Search Results - "Thirman, M J"

A novel clofarabine bridge strategy facilitates allogeneic transplantation in patients with relapsed/refractory leukemia and high-risk myelodysplastic syndromes by Locke, F, Agarwal, R, Kunnavakkam, R, van Besien, K, Larson, R A, Odenike, O, Godley, L A, Liu, H, Le Beau, M M, Gurbuxani, S, Thirman, M J, Sipkins, D, White, C, Artz, A, Stock, W

“…Patients with relapsed/refractory leukemias or advanced myelodysplastic syndrome (MDS) fare poorly following allogeneic hematopoietic cell transplant (HCT). We…”
Get full text

Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia : Correlation with scaffold attachment regions and topoisomerase II consensus binding sites by BROEKER, P. L. S, SUPER, H. G, THIRMAN, M. J, POMYKALA, H, YONEBAYASHI, Y, TANABE, S, ZELEZNIK-LE, N, ROWLEY, J. D

“…A major unresolved question for 11q23 translocations involving MLL is the chromosomal mechanism(s) leading to these translocations. We have mapped breakpoints…”
Get full text

The Elongation Domain of ELL Is Dispensable but Its ELL-Associated Factor 1 Interaction Domain Is Essential for MLL-ELL-Induced Leukemogenesis by Luo, Roger T., Lavau, Catherine, Du, Changchun, Simone, Federico, Polak, Paul E., Kawamata, Shin, Thirman, Michael J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal Translocations by Thirman, Michael J, Gill, Heidi J, Burnett, Robert C, Mbangkollo, David, McCabe, Norah R, Kobayashi, Hirofumi, Ziemin-van der Poel, Sheryl, Kaneko, Yasuhiko, Morgan, Rodman, Sandberg, Avery A, Chaganti, R.S.K, Larson, Richard A, Le Beau, Michelle M, Diaz, Manuel O, Rowley, Janet D

“…The molecular analysis of recurring structural abnormalities of chromosomes in human neoplasia has led to the identification of a number of genes involved in…”
Get full text

Rearrangements of the MLL Gene in Therapy-Related Acute Myeloid Leukemia in Patients Previously Treated With Agents Targeting DNA-Topoisomerase II by Gill Super, Heidi J., McCabe, Norah R., Thirman, Michael J., Larson, Richard A., Le Beau, Michelle M., Pedersen-Bjergaard, Jens, Philip, Preben, Diaz, Manuel O., Rowley, Janet D.

“…Chromosome band 11 q23 is frequently involved in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) de novo, as well as in myelodysplastic…”
Get full text

Cloning of ELL, a Gene that Fuses to MLL in a t(11;19)(q23;p13.1) in Acute Myeloid Leukemia by Thirman, Michael J., Levitan, Denise A., Kobayashi, Hiro, Simon, M. Celeste, Rowley, Janet D.

“…To characterize the functions of MLL fusion transcripts, we cloned the gene that fuses to MLL in the translocation t(11;19)(q23;p13.1). This translocation is…”
Get full text

Therapy-related myeloid leukemia by Thirman, M J, Larson, R A

“…One of the most serious possible consequences of cancer therapy is the development of a second cancer, especially leukemia. Several distinct subsets of…”
Get more information

Regulation of MEIS1 by distal enhancer elements in acute leukemia by Wang, Q-f, Li, Y-j, Dong, J-f, Li, B, Kaberlein, J J, Zhang, L, Arimura, F E, Luo, R T, Ni, J, He, F, Wu, J, Mattison, R, Zhou, J, Wang, C-z, Prabhakar, S, Nobrega, M A, Thirman, M J

“…Aberrant activation of the three-amino-acid-loop extension homeobox gene MEIS1 shortens the latency and accelerates the onset and progression of acute…”
Get full text

Bronchiolitis obliterans organizing pneumonia as a complication of allogeneic bone marrow transplantation by Thirman, M J, Devine, S M, O'Toole, K, Cizek, G, Jessurun, J, Hertz, M, Geller, R B

“…We report a patient who underwent two allogeneic bone marrow transplants for chronic myelogenous leukemia, initially in 1984 and again after relapse in 1990,…”
Get more information

Detection of 11q23/MLL rearrangements in infant leukemias with fluorescence in situ hybridization and molecular analysis by Martinez-Climent, J A, Thirman, M J, Espinosa, 3rd, R, Le Beau, M M, Rowley, J D

“…Cytogenetic abnormalities of band 11q23 have been found in more than 50% of infant leukemias regardless of the phenotype. Using probes for the MLL gene at…”
Get more information

Cloning of cDNAs of the MLL Gene that Detect DNA Rearrangements and Altered RNA Transcripts in Human Leukemic Cells with 11q23 Translocations by McCabe, Norah R., Burnett, Robert C., Gill, Heidi J., Thirman, Michael J., Mbangkollo, David, Kipiniak, Magdalena, van Melle, Elizabeth, Sheryl Ziemin-van Der Poel, Rowley, Janet D., Diaz, Manuel O.

