Search Results - "Thireou, Trias"

New Insights for RANKL as a Proinflammatory Modulator in Modeled Inflammatory Arthritis by Papadaki, Maria, Rinotas, Vagelis, Violitzi, Foteini, Thireou, Trias, Panayotou, George, Samiotaki, Martina, Douni, Eleni

“…Receptor activator of nuclear factor-κB ligand (RANKL), a member of the Tumor Necrosis Factor (TNF) superfamily, constitutes the master regulator of osteoclast…”
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A Holistic Evolutionary and 3D Pharmacophore Modelling Study Provides Insights into the Metabolism, Function, and Substrate Selectivity of the Human Monocarboxylate Transporter 4 (hMCT4) by Papakonstantinou, Eleni, Vlachakis, Dimitrios, Thireou, Trias, Vlachoyiannopoulos, Panayiotis G, Eliopoulos, Elias

“…Monocarboxylate transporters (MCTs) are of great research interest for their role in cancer cell metabolism and their potential ability to transport…”
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Glycosidic vs. Aglycol Form of Natural Products as Putative Tyrosinase Inhibitors by Politi, Maria Evgenia, Bethanis, Kostas, Thireou, Trias, Christoforides, Elias

“…Numerous natural products and designed molecules have been evaluated as tyrosinase inhibitors that impede enzymes’ oxidation activity. In the present study,…”
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Concluding the trilogy: The interaction of 2,2′‐dihydroxy‐benzophenones and their carbonyl N‐analogues with human glutathione transferase M1‐1 face to face with the P1‐1 and A1‐1 isoenzymes involved in MDR by Georgakis, Nikolaos D., Karagiannopoulos, Dionisis A., Thireou, Trias N., Eliopoulos, Elias E., Labrou, Nikolaos E., Tsoungas, Petros G., Koutsilieris, Michael N., Clonis, Yannis D.

“…A series of 2,2′‐dihydroxybenzophenones and their carbonyl N‐analogues were studied as potential inhibitors against human glutathione transferase M1‐1…”
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Transcriptomic analysis in the TgRANKL mouse model of osteoporosis reveals miRNAs as potent regulators of bone remodeling by Ioannidou, Elisavet, Rinotas, Vagelis, Plestilova, Lenka, Jüngel, Astrid, Thireou, Trias, Douni, Eleni

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Isoenzyme- and Allozyme-Specific Inhibitors: 2,2′-Dihydroxybenzophenones and Their Carbonyl N-Analogues that Discriminate between Human Glutathione Transferase A1-1 and P1-1 Allozymes by Pouliou, Foteini M., Thireou, Trias N., Eliopoulos, Elias E., Tsoungas, Petros G., Labrou, Nikolaos E., Clonis, Yannis D.

“…The selectivity of certain benzophenones and their carbonyl N‐analogues was investigated towards the human GSTP1‐1 allozymes A, B and C involved in MDR. The…”
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2,2′-Dihydroxybenzophenones and their carbonyl N-analogues as inhibitor scaffolds for MDR-involved human glutathione transferase isoenzyme A1-1 by Perperopoulou, Fereniki D., Tsoungas, Petros G., Thireou, Trias N., Rinotas, Vagelis E., Douni, Eleni K., Eliopoulos, Elias E., Labrou, Nikolaos E., Clonis, Yannis D.

“…The MDR-involved human GSTA1-1, an important isoenzyme overexpressed in several tumors leading to chemotherapeutic-resistant tumour cells, has been targeted by…”
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Synthesis and Study of 2‑(Pyrrolesulfonylmethyl)‑N‑arylimines: A New Class of Inhibitors for Human Glutathione Transferase A1‑1 by Koutsoumpli, Georgia E, Dimaki, Virginia D, Thireou, Trias N, Eliopoulos, Elias E, Labrou, Nikolaos E, Varvounis, George I, Clonis, Yannis D

“…Overexpression of human GSTA1-1 in tumor cells is part of MDR mechanisms. We report on the synthesis of 11 pyrrole derivatives as hGSTA1-1 inhibitors starting…”
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Designer xanthone: an inhibitor scaffold for MDR-involved human glutathione transferase isoenzyme A1-1 by Zoi, Ourania G, Thireou, Trias N, Rinotas, Vagelis E, Tsoungas, Petros G, Eliopoulos, Elias E, Douni, Eleni K, Labrou, Nikolaos E, Clonis, Yannis D

“…Glutathione transferases (GSTs) are cell detoxifiers involved in multiple drug resistance (MDR), hampering the effectiveness of certain anticancer drugs. To…”
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Analysis and interpretation of dynamic FDG PET oncological studies using data reduction techniques by Pavlopoulos, Sotiris, Thireou, Trias, Kontaxakis, George, Santos, Andres

