirman, Michael J, Moliterno, Alison, Ji, Peng, Levine, Ross L, Godley, Lucy A, Steidl, Ulrich, Bieker, James J, List, Alan F, Saunthararajah, Yogen, He, Chuan, Verma, Amit, Wickrema, Amittha

“…Even though the Ten-eleven translocation (TET) enzymes catalyze the generation of 5-hydroxymethylcytosines required for lineage commitment and subsequent…”
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MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome by Wang, Qian-fei, Wu, George, Mi, Shuangli, He, Fuhong, Wu, Jun, Dong, Jingfang, Luo, Roger T., Mattison, Ryan, Kaberlein, Joseph J., Prabhakar, Shyam, Ji, Hongkai, Thirman, Michael J.

“…MLL encodes a histone methyltransferase that is critical in maintaining gene expression during embryonic development and hematopoiesis. 11q23 translocations…”
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A phase I study of selinexor in combination with high-dose cytarabine and mitoxantrone for remission induction in patients with acute myeloid leukemia by Wang, Amy Y, Weiner, Howard, Green, Margaret, Chang, Hua, Fulton, Noreen, Larson, Richard A, Odenike, Olatoyosi, Artz, Andrew S, Bishop, Michael R, Godley, Lucy A, Thirman, Michael J, Kosuri, Satyajit, Churpek, Jane E, Curran, Emily, Pettit, Kristen, Stock, Wendy, Liu, Hongtao

“…Novel therapies for patients with acute myeloid leukemia (AML) are imperative, particularly for those with high-risk features. Selinexor, an exportin 1…”
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Clinical and molecular response of acute myeloid leukemia harboring non-canonical FLT3 N676K driver mutations to contemporary FLT3 inhibitors by Roloff, Gregory W, Wen, Frank, Ramsland, Aubrianna, Artz, Andrew S, Kosuri, Satyajit, Stock, Wendy, Odenike, Olatoyosi, Larson, Richard A, Liu, Hongtao, Godley, Lucy A, Thirman, Michael J, Patel, Anand A, Daugherty, Christopher K, DuVall, Adam S, Nawas, Mariam T, Dworkin, Emily, Wool, Geoffrey D, Gurbuxani, Sandeep, Fitzpatrick, Carrie, Segal, Jeremy P, Wang, Peng, Drazer, Michael W

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Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia by Mi, Shuangli, Li, Zejuan, Chen, Ping, He, Chunjiang, Cao, Donglin, Elkahloun, Abdel, Lu, Jun, Pelloso, Luis A, Wunderlich, Mark, Huang, Hao, Luo, Roger T, Sun, Miao, He, Miao, Neilly, Mary Beth, Zeleznik-Le, Nancy J, Thirman, Michael J, Mulloy, James C, Liu, Paul P, Rowley, Janet D, Chen, Jianjun

“…MicroRNA (miRNA)-17-92 cluster (miR-17-92), containing seven individual miRNAs, is frequently amplified and overexpressed in lymphomas and various solid…”
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Consistent Deregulation of Gene Expression between Human and Murine MLL Rearrangement Leukemias by ZEJUAN LI, LUO, Roger T, LAVAU, Catherine, YANMING ZHANG, TSENG, Charles, XIUQING ZHANG, JIAN WANG, JUN YU, HUANMING YANG, SAN MING WANG, ROWLEY, Janet D, JIANJUN CHEN, SHUANGLI MI, THIRMAN, Michael J, MIAO SUN, PING CHEN, JINGYUE BAO, BETH NEILLY, Mary, JAYATHILAKA, Nimanthi, JOHNSON, Deborah S, LILI WANG

“…Important biological and pathologic properties are often conserved across species. Although several mouse leukemia models have been well established, the genes…”
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PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomas by Baron, Beverly W, Anastasi, John, Hyjek, Elizabeth M, Bies, Juraj, Reddy, Poluru L, Dong, Jingfang, Joseph, Loren, Thirman, Michael J, Wroblewski, Kristen, Wolff, Linda, Baron, Joseph M

“…Diffuse large B-cell lymphomas in humans are associated with chromosomal rearrangements (∼40%) and/or mutations disrupting autoregulation (∼16%) involving the…”
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Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes by Byun, Jung S, Wong, Madeline M, Cui, Wenwu, Idelman, Gila, Li, Quentin, De Siervi, Adriana, Bilke, Sven, Haggerty, Cynthia M, Player, Audrey, Wang, Yong Hong, Thirman, Michael J, Kaberlein, Joseph J, Petrovas, Constantinos, Koup, Richard A, Longo, Dan, Ozato, Keiko, Gardner, Kevin

“…Profiling the dynamic interaction of p300 with proximal promoters of human T cells identified a class of genes that rapidly coassemble p300 and RNA polymerase…”
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Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia by DiNardo, Courtney D, Jonas, Brian A, Pullarkat, Vinod, Thirman, Michael J, Garcia, Jacqueline S, Wei, Andrew H, Konopleva, Marina, Döhner, Hartmut, Letai, Anthony, Fenaux, Pierre, Koller, Elizabeth, Havelange, Violaine, Leber, Brian, Esteve, Jordi, Wang, Jianxiang, Pejsa, Vlatko, Hájek, Roman, Porkka, Kimmo, Illés, Árpád, Lavie, David, Lemoli, Roberto M, Yamamoto, Kazuhito, Yoon, Sung-Soo, Jang, Jun-Ho, Yeh, Su-Peng, Turgut, Mehmet, Hong, Wan-Jen, Zhou, Ying, Potluri, Jalaja, Pratz, Keith W

“…In more than 400 older patients with AML who could not receive myeloablative therapy, the incidence of composite complete remission was higher (66.4% vs. 28.3)…”
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The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia by Issa, Ghayas C., Aldoss, Ibrahim, DiPersio, John, Cuglievan, Branko, Stone, Richard, Arellano, Martha, Thirman, Michael J., Patel, Manish R., Dickens, David S., Shenoy, Shalini, Shukla, Neerav, Kantarjian, Hagop, Armstrong, Scott A., Perner, Florian, Perry, Jennifer A., Rosen, Galit, Bagley, Rebecca G., Meyers, Michael L., Ordentlich, Peter, Gu, Yu, Kumar, Vinit, Smith, Steven, McGeehan, Gerard M., Stein, Eytan M.

