Search Results - "Thimmegowda, N R"

Decarboxylative Annulation of α‑Amino Acids with β‑Ketoaldehydes by Paul, Anirudra, Thimmegowda, N. R, Galani Cruz, Thiago, Seidel, Daniel

“…Indolizidine and quinolizidine derivatives are readily assembled from l-proline or (±)-pipecolic acid and β-ketoaldehydes via a decarboxylative annulation…”
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Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high‐fat diet‐fed mice by Suk, Sujin, Kwon, Gyoo Taik, Lee, Eunjung, Jang, Woo Jung, Yang, Hee, Kim, Jong Hun, Thimmegowda, N. R., Chung, Min‐Yu, Kwon, Jung Yeon, Yang, Seunghee, Kim, Jason K., Park, Jung Han Yoon, Lee, Ki Won

“…Scope Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis and…”
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CPPF, A Novel Microtubule Targeting Anticancer Agent, Inhibits the Growth of a Wide Variety of Cancers by Han, Ho Jin, Park, Chanmi, Hwang, Joonsung, N R, Thimmegowda, Kim, Sun-Ok, Han, Junyeol, Woo, Minsik, B, Shwetha, Ryoo, In-Ja, Lee, Kyung Ho, Cha-Molstad, Hyunjoo, Kwon, Yong Tae, Kim, Bo Yeon, Soung, Nak-Kyun

“…In the past, several microtubule targeting agents (MTAs) have been developed into successful anticancer drugs. However, the usage of these drugs has been…”
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Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling by Liu, Kangdong, Park, Chanmi, Chen, Hanyong, Hwang, Joonsung, Thimmegowda, N.R., Bae, Eun Young, Lee, Ki Won, Kim, Hong-Gyum, Liu, Haidan, Soung, Nak Kyun, Peng, Cong, Jang, Jae Hyuk, Kim, Kyoon Eon, Ahn, Jong Seog, Bode, Ann M., Dong, Ziming, Kim, Bo Yeon, Dong, Zigang

“…Phosphatase and tensin homolog (PTEN) loss or mutation consistently activates the phosphatidylinositol 3‐kinase (PI3‐K)/Akt signaling pathway, which…”
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STK295900, a Dual Inhibitor of Topoisomerase 1 and 2, Induces G2 Arrest in the Absence of DNA Damage by Kim, Sun-Ok, Sakchaisri, Krisada, N. R., Thimmegowda, Soung, Nak Kyun, Jang, Jae-Hyuk, Kim, Young Sang, Lee, Kyung Sang, Kwon, Yong Tae, Asami, Yukihiro, Ahn, Jong Seog, Erikson, Raymond Leo, Kim, Bo Yeon

“…STK295900, a small synthetic molecule belonging to a class of symmetric bibenzimidazoles, exhibits antiproliferative activity against various human cancer cell…”
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A Derivative of Chrysin Suppresses Two-Stage Skin Carcinogenesis by Inhibiting Mitogen- and Stress-Activated Kinase 1 by HAIDAN LIU, JOONSUNG HWANG, AHN, Jong-Seog, BODE, Ann M, XINMIN ZHOU, YIFENG YANG, ERIKSON, Raymond L, KIM, Bo-Yeon, ZIGANG DONG, WEI LI, TAE WOONG CHOI, KANGDONG LIU, ZUNNAN HUANG, JANG, Jae-Hyuk, THIMMEGOWDA, N. R, KI WON LEE, RYOO, In-Ja

“…Mitogen- and stress-activated kinase 1 (MSK1) is a nuclear serine/threonine protein kinase that acts downstream of both extracellular signal-regulated kinases…”
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Synthesis and in vitro antiproliferative activity of novel 1-benzhydrylpiperazine derivatives against human cancer cell lines by Kumar, C.S. Ananda, Prasad, S.B. Benaka, Vinaya, K., Chandrappa, S., Thimmegowda, N.R., Kumar, Y.C. Sunil, Swarup, Sanjay, Rangappa, K.S.

“…In order to explore the antiproliferative effect associated with the piperazine framework, several 1-benzhydrylpiperazine derivatives 8( a– d), 9( a– d) and…”
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Synthesis and in vitro antiproliferative activity against human cancer cell lines of novel 5-(4-methyl-benzylidene)-thiazolidine-2,4-diones by Chandrappa, S., Benaka Prasad, S. B., Vinaya, K., Ananda Kumar, C. S., Thimmegowda, N. R., Rangappa, K. S.

“…Summary A series of novel 5-(4-methyl-benzylidene)-thiazolidine-2,4-dione derivatives 6 (a–d) and 7 (a–g) were synthesized with different substituted aromatic…”
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Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation by Thimmegowda, N.R., Nanjunda Swamy, S., Ananda Kumar, C.S., Sunil Kumar, Y.C., Chandrappa, S., Yip, George W., Rangappa, K.S.

