Search Results - "Thio, Chris H.L."

Genome-Wide Association Scan of Serum Urea in European Populations Identifies Two Novel Loci by Thio, Chris H L, Reznichenko, Anna, van der Most, Peter J, Kamali, Zoha, Vaez, Ahmad, Smit, Johannes H, Penninx, Brenda W J H, Haller, Toomas, Mihailov, Evelin, Metspalu, Andres, Damman, Jeffrey, de Borst, Martin H, van der Harst, Pim, Verweij, Niek, Navis, Gerjan J, Gansevoort, Ron T, Nolte, Ilja M, Snieder, Harold

“…Serum urea level is a heritable trait, commonly used as a diagnostic marker for kidney function. Genome-wide association studies (GWAS) in East-Asian…”
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Diagnostic yield in adults screened at the marfan outpatient clinic using the 1996 and 2010 ghent nosologies by Aalberts, Jan J.J., Thio, Chris H.L., Schuurman, Agnes G., van Langen, Irene M., van der Pol, Bert A.E., van Tintelen, J. Peter, van den Berg, Maarten P.

“…Marfan syndrome (MFS) is diagnosed according to the Ghent nosology, which has recently been revised. In the Netherlands, evaluation for possible MFS is…”
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Familial Aggregation of CKD and Heritability of Kidney Biomarkers in the General Population: The Lifelines Cohort Study by Zhang, Jia, Thio, Chris H.L., Gansevoort, Ron T., Snieder, Harold

“…Chronic kidney disease (CKD) has a heritable component. We aimed to quantify familial aggregation of CKD in the general population and assess the extent to…”
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Mediators of the association between educational attainment and type 2 diabetes mellitus: a two-step multivariable Mendelian randomisation study by Zhang, Jia, Chen, Zekai, Pärna, Katri, van Zon, Sander K. R., Snieder, Harold, Thio, Chris H. L.

“…Aims/hypothesis Type 2 diabetes mellitus is a major health burden disproportionately affecting those with lower educational attainment (EA). We aimed to obtain…”
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Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria by Teumer, Alexander, Sieber, Karsten B., Kirsten, Holger, Bansal, Nisha, Cocca, Massimiliano, Fuchsberger, Christian, Gorski, Mathias, Hoppmann, Anselm, Li, Man, Noce, Damia, Nutile, Teresa, Sedaghat, Sanaz, Sveinbjornsson, Gardar, Tayo, Bamidele O., van der Most, Peter J., Ärnlöv, Johan, Biggs, Mary L., Burkhardt, Ralph, Chee, Miao-Ling, Chen, Mengmeng, Cheng, Ching-Yu, Coresh, Josef, Corre, Tanguy, Danesh, John, de Mutsert, Renée, Divers, Jasmin, Ehret, Georg, Endlich, Karlhans, Franco, Oscar H., Freedman, Barry I., Freitag-Wolf, Sandra, Gansevoort, Ron T., Gögele, Martin, Holm, Hilma, Foo, Valencia Hui Xian, Hwang, Shih-Jen, Ikram, M. Arfan, Jaddoe, Vincent W. V., Jakobsdottir, Johanna, Josyula, Navya Shilpa, Kähönen, Mika, Khor, Chiea-Chuen, Kiess, Wieland, Koenig, Wolfgang, Kovacs, Peter, Kronenberg, Florian, Lee, Jeannette Jen-Mai, Lehtimäki, Terho, Lim, Su-Chi, Lindgren, Cecilia M., Liu, Jianjun, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, McMullen, Barbara, Meisinger, Christa, Miliku, Kozeta, Müller-Nurasyid, Martina, Nikus, Kjell, Olafsson, Isleifur, Palmer, Nicholette D., Podgornaia, Anna I., Ponte, Belen, Rabelink, Ton J., Reilly, Dermot F., Rheinberger, Myriam, Rice, Kenneth M., Rivadeneira, Fernando, Runz, Heiko, Ryan, Kathleen A., Sabanayagam, Charumathi, Schöttker, Ben, Shi, Yuan, Strauch, Konstantin, Stumvoll, Michael, Sun, Benjamin B., Szymczak, Silke, Tan, Nicholas Y. Q., Taylor, Kent D., Teren, Andrej, Tham, Yih-Chung, Thiery, Joachim, Thio, Chris H. L., Thomsen, Hauke, Tremblay, Johanne, Uitterlinden, André G., van der Harst, Pim, Verweij, Niek, Völker, Uwe, Waldenberger, Melanie, Wang, Chaolong, Wilson, Otis D., Akilesh, Shreeram, Ho, Kevin, Parsa, Afshin, Pendergrass, Sarah A., Stefansson, Kari, Susztak, Katalin, Hung, Adriana M., Pattaro, Cristian, Köttgen, Anna

“…Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but…”
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Sex Hormones and Risk of Aneurysmal Subarachnoid Hemorrhage: A Mendelian Randomization Study by Molenberg, Rob, Thio, Chris H.L., Aalbers, Marlien W., Uyttenboogaart, Maarten, Larsson, Susanna C., Bakker, Mark K., Ruigrok, Ynte M., Snieder, Harold, van Dijk, J. Marc C.