“…Dynamic positron emission tomography studies produce a large amount of image data, from which clinically useful parametric information can be extracted using…”
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A Survey of the Availability of Primary Bioinformatics Web Resources by Thireou, Trias, Spyrou, George, Atlamazoglou, Vassilis

“…The explosive growth of the bioinformatics field has led to a large amount of data and software applications publicly available as web resources. However, the…”
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Quantitative prediction of critical amino acid positions for protein folding by Thireou, Trias, Atlamazoglou, Vassilios, Papandreou, Nikolaos A, Lonquety, Mathieu, Chomilier, Jacques, Eliopoulos, Elias

“…The MIR algorithm provides an ab initio prediction of a protein's core residues. An improved version, the MIR2, is presented and validated on 3203 proteins…”
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Abstract 1161 Natural anosmia-inducing compounds for control of mosquito biting behaviors: Machine learning-assisted determination of structural determinants for ORco ligands antagonizing odorant receptor function by Iatrou, Kostas, Thireou, Trias, Kythreoti, Georgia, Liggri, Panagiota, Michaelakis, Antonios, Papachristos, Dimitrios, Tsitsanou, Katerina, Zographos, Spyros, Schulz, Stefan

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Natural volatiles preventing mosquito biting: An integrated screening platform for accelerated discovery of ORco antagonists by Kythreoti, Georgia, Thireou, Trias, Karoussiotis, Christos, Georgoussi, Zafiroula, Liggri, Panagiota GV, Papachristos, Dimitrios P., Michaelakis, Antonios, Karras, Vasileios, Zographos, Spyros E., Schulz, Stefan, Iatrou, Kostas

“…Insect olfactory receptors are heteromeric ligand-gated cation channels composed of an obligatory receptor subunit, ORco, and one of many variable subunits,…”
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Thermodynamic, crystallographic and computational studies of non-mammalian fatty acid binding to bovine β-Lactoglobulin by Rovoli, Magdalini, Thireou, Trias, Choiset, Yvan, Haertlé, Thomas, Sawyer, Lindsay, Eliopoulos, Elias, Kontopidis, George

“…The milk protein β-lactoglobulin has been widely studied since its discovery, both as a purified protein and in mixtures with other milk proteins, where its…”
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Novel Anosmia‐Inducing Compounds for Environmentally Friendly Mosquito Vector Control: Structural Determinants of ORco Ligands Antagonizing Odorant Receptor Function by Iatrou, Kostas, Kythreoti, Georgia, Thireou, Trias, Karoussiotis, Christos, Georgoussi, Zafiroula, Zographos, Spyros E., Liggri, Panagiota, Michaelakis, Antonios, Schulz, Stefan

“…Insect repellents are important means of personal protection against bites from mosquitoes carrying various pathogens. Odorant‐dependent behaviours are…”
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A Molecular Dynamics Simulation Study of the Arg206Cys Variant in DNASE1L3 Enzyme by Manio Skarlatou, Athena Andreou, Elias Christoforides, Trias Thireou

“…Genome-wide association studies (GWAS) have identified that one of the autoimmune disease-associated loci, predisposing for the development of Systemic Lupus…”
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Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice by Violitzi, Foteini, Perivolidi, Vasiliki-Iris, Thireou, Trias, Grivas, Ioannis, Haralambous, Sylva, Samiotaki, Martina, Panayotou, George, Douni, Eleni

“…We previously identified DNAJC11, a mitochondrial outer membrane protein of unknown function, as a novel genetic cause in modeled neuromuscular disease. To…”
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Computational Methods for Anticancer Drug Discovery; The MCT4 Paradigm by Papakonstantinou, Eleni, Vlachakis, Dimitrios, Thireou, Trias, Vlachoyiannopoulos, Panayiotis G, Eliopoulos, Elias

“…Modern anticancer research has employed advanced computational techniques and artificial intelligence methods for drug discovery and development, along with…”
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Glutathione analogues as substrates or inhibitors that discriminate between allozymes of the MDR-involved human glutathione transferase P1-1 by Zompra, Aikaterini, Georgakis, Nikolaos, Pappa, Eleni, Thireou, Trias, Eliopoulos, Elias, Labrou, Nikolaos, Cordopatis, Paul, Clonis, Yannis

“…ABSTRACT Glutathione (GSH) structure‐guided tripeptide analogues were designed and synthesized by solid phase technology, purified (≥95%) by RP and/or GF…”
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