“…Recurring chromosomal abnormalities involving translocations at chromosome 11 band q23 are associated with human myeloid and lymphoid leukemia as well as…”
Get full text

Induction of cytochrome CYPIA1 and formation of toxic metabolites of benzo[a]pyrene by rat aorta: a possible role in atherogenesis by Thirman, M J, Albrecht, J H, Krueger, M A, Erickson, R R, Cherwitz, D L, Park, S S, Gelboin, H V, Holtzman, J L

“…Cigarette smoking is a leading risk factor for atherosclerosis. Endothelial injury may be the initial event in this process. The carcinogenic metabolites of…”
Get full text

Retrovirus-Mediated Gene Transfer of MLL-ELL Transforms Primary Myeloid Progenitors and Causes Acute Myeloid Leukemias in Mice by Lavau, Catherine, Luo, Roger T., Du, Changchun, Thirman, Michael J.

“…The MLL-ELL fusion gene results from the translocation t(11;19)(q23;p13.1) that is associated with de novo and therapy-related acute myeloid leukemia. To study…”
Get full text

Abnormalities of chromosome band 11q23 and the MLL gene in pediatric myelomonocytic and monoblastic leukemias. Identification of the t(9;11) as an indicator of long survival by Martinez-Climent, J A, Espinosa, 3rd, R, Thirman, M J, Le Beau, M M, Rowley, J D

“…We reviewed the cytogenetic pattern of the malignant cells in 36 patients who were < 20 years of age and who had M4 and M5 leukemias, excluding M4Eo cases with…”
Get more information

Molecular analysis of the T-cell acute lymphoblastic leukemia-associated t(1;7)(p34;q34) that fuses LCK and TCRB by BURNETT, R. C, THIRMAN, M. J, ROWLEY, J. D, DIAZ, M. O

“…Previously we had characterized the t(1;7)(p34;q34) translocation from HSB-2. This translocation fused the beta T-cell receptor gene (TCRB) constant region and…”
Get full text

Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia by DiNardo, Courtney D, Jonas, Brian A, Pullarkat, Vinod, Thirman, Michael J, Garcia, Jacqueline S, Wei, Andrew H, Konopleva, Marina, Döhner, Hartmut, Letai, Anthony, Fenaux, Pierre, Koller, Elizabeth, Havelange, Violaine, Leber, Brian, Esteve, Jordi, Wang, Jianxiang, Pejsa, Vlatko, Hájek, Roman, Porkka, Kimmo, Illés, Árpád, Lavie, David, Lemoli, Roberto M, Yamamoto, Kazuhito, Yoon, Sung-Soo, Jang, Jun-Ho, Yeh, Su-Peng, Turgut, Mehmet, Hong, Wan-Jen, Zhou, Ying, Potluri, Jalaja, Pratz, Keith W

“…In more than 400 older patients with AML who could not receive myeloablative therapy, the incidence of composite complete remission was higher (66.4% vs. 28.3)…”
Get full text

EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein by Simone, Federico, Polak, Paul E., Kaberlein, Joseph J., Luo, Roger T., Levitan, Denise A., Thirman, Michael J.

“…The (11;19)(q23;p13.1) translocation in acute leukemia leads to the generation of a chimeric protein that fuses MLL to the transcriptional elongation factor…”
Get full text

Neurotoxicity of meperidine by Goetting, M G, Thirman, M J

“…Meperidine neurotoxicity manifests as shakiness, tremors, myoclonus, and seizures. It is generally seen with repeated parenteral use. We report a case of…”
Get more information

Unexplained anemia predominates despite an intensive evaluation in a racially diverse cohort of older adults from a referral anemia clinic by Artz, Andrew S, Thirman, Michael J

“…To accurately determine the causes of anemia and proportion of unexplained anemia in a racially diverse cohort of older adults after a comprehensive and…”
Get full text

Heterogeneity of breakpoints of 11q23 rearrangements in hematologic malignancies identified with fluorescence in situ hybridization by Kobayashi, Hirofumi, Espinosa, Rafael, Thirman, Michael J., Gill, Heidi J., Fernald, Anthony A., Diaz, Manuel O., Le Beau, Michelle M., Rowley, Janet D.

“…Twenty-four patients whose cells contained a variety of 11 q23 rearrangements, including translocations, insertions, and an inversion, were studied using…”
Get full text