“…The risk of aneurysmal subarachnoid hemorrhage (aSAH) is increased in postmenopausal women compared with men of similar age, suggesting a role for sex…”
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Sex Hormones and Risk of Aneurysmal Subarachnoid Hemorrhage: A Mendelian Randomization Study by Molenberg, Rob, Thio, Chris H.L., Aalbers, Marlien W., Uyttenboogaart, Maarten, Larsson, Susanna C., Bakker, Mark K., Ruigrok, Ynte M., Snieder, Harold, van Dijk, J. Marc C.

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The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents by Jaddoe, Vincent W. V., Felix, Janine F., Andersen, Anne-Marie Nybo, Charles, Marie-Aline, Chatzi, Leda, Corpeleijn, Eva, Donner, Nina, Elhakeem, Ahmed, Eriksson, Johan G., Foong, Rachel, Grote, Veit, Haakma, Sido, Hanson, Mark, Harris, Jennifer R., Heude, Barbara, Huang, Rae-Chi, Inskip, Hazel, Järvelin, Marjo-Riitta, Koletzko, Berthold, Lawlor, Deborah A., Lindeboom, Maarten, McEachan, Rosemary R. C., Mikkola, Tuija M., Nader, Johanna L. T., de Moira, Angela Pinot, Pizzi, Costanza, Richiardi, Lorenzo, Sebert, Sylvain, Schwalber, Ameli, Sunyer, Jordi, Swertz, Morris A., Vafeiadi, Marina, Vrijheid, Martine, Wright, John, Duijts, Liesbeth

“…Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to…”
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Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline by Gorski, Mathias, Jung, Bettina, Li, Yong, Matias-Garcia, Pamela R, Wuttke, Matthias, Coassin, Stefan, Thio, Chris H L, Kleber, Marcus E, Winkler, Thomas W, Wanner, Veronika, Chai, Jin-Fang, Chu, Audrey Y, Cocca, Massimiliano, Feitosa, Mary F, Ghasemi, Sahar, Hoppmann, Anselm, Horn, Katrin, Li, Man, Nutile, Teresa, Scholz, Markus, Sieber, Karsten B, Teumer, Alexander, Tin, Adrienne, Wang, Judy, Tayo, Bamidele O, Ahluwalia, Tarunveer S, Almgren, Peter, Bakker, Stephan J L, Banas, Bernhard, Bansal, Nisha, Biggs, Mary L, Boerwinkle, Eric, Bottinger, Erwin P, Brenner, Hermann, Carroll, Robert J, Chalmers, John, Chee, Miao-Li, Chee, Miao-Ling, Cheng, Ching-Yu, Coresh, Josef, de Borst, Martin H, Degenhardt, Frauke, Eckardt, Kai-Uwe, Endlich, Karlhans, Franke, Andre, Freitag-Wolf, Sandra, Gampawar, Piyush, Gansevoort, Ron T, Ghanbari, Mohsen, Gieger, Christian, Hamet, Pavel, Ho, Kevin, Hofer, Edith, Holleczek, Bernd, Xian Foo, Valencia Hui, Hutri-Kähönen, Nina, Hwang, Shih-Jen, Ikram, M Arfan, Josyula, Navya Shilpa, Kähönen, Mika, Khor, Chiea-Chuen, Koenig, Wolfgang, Kramer, Holly, Krämer, Bernhard K, Kühnel, Brigitte, Lange, Leslie A, Lehtimäki, Terho, Lieb, Wolfgang, Loos, Ruth J F, Lukas, Mary Ann, Lyytikäinen, Leo-Pekka, Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Milaneschi, Yuri, Mishra, Pashupati P, Mononen, Nina, Mychaleckyj, Josyf C, Nadkarni, Girish N, Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M, O'Donoghue, Michelle L, Orho-Melander, Marju, Pendergrass, Sarah A, Penninx, Brenda W J H, Preuss, Michael H, Psaty, Bruce M, Raffield, Laura M, Raitakari, Olli T, Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M, Rosenkranz, Alexander R, Rossing, Peter, Rotter, Jerome I, Sabanayagam, Charumathi, Schmidt, Helena, Schmidt, Reinhold

