Search Results - "Thiriot, David"

Immunogenicity generated by mRNA vaccine encoding VZV gE antigen is comparable to adjuvanted subunit vaccine and better than live attenuated vaccine in nonhuman primates by Monslow, Morgan A., Elbashir, Sayda, Sullivan, Nicole L., Thiriot, David S., Ahl, Patrick, Smith, Jeff, Miller, Elise, Cook, James, Cosmi, Scott, Thoryk, Elizabeth, Citron, Michael, Thambi, Nithya, Shaw, Christine, Hazuda, Daria, Vora, Kalpit A.

“…•LNP formulated mRNA encoding VZV gE antigen is highly immunogenic in NHP.•mRNA and protein vaccines showed comparable response magnitude and longevity in…”
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Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains by Secore, Susan, Wang, Su, Doughtry, Julie, Xie, Jinfu, Miezeiewski, Matt, Rustandi, Richard R, Horton, Melanie, Xoconostle, Rachel, Wang, Bei, Lancaster, Catherine, Kristopeit, Adam, Wang, Sheng-Ching, Christanti, Sianny, Vitelli, Salvatore, Gentile, Marie-Pierre, Goerke, Aaron, Skinner, Julie, Strable, Erica, Thiriot, David S, Bodmer, Jean-Luc, Heinrichs, Jon H

“…Clostridium difficile infections (CDI) are a leading cause of nosocomial diarrhea in the developed world. The main virulence factors of the bacterium are the…”
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Toxicity assessment of Clostridium difficile toxins in rodent models and protection of vaccination by Wang, Su, Rustandi, Richard R, Lancaster, Catherine, Hong, Laura G, Thiriot, David S, Xie, Jinfu, Secore, Susan, Kristopeit, Adam, Wang, Sheng-Ching, Heinrichs, Jon H

“…Highlights • Clostridium difficile binary toxins (CDTa and CDTb) are lethal in mice and hamsters. • Mice can be used as animal model to evaluate toxicity for…”
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Meeting report VLPNPV: Session 8: Vaccines I by Thiriot, David S

“…In Session 8 of the recent conference "Virus-Like Particle and Nano-Particle Vaccines" held at the Salk Institute in La Jolla, California (05 June 2014), four…”
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Ion-Exchange Chromatography to Analyze Components of a Clostridium difficile Vaccine by Rustandi, Richard R, Wang, Feng, Lancaster, Catherine, Kristopeit, Adam, Thiriot, David S, Heinrichs, Jon H

“…Ion-exchange (IEX) chromatography is one of many separation techniques that can be employed to analyze proteins. The separation mechanism is based on a…”
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Influence of formulation pH and suspension state on freezing-induced agglomeration of aluminum adjuvants by Salnikova, Maya S, Davis, Harrison, Mensch, Christopher, Celano, Lauren, Thiriot, David S

“…Freezing and thawing of vaccines containing aluminum adjuvants can lead to formation of aggregates and loss in vaccine potency. We sought to understand whether…”
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An in vitro culture model to study the dynamics of colonic microbiota in Syrian golden hamsters and their susceptibility to infection with Clostridium difficile by Miezeiewski, Matthew, Schnaufer, Todd, Muravsky, Michele, Wang, Su, Caro-Aguilar, Ivette, Secore, Susan, Thiriot, David S, Hsu, Charlie, Rogers, Irene, DeSantis, Todd, Kuczynski, Justin, Probst, Alexander J, Chehoud, Christel, Steger, Rachel, Warrington, Janet, Bodmer, Jean-Luc, Heinrichs, Jon H

“…Clostridium difficile infections (CDI) are caused by colonization and growth of toxigenic strains of C. difficile in individuals whose intestinal microbiota…”
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Development of a recombinant toxin fragment vaccine for Clostridium difficile infection by Karczewski, Jerzy, Zorman, Julie, Wang, Su, Miezeiewski, Matthew, Xie, Jinfu, Soring, Keri, Petrescu, Ioan, Rogers, Irene, Thiriot, David S, Cook, James C, Chamberlin, Mihaela, Xoconostle, Rachel F, Nahas, Debbie D, Joyce, Joseph G, Bodmer, Jean-Luc, Heinrichs, Jon H, Secore, Susan

“…Abstract Clostridium difficile infection (CDI) is the major cause of antibiotic-associated diarrhea and pseudomembranous colitis, a disease associated with…”
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Detecting and preventing reversion to toxicity for a formaldehyde-treated C. difficile toxin B mutant by Wang, Bei, Wang, Su, Rustandi, Richard R, Wang, Feng, Mensch, Christopher D, Hong, Laura, Kristopeit, Adam, Secore, Susan, Dornadula, Geethanjali, Kanavage, Anthony, Heinrichs, Jon H, Mach, Henryk, Blue, Jeffrey T, Thiriot, David S

“…Highlights • A C. difficile toxin B mutant with five mutations (mTcdB) has residual toxicity. • Formaldehyde can remove residual toxicity but reversion in…”
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Structure of the Coat Protein in Pf1 Bacteriophage Determined by Solid-state NMR Spectroscopy by Thiriot, David S., Nevzorov, Alexander A., Zagyanskiy, Lena, Wu, Chin H., Opella, Stanley J.

