Search Results - "Thiesen, Louise"

The CaMKIIα hub ligand Ph-HTBA promotes neuroprotection after focal ischemic stroke by a distinct molecular interaction by Griem-Krey, Nane, Gauger, Stine J., Gowing, Emma K., Thiesen, Louise, Frølund, Bente, Clarkson, Andrew N., Wellendorph, Petrine

“…Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) is a potential target for acute neuroprotection due to its key role in physiological and…”
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In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1 by Thiesen, Louise, Kehler, Jan, Clausen, Rasmus P, Frølund, Bente, Bundgaard, Christoffer, Wellendorph, Petrine

“…γ-Hydroxybutyric acid (GHB) is a recreational drug, a clinically prescribed drug in narcolepsy and alcohol dependence, and an endogenous substance that binds…”
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Lack of evidence for synaptic high‐affinity γ‐hydroxybutyric acid (GHB) transport in rat brain synaptosomes and 11 Na+‐dependent SLC neurotransmitter transporters by Thiesen, Louise, Frølund, Bente, Wellendorph, Petrine

“…γ‐Hydroxybutyric acid (GHB) is an endogenous compound proposed to act as a neurotransmitter. Na+‐dependent, high‐affinity GHB transport has long been…”
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The γ-hydroxybutyric acid (GHB) analogue NCS-382 is a substrate for both monocarboxylate transporters subtypes 1 and 4 by Thiesen, Louise, Belew, Zeinu Mussa, Griem-Krey, Nane, Pedersen, Stine Falsig, Crocoll, Christoph, Nour-Eldin, Hussam Hassan, Wellendorph, Petrine

“…The small-molecule ligand (E)-2-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[7]annulen-6-ylidene)acetic acid (NCS-382) is an analogue of γ-hydroxybutyric acid (GHB)…”
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GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice by Lie, Maria EK, Gowing, Emma K, Johansen, Nina B, Dalby, Nils Ole, Thiesen, Louise, Wellendorph, Petrine, Clarkson, Andrew N

“…Ischemic stroke triggers an elevation in tonic GABA inhibition that impairs the ability of the brain to form new structural and functional cortical circuits…”
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Exploring the NCS-382 Scaffold for CaMKIIα Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKIIα Hub Domain by Tian, Yongsong, Shehata, Mohamed A., Gauger, Stine Juul, Veronesi, Carolina, Hamborg, Louise, Thiesen, Louise, Bruus-Jensen, Jesper, Royssen, Johanne Schlieper, Leurs, Ulrike, Larsen, Anne Sofie G., Krall, Jacob, Solbak, Sara M.Ø., Wellendorph, Petrine, Frølund, Bente

“…Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) is a brain-relevant kinase and an emerging drug target for ischemic stroke and neurodegenerative…”
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Discovery and Optimization of 5‑Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain by Tian, Yongsong, Shehata, Mohamed A., Gauger, Stine Juul, Ng, Clarissa K. L., Solbak, Sara, Thiesen, Louise, Bruus-Jensen, Jesper, Krall, Jacob, Bundgaard, Christoffer, Gibson, K. Michael, Wellendorph, Petrine, Frølund, Bente

“…The Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα) is a brain-relevant kinase involved in long-term potentiation and synaptic plasticity. We have…”
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Five-Membered N‑Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ‑Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters by Giraudo, Alessandro, Krall, Jacob, Bavo, Francesco, Nielsen, Birgitte, Kongstad, Kenneth T, Rolando, Barbara, De Blasio, Rossella, Gloriam, David E, Löffler, Rebekka, Thiesen, Louise, Harpsøe, Kasper, Frydenvang, Karla, Boschi, Donatella, Wellendorph, Petrine, Lolli, Marco L, Jensen, Anders A, Frølund, Bente

“…Given the heterogeneity within the γ-aminobutyric acid (GABA) receptor and transporter families, a detailed insight into the pharmacology is still relatively…”
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Pharmacological Characterization of [3H]ATPCA as a Substrate for Studying the Functional Role of the Betaine/GABA Transporter 1 and the Creatine Transporter by Al-Khawaja, Anas, Haugaard, Anne S, Marek, Ales, Löffler, Rebekka, Thiesen, Louise, Santiveri, Mònica, Damgaard, Maria, Bundgaard, Christoffer, Frølund, Bente, Wellendorph, Petrine

“…The betaine/γ-aminobutyric acid (GABA) transporter 1 (BGT1) is one of the four GABA transporters (GATs) involved in the termination of GABAergic…”
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Radiosynthesis and Evaluation of [11C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ‑Hydroxybutyric Acid Binding Sites by Jensen, Claus H, Hansen, Hanne D, Bay, Tina, Vogensen, Stine B, Lehel, Szabolcs, Thiesen, Louise, Bundgaard, Christoffer, Clausen, Rasmus P, Knudsen, Gitte M, Herth, Matthias M, Wellendorph, Petrine, Frølund, Bente

“…γ-Hydroxybutyric acid (GHB) is an endogenous neuroactive substance and proposed neurotransmitter with affinity for both low- and high-affinity binding sites. A…”
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