“…Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally…”
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Blood biomarkers for new-onset hypertension in midlife women: a nested case-control study by He, Zhen, Yang, Peixuan, Lin, Qiuqiang, Thio, Chris H.L., Zhang, Fan, Wang, Ruifeng, Wang, Yue, Snieder, Harold, Zhang, Qingying

“…Midlife in women is associated with an increase in prevalence of hypertension. Little is known on the risk factors of new-onset hypertension among middle-aged…”
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A Mendelian randomization cytokine screen reveals IL-13 as causal factor in risk of severe COVID-19 by Kamali, Zoha, Vonk, Judith M., Thio, Chris H.L., Vaez, Ahmad, Snieder, Harold

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Educational level and risk of chronic kidney disease: longitudinal data from the PREVEND study by Thio, Chris H L, Vart, Priya, Kieneker, Lyanne M, Snieder, Harold, Gansevoort, Ron T, Bültmann, Ute

“…Abstract Background The longitudinal association between low education and chronic kidney disease (CKD) and its underlying mechanisms is poorly characterized…”
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Observational and Genetic Evidence for Bidirectional Effects Between Red Blood Cell Traits and Diastolic Blood Pressure by He, Zhen, Chen, Zekai, de Borst, Martin H, Zhang, Qingying, Snieder, Harold, Thio, Chris H L

“…Abstract BACKGROUND Previous studies have found associations of red blood cell (RBC) traits (hemoglobin and RBC count) with blood pressure; whether these…”
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DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study by Luo, Mannan, Walton, Esther, Neumann, Alexander, Thio, Chris H. L., Felix, Janine F., IJzendoorn, Marinus H., Pappa, Irene, Cecil, Charlotte A. M.

“…Background Lateral ventricular volume (LVV) enlargement has been repeatedly linked to schizophrenia; yet, what biological factors shape LVV during early…”
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Meta-analyses identify DNA methylation associated with kidney function and damage by Schlosser, Pascal, Tin, Adrienne, Matias-Garcia, Pamela R., Thio, Chris H. L., Joehanes, Roby, Liu, Hongbo, Weihs, Antoine, Hoppmann, Anselm, Grundner-Culemann, Franziska, Min, Josine L., Adeyemo, Adebowale A., Agyemang, Charles, Aziz, Nasir A., Baccarelli, Andrea, Bochud, Murielle, Brenner, Hermann, Breteler, Monique M. B., Chaker, Layal, Chambers, John C., Cole, Shelley A., Coresh, Josef, Corre, Tanguy, Correa, Adolfo, Cox, Simon R., de Klein, Niek, Delgado, Graciela E., Domingo-Relloso, Arce, Eckardt, Kai-Uwe, Endlich, Karlhans, Evans, Kathryn L., Fornage, Myriam, Franke, Lude, Fraszczyk, Eliza, Gao, Xu, Gào, Xīn, Ghasemi, Sahar, Gieger, Christian, Greenland, Philip, Grove, Megan L., Harris, Sarah E., Hemani, Gibran, Henneman, Peter, Herder, Christian, Hurme, Mikko A., Jarvelin, Marjo-Riitta, Kardia, Sharon L. R., Kasela, Silva, Kleber, Marcus E., Koenig, Wolfgang, Kooner, Jaspal S., Kramer, Holly, Kronenberg, Florian, Kühnel, Brigitte, Lehtimäki, Terho, Lind, Lars, Liu, Dan, Liu, Yongmei, Lloyd-Jones, Donald M., Lohman, Kurt, Lorkowski, Stefan, Lu, Ake T., Marioni, Riccardo E., März, Winfried, McCartney, Daniel L., Meeks, Karlijn A. C., Milani, Lili, Mishra, Pashupati P., Navas-Acien, Ana, Nowak, Christoph, Peters, Annette, Prokisch, Holger, Psaty, Bruce M., Raitakari, Olli T., Ratliff, Scott M., Reiner, Alex P., Schöttker, Ben, Schwartz, Joel, Sedaghat, Sanaz, Smith, Jennifer A., Sotoodehnia, Nona, Stocker, Hannah R., Stringhini, Silvia, Sundström, Johan, Swenson, Brenton R., Tellez-Plaza, Maria, van Meurs, Joyce B. J., van Vliet-Ostaptchouk, Jana V., Venema, Andrea, Verweij, Niek, Wielscher, Matthias, Winkelmann, Juliane, Wolffenbuttel, Bruce H. R., Zheng, Yinan, Loh, Marie, Snieder, Harold, Levy, Daniel, Waldenberger, Melanie, Susztak, Katalin, Köttgen, Anna, Teumer, Alexander