“…A novel series of trisubstituted benzimidazole and its precursors ( 3– 7) were synthesised and characterized by using 1H NMR, LC/MS, FTIR and elemental…”
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Hirsutenone in Alnus extract inhibits akt activity and suppresses prostate cancer cell proliferation by Kang, Soouk, Kim, Jong-Eun, Li, Yan, Jung, Sung Keun, Song, Nu Ry, Thimmegowda, N.R., Kim, Bo Yeon, Lee, Hyong Joo, Bode, Ann M., Dong, Zigang, Lee, Ki Won

“…Although specific compounds found in some East Asian traditional medicines have been shown to exhibit bioactive properties, their molecular mechanisms of…”
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STK295900, a dual inhibitor of topoisomerase 1 and 2, induces G(2) arrest in the absence of DNA damage by Kim, Sun-Ok, Sakchaisri, Krisada, Thimmegowda, N R, N R, Thimmegowda, Soung, Nak Kyun, Jang, Jae-Hyuk, Kim, Young Sang, Lee, Kyung Sang, Kwon, Yong Tae, Asami, Yukihiro, Ahn, Jong Seog, Erikson, Raymond Leo, Kim, Bo Yeon

“…STK295900, a small synthetic molecule belonging to a class of symmetric bibenzimidazoles, exhibits antiproliferative activity against various human cancer cell…”
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Synthesis and in vitro cytotoxic evaluation of novel diazaspiro bicyclo hydantoin derivatives in human leukemia cells: A SAR study by Ananda Kumar, C. S., Kavitha, C. V., Vinaya, K., Prasad, S. B. Benaka, Thimmegowda, N. R., Chandrappa, S., Raghavan, Sathees C., Rangappa, K. S.

“…Summary To study the structure activity relationship (SAR) on the cytotoxic activity and probe the structural requirement for the potent antitumor activity, a…”
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Furan-2-carboxamide derivative, a novel microtubule stabilizing agent induces mitotic arrest and potentiates apoptosis in cancer cells by Shwetha, B, Sudhanva, M. Srinivasa, Jagadeesha, G.S, Thimmegowda, N.R, Hamse, Vivek K., Sridhar, B.T, Thimmaiah, K.N, Ananda Kumar, C.S, Shobith, Rangappa, Rangappa, K.S

“…[Display omitted] •SH09, induces mitotic arrest and promotes apoptosis in various cancer cells.•SH09, decreases colony formation and mitigates invasion and…”
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Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation by Kwon, Osong, Soung, Nak Kyun, Thimmegowda, N.R., Jeong, Sook Jung, Jang, Jae Hyuk, Moon, Dong-Oh, Chung, Jong Kyeong, Lee, Kyung Sang, Kwon, Yong Tae, Erikson, Raymond Leo, Ahn, Jong Seog, Kim, Bo Yeon

“…Patulin is a fungal mycotoxin of Aspergilus and Penicillium that is commonly found in rotting fruits and exerts its potential toxic effect mainly by reactive…”
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Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways by Byun, Sanguine, Lim, Semi, Mun, Ji Young, Kim, Ki Hyun, Ramadhar, Timothy R., Farrand, Lee, Shin, Seung Ho, Thimmegowda, N.R., Lee, Hyong Joo, Frank, David A., Clardy, Jon, Lee, Sam W., Lee, Ki Won

“…Bioactive phytochemicals can suppress the growth of malignant cells, and investigation of the mechanisms responsible can assist in the identification of novel…”
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A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases by Liu, Haidan, Liu, Kangdong, Huang, Zunnan, Park, Chan-Mi, Thimmegowda, N.R., Jang, Jae-Hyuk, Ryoo, In-Ja, He, Long, Kim, Sun-Ok, Oi, Naomi, Lee, Ki Won, Soung, Nak-Kyun, Bode, Ann M., Yang, Yifeng, Zhou, Xinmin, Erikson, Raymond L., Ahn, Jong-Seog, Hwang, Joonsung, Kim, Kyoon Eon, Dong, Zigang, Kim, Bo-Yeon

“…Chrysin (5,7-dihydroxyflavone), a natural flavonoid widely distributed in plants, reportedly has chemopreventive properties against various cancers. However,…”
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Hirsutenone Directly Targets PI3K and ERK to Inhibit Adipogenesis in 3T3-L1 Preadipocytes by Cheong, Lai Yee, Suk, Sujin, Thimmegowda, N. R., Chung, Min-Yu, Yang, Hee, Seo, Sang Gwon, Shwetha, B., Kim, Jong-Eun, Kwon, Jung Yeon, Kim, Bo Yeon, Lee, Ki Won

“…ABSTRACT Adipogenesis is a key driver of the expansion of adipose tissue mass that causes obesity. Hirsutenone (HST) is an active botanical diarylheptanoid…”
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Synthesis and in vivo anticancer and antiangiogenic effects of novel thioxothiazolidin-4-one derivatives against transplantable mouse tumor by Chandrappa, S, Chandru, H, Sharada, A. C, Vinaya, K, Ananda Kumar, C. S, Thimmegowda, N. R, Nagegowda, P, Karuna Kumar, M, Rangappa, K. S

“…A series of novel thioxothiazolidin-4-one derivatives 5(a-g) were synthesized by the coupling of different amines containing aliphatic, substituted aromatic,…”
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Synthesis and antiproliferative activity of substituted diazaspiro hydantoins: a structure–activity relationship study by C. S., Ananda Kumar, Prasad, S. B. Benaka, Vinaya, K., Chandrappa, S., Thimmegowda, N. R., Ranganatha, S. R., Swarup, Sanjay, Rangappa, K. S.

“…Summary In the course of structure–activity relationship studies and to explore the antiproliferative effect associated with the hydantoin framework, diversely…”
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Synthesis and antimicrobial studies of novel 1-benzhydryl-piperazine sulfonamide and carboxamide derivatives by Kumar, C S Ananda, Vinaya, K, Chandra, J Narendra Sharath, Thimmegowda, N R, Prasad, S B Benaka, Sadashiva, C T, Rangappa, K S

“…A series of novel substituted 1-benzhydryl-piperazine sulfonamide 8(a-f) and benzamides 9(a-h) were synthesized and their antimicrobial activities evaluated in…”
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