“…Targeting critical epigenetic regulators reverses aberrant transcription in cancer, thereby restoring normal tissue function 1 – 3 . The interaction of menin…”
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Paradoxical Effects of MLL Paralogs in MLL-Rearranged Leukemia by Thirman, Michael J.

“…Conflicting data exist on the requirement for wild-type MLL1 in MLL-rearranged leukemia. In this issue of Cancer Cell, Chen et al. describe complementary…”
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Measurable Residual Disease Response and Prognosis in Treatment-Naïve Acute Myeloid Leukemia With Venetoclax and Azacitidine by Pratz, Keith W, Jonas, Brian A, Pullarkat, Vinod, Recher, Christian, Schuh, Andre C, Thirman, Michael J, Garcia, Jacqueline S, DiNardo, Courtney D, Vorobyev, Vladimir, Fracchiolla, Nicola S, Yeh, Su-Peng, Jang, Jun Ho, Ozcan, Muhit, Yamamoto, Kazuhito, Illes, Arpad, Zhou, Ying, Dail, Monique, Chyla, Brenda, Potluri, Jalaja, Döhner, Hartmut

“…There is limited evidence on the clinical utility of monitoring measurable residual disease (MRD) in patients with acute myeloid leukemia treated with…”
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Venetoclax with azacitidine or decitabine in patients with newly diagnosed acute myeloid leukemia: Long term follow‐up from a phase 1b study by Pollyea, Daniel A., Pratz, Keith, Letai, Anthony, Jonas, Brian A., Wei, Andrew H., Pullarkat, Vinod, Konopleva, Marina, Thirman, Michael J., Arellano, Martha, Becker, Pamela S., Chyla, Brenda, Hong, Wan‐Jen, Jiang, Qi, Potluri, Jalaja, DiNardo, Courtney D.

“…This analysis represents the longest‐term follow‐up for patients with acute myeloid leukemia (AML) treated with 400 mg of venetoclax plus azacitidine or…”
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Impact of FLT3 Mutation on Outcomes after Venetoclax and Azacitidine for Patients with Treatment-Naïve Acute Myeloid Leukemia by Konopleva, Marina, Thirman, Michael J, Pratz, Keith W, Garcia, Jacqueline S, Recher, Christian, Pullarkat, Vinod, Kantarjian, Hagop M, DiNardo, Courtney D, Dail, Monique, Duan, Yinghui, Chyla, Brenda, Potluri, Jalaja, Miller, Catherine L, Wei, Andrew H

“…To evaluate efficacy and safety of venetoclax + azacitidine among treatment-naïve patients with FLT3-mutant acute myeloid leukemia. Data were pooled from…”
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Lenalidomide consolidation benefits patients with CLL receiving chemoimmunotherapy: results for CALGB 10404 (Alliance) by Byrd, John C., Ruppert, Amy S., Heerema, Nyla A., Halvorson, Alese E., Hoke, Eva, Smith, Mitchell R., Godwin, John E., Couban, Stephen, Fehniger, Todd A., Thirman, Michael J., Tallman, Martin S., Appelbaum, Frederick R., Stone, Richard M., Robinson, Sue, Chang, Julie E., Mandrekar, Sumithra J., Larson, Richard A.

“…Prior to novel targeted agents for chronic lymphocytic leukemia (CLL), the best chemoimmunotherapy regimen in patients with non-del(11q) disease was unclear…”
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The Elongation Factor ELL (Eleven-Nineteen Lysine-Rich Leukemia) Is a Selective Coregulator for Steroid Receptor Functions by Pascual-Le Tallec, Laurent, Simone, Federico, Viengchareun, Say, Meduri, Geri, Thirman, Michael J, Lombès, Marc

“…The dynamic and coordinated recruitment of coregulators by steroid receptors is critical for specific gene transcriptional activation. To identify new…”
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Retrovirus-Mediated Gene Transfer of MLL-ELL Transforms Primary Myeloid Progenitors and Causes Acute Myeloid Leukemias in Mice by Lavau, Catherine, Luo, Roger T., Du, Changchun, Thirman, Michael J.

“…The MLL-ELL fusion gene results from the translocation t(11;19)(q23;p13.1) that is associated with de novo and therapy-related acute myeloid leukemia. To study…”
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The Human BCL6 Transgene Promotes the Development of Lymphomas in the Mouse by Baron, Beverly W., Anastasi, John, Montag, Anthony, Huo, Dezheng, Baron, Rebecca M., Karrison, Theodore, Thirman, Michael J., Subudhi, Sumit K., Chin, Robert K., Felsher, Dean W., Fu, Yang-Xin, McKeithan, Timothy W., Baron, Joseph M., Rowley, Janet D.

“…BCL6, a gene on chromosome 3, band q27, encodes a zinc finger transcriptional repressor that is needed for germinal center formation and has been implicated in…”
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