“…Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and…”
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Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies by Gorski, Mathias, Rasheed, Humaira, Teumer, Alexander, Thomas, Laurent F, Graham, Sarah E, Sveinbjornsson, Gardar, Winkler, Thomas W, Günther, Felix, Stark, Klaus J, Chai, Jin-Fang, Tayo, Bamidele O, Wuttke, Matthias, Li, Yong, Tin, Adrienne, Ahluwalia, Tarunveer S, Ärnlöv, Johan, Åsvold, Bjørn Olav, Bakker, Stephan J L, Banas, Bernhard, Bansal, Nisha, Biggs, Mary L, Biino, Ginevra, Böhnke, Michael, Boerwinkle, Eric, Bottinger, Erwin P, Brenner, Hermann, Brumpton, Ben, Carroll, Robert J, Chaker, Layal, Chalmers, John, Chee, Miao-Li, Chee, Miao-Ling, Cheng, Ching-Yu, Chu, Audrey Y, Ciullo, Marina, Cocca, Massimiliano, Cook, James P, Coresh, Josef, Cusi, Daniele, de Borst, Martin H, Degenhardt, Frauke, Eckardt, Kai-Uwe, Endlich, Karlhans, Evans, Michele K, Feitosa, Mary F, Franke, Andre, Freitag-Wolf, Sandra, Fuchsberger, Christian, Gampawar, Piyush, Gansevoort, Ron T, Ghanbari, Mohsen, Ghasemi, Sahar, Giedraitis, Vilmantas, Gieger, Christian, Gudbjartsson, Daniel F, Hallan, Stein, Hamet, Pavel, Hishida, Asahi, Ho, Kevin, Hofer, Edith, Holleczek, Bernd, Holm, Hilma, Hoppmann, Anselm, Horn, Katrin, Hutri-Kähönen, Nina, Hveem, Kristian, Hwang, Shih-Jen, Ikram, M Arfan, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Karabegović, Irma, Khor, Chiea-Chuen, Koenig, Wolfgang, Kramer, Holly, Krämer, Bernhard K, Kühnel, Brigitte, Kuusisto, Johanna, Laakso, Markku, Lange, Leslie A, Lehtimäki, Terho, Li, Man, Lieb, Wolfgang, Lind, Lars, Lindgren, Cecilia M, Loos, Ruth J F, Lukas, Mary Ann, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Matias-Garcia, Pamela R, Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Milaneschi, Yuri, Mishra, Pashupati P, Mononen, Nina, Morris, Andrew P, Mychaleckyj, Josyf C, Nadkarni, Girish N, Naito, Mariko

“…Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or…”
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Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile by Rimbert, Antoine, Yeung, Ming W., Dalila, Nawar, Thio, Chris H.L., Yu, Haojie, Loaiza, Natalia, Oldoni, Federico, van der Graaf, Adriaan, Wang, Siqi, Said, M. Abdullah, Blauw, Lisanne L., Girardeau, Aurore, Bray, Lise, Caillaud, Amandine, Bloks, Vincent W., Marrec, Marie, Mouli, Philippe, Rensen, Patrick C.N., van de Sluis, Bart, Snieder, Harold, Di Filippo, Mathilde, van der Harst, Pim, Tybjaerg-Hansen, Anne, Zimmerman, Philippe, Cariou, Bertrand, Kuivenhoven, Jan

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Incidence, prognostic factors, and outcomes of venous thromboembolism in critically ill patients: data from two prospective cohort studies by Eck, Ruben J, Hulshof, Lisa, Wiersema, Renske, Thio, Chris H L, Hiemstra, Bart, van den Oever, Niels C Gritters, Gans, Reinold O B, van der Horst, Iwan C C, Meijer, Karina, Keus, Frederik

“…The objective of this study was to describe the prevalence, incidence, prognostic factors, and outcomes of venous thromboembolism in critically ill patients…”
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Associations of Genetic Factors, Educational Attainment, and Their Interaction With Kidney Function Outcomes by Thio, Chris H L, van Zon, Sander K R, van der Most, Peter J, Snieder, Harold, Bültmann, Ute, Gansevoort, Ron T

“…Abstract Both genetic predisposition and low educational attainment (EA) are associated with higher risk of chronic kidney disease. We examined the interaction…”
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Familial co-aggregation and shared genetics of cardiometabolic disorders and traits: data from the multi-generational Lifelines Cohort Study by Triatin, Rima D., Chen, Zekai, Ani, Alireza, Wang, Rujia, Hartman, Catharina A., Nolte, Ilja M., Thio, Chris H. L., Snieder, Harold

“…Abstract Background It is unclear to what extent genetics explain the familial clustering and the co-occurrence of distinct cardiometabolic disorders in the…”
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