“…The atomic resolution structure of Pf1 coat protein determined by solid-state NMR spectroscopy of magnetically aligned filamentous bacteriophage particles in…”
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Flavodoxin Hydroquinone Reduces Azotobacter vinelandii Fe Protein to the All-Ferrous Redox State with a S = 0 Spin State by Lowery, Thomas J., Wilson, Phillip E., Zhang, Bo, Bunker, Jared, Harrison, Roger G., Nyborg, Andrew C., Thiriot, David, Watt, Gerald D.

“…Azotobacter vinelandii flavodoxin hydroquinone (FIdHQ) is a physiological reductant to nitrogenase supporting catalysis that is twice as energy efficient…”
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Dipolar Waves Map the Structure and Topology of Helices in Membrane Proteins by Mesleh, Michael F, Lee, Sangwon, Veglia, Gianluigi, Thiriot, David S, Marassi, Francesca M, Opella, Stanley J

“…Dipolar waves describe the structure and topology of helices in membrane proteins. The fit of sinusoids with the 3.6 residues per turn period of ideal…”
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Structural basis of the temperature transition of Pf1 bacteriophage by Thiriot, David S., Nevzorov, Alexander A., Opella, Stanley J.

“…The filamentous bacteriophage Pf1 undergoes a reversible temperature‐dependent transition that is also influenced by salt concentrations. This structural…”
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Identification of Human Vesicle Monoamine Transporter (VMAT2) Lumenal Cysteines That Form an Intramolecular Disulfide Bond by Thiriot, David S, Sievert, Michael K, Ruoho, Arnold E

“…The vesicle monoamine transporter (VMAT2) concentrates monoamine neurotransmitter into synaptic vesicles. To obtain structural information regarding this large…”
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Probing the Salmeterol Binding Site on the β2-Adrenergic Receptor Using a Novel Photoaffinity Ligand, [125I]Iodoazidosalmeterol by Rong, Yajing, Arbabian, Marty, Thiriot, David S, Seibold, Anita, Clark, Richard B, Ruoho, Arnold E

“…Salmeterol is a long-acting β2-adrenergic receptor (β2AR) agonist used clinically to treat asthma. In addition to binding at the active agonist site, it has…”
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Mutagenesis and Derivatization of Human Vesicle Monoamine Transporter 2 (VMAT2) Cysteines Identifies Transporter Domains Involved in Tetrabenazine Binding and Substrate Transport by Thiriot, David S., Ruoho, Arnold E.

“…The vesicle monoamine transporter (VMAT2) concentrates monoamine neurotransmitter into synaptic vesicles. Photoaffinity labeling, chimera analysis, and…”
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Detecting and preventing reversion to toxicity for a formaldehyde-treatedC. difficiletoxin B mutant by Wang, Bei, Wang, Su, Rustandi, Richard R, Wang, Feng, Mensch, Christopher D, Hong, Laura, Kristopeit, Adam, Secore, Susan, Dornadula, Geethanjali, Kanavage, Anthony, Heinrichs, Jon H, Mach, Henryk, Blue, Jeffrey T, Thiriot, David S

“…The toxicity ofClostridium difficilelarge clostridial toxin B (TcdB) can be reduced by many orders of magnitude by a combination of targeted point mutations…”
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Development and optimization of a high-throughput assay to measure neutralizing antibodies against Clostridium difficile binary toxin by Xie, Jinfu, Horton, Melanie, Zorman, Julie, Antonello, Joseph M, Zhang, Yuhua, Arnold, Beth A, Secore, Susan, Xoconostle, Rachel, Miezeiewski, Matthew, Wang, Su, Price, Colleen E, Thiriot, David, Goerke, Aaron, Gentile, Marie-Pierre, Skinner, Julie M, Heinrichs, Jon H

“…Clostridium difficile strains producing binary toxin, in addition to toxin A (TcdA) and toxin B (TcdB), have been associated with more severe disease and…”
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Development of a recombinant toxin fragment vaccine forClostridium difficileinfection by Karczewski, Jerzy, Zorman, Julie, Wang, Su, Miezeiewski, Matthew, Xie, Jinfu, Soring, Keri, Petrescu, Ioan, Rogers, Irene, Thiriot, David S, Cook, James C, Chamberlin, Mihaela, Xoconostle, Rachel F, Nahas, Debbie D, Joyce, Joseph G, Bodmer, Jean-Luc, Heinrichs, Jon H, Secore, Susan

“…Clostridium difficileinfection (CDI) is the major cause of antibiotic-associated diarrhea and pseudomembranous colitis, a disease associated with significant…”
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High-efficiency expression and characterization of the synaptic-vesicle monoamine transporter from baculovirus-infected insect cells by Sievert, M K, Thiriot, D S, Edwards, R H, Ruoho, A E

“…The full-length cDNA for the rat synaptic-vesicle monoamine transporter (VMAT2) containing a C-terminal polyhistidine epitope has been engineered into…”
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