Search Results - "Thiesen, Hans‐Juergen"

Gene Expression Signatures for Tumor Progression, Tumor Subtype, and Tumor Thickness in Laser-Microdissected Melanoma Tissues by JAEGER, Jochen, KOCZAN, Dirk, THIESEN, Hans-Juergen, IBRAHIM, Saleh M, GROSS, Gerd, SPANG, Rainer, KUNZ, Manfred

“…Purpose: To better understand the molecular mechanisms of malignant melanoma progression and metastasis, gene expression profiling was done of primary…”
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From Free Binding Energy Calculations of SARS-CoV-2-Receptor Interactions to Cellular Immune Responses by Glocker, Michael O, Opuni, Kwabena F M, Thiesen, Hans-Juergen

“…Our study focuses on free energy calculations of SARS-CoV-2 spike protein receptor binding motives (RBMs) from wild type and variants of concern (VOCs), with…”
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Molecular discrimination of responders and nonresponders to anti-TNFalpha therapy in rheumatoid arthritis by etanercept by Koczan, Dirk, Drynda, Susanne, Hecker, Michael, Drynda, Andreas, Guthke, Reinhard, Kekow, Joern, Thiesen, Hans-Juergen

“…INTRODUCTION: About 30% of rheumatoid arthritis patients fail to respond adequately to TNFalpha-blocking therapy. There is a medical and socioeconomic need to…”
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Interferon-beta therapy in multiple sclerosis: the short-term and long-term effects on the patients’ individual gene expression in peripheral blood by Hecker, Michael, Hartmann, Christiane, Kandulski, Ole, Paap, Brigitte Katrin, Koczan, Dirk, Thiesen, Hans-Juergen, Zettl, Uwe Klaus

“…Therapy with interferon-beta (IFN-beta) is a mainstay in the management of relapsing–remitting multiple sclerosis (MS), with proven long-term effectiveness and…”
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Reassessment of blood gene expression markers for the prognosis of relapsing-remitting multiple sclerosis by Hecker, Michael, Paap, Brigitte Katrin, Goertsches, Robert Hermann, Kandulski, Ole, Fatum, Christian, Koczan, Dirk, Hartung, Hans-Peter, Thiesen, Hans-Juergen, Zettl, Uwe Klaus

“…Despite considerable advances in the treatment of multiple sclerosis, current drugs are only partially effective. Most patients show reduced disease activity…”
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Integrative modeling of transcriptional regulation in response to antirheumatic therapy by Hecker, Michael, Goertsches, Robert Hermann, Engelmann, Robby, Thiesen, Hans-Juergen, Guthke, Reinhard

“…The investigation of gene regulatory networks is an important issue in molecular systems biology and significant progress has been made by combining different…”
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mtDNA nt13708A variant increases the risk of multiple sclerosis by Yu, Xinhua, Koczan, Dirk, Sulonen, Anna-Maija, Akkad, Denis A, Kroner, Antje, Comabella, Manuel, Costa, Gianna, Corongiu, Daniela, Goertsches, Robert, Camina-Tato, Montserrat, Thiesen, Hans-Juergen, Nyland, Harald I, Mørk, Sverre J, Montalban, Xavier, Rieckmann, Peter, Marrosu, Maria G, Myhr, Kjell-Morten, Epplen, Joerg T, Saarela, Janna, Ibrahim, Saleh M

“…Mitochondrial DNA (mtDNA) polymorphism is a possible factor contributing to the maternal parent-of-origin effect in multiple sclerosis (MS) susceptibility. In…”
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The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution associated with unique expression profiles in human tissues by Lorenz, Peter, Dietmann, Sabine, Wilhelm, Thomas, Koczan, Dirk, Autran, Sandra, Gad, Sophie, Wen, Gaiping, Ding, Guohui, Li, Yixue, Rousseau-Merck, Marie-Françoise, Thiesen, Hans-Juergen

“…Expansion of multi-C2H2 domain zinc finger (ZNF) genes, including the Krüppel-associated box (KRAB) subfamily, paralleled the evolution of tetrapodes,…”
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Mechanisms of Hypoxic Gene Regulation of Angiogenesis Factor Cyr61 in Melanoma Cells by Kunz, Manfred, Moeller, Steffen, Koczan, Dirk, Lorenz, Peter, Wenger, Roland H., Glocker, Michael O., Thiesen, Hans-Juergen, Gross, Gerd, Ibrahim, Saleh M.

“…Hypoxia has a profound influence on progression and metastasis of malignant tumors. In the present report, we used the oligonucleotide microarray technique to…”
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Immunomodulatory effects of holothurian triterpene glycosides on mammalian splenocytes determined by mass spectrometric proteome analysis by Aminin, Dmitri L., Koy, Conelia, Dmitrenok, Pavel S., Müller-Hilke, Brigitte, Koczan, Dirk, Arbogast, Brian, Silchenko, Aleksandra A., Kalinin, Vladimir I., Avilov, Sergey A., Stonik, Valentin A., Collin, Peter D., Thiesen, Hans-Juergen, Deinzer, Max L., Glocker, Michael O.

“…Spleen is a prime organ in which immuno-stimulation takes place in mammalians. Proteome analysis was used to investigate the elicited effects on mouse…”
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Survey of microarray technologies suitable to elucidate transcriptional networks as exemplified by studying KRAB zinc finger gene families by Koczan, Dirk, Thiesen, Hans-Juergen

“…Current microarray systems are suitable to monitor genome‐wide expression patterns, to detect single‐nucleotide polymorphisms (SNP), to identify target genes…”
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Elevated type I interferon-like activity in a subset of multiple sclerosis patients: molecular basis and clinical relevance by Hundeshagen, Alexander, Hecker, Michael, Paap, Brigitte Katrin, Angerstein, Charlotte, Kandulski, Ole, Fatum, Christian, Hartmann, Christiane, Koczan, Dirk, Thiesen, Hans-Juergen, Zettl, Uwe Klaus

“…A subset of patients with multiple sclerosis (MS) shows an increased endogenous IFN-like activity before initiation of IFN-beta treatment. The molecular basis…”
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Expression Profiling Suggests Loss of Surface Integrity and Failure of Regenerative Repair as Major Driving Forces for Chronic Obstructive Pulmonary Disease Progression by Samaha, Eslam, Vierlinger, Klemens, Weinhappel, Wolfgang, Godnic-Cvar, Jasminka, Nöhammer, Christa, Koczan, Dirk, Thiesen, Hans-Juergen, Yanai, Hagai, Fraifeld, Vadim E, Ziesche, Rolf

“…Chronic obstructive pulmonary disease (COPD) poses a major risk for public health, yet remarkably little is known about its detailed pathophysiology…”
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ITEM-THREE analysis of a monoclonal anti-malaria antibody reveals its assembled epitope on the pfMSP119 antigen by Opuni, Kwabena F.M., Koy, Cornelia, Russ, Manuela, Reepmeyer, Maren, Danquah, Bright D., Weresow, Moritz, Alef, Astrid, Lorenz, Peter, Thiesen, Hans-Juergen, Glocker, Michael O.

“…Rapid diagnostic tests are first-line assays for diagnosing infectious diseases, such as malaria. To minimize false positive and false negative test results in…”
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Intact Transition Epitope Mapping (ITEM) by Yefremova, Yelena, Opuni, Kwabena F. M., Danquah, Bright D., Thiesen, Hans-Juergen, Glocker, Michael O.

“…Intact transition epitope mapping (ITEM) enables rapid and accurate determination of protein antigen-derived epitopes by either epitope extraction or epitope…”
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Disruption of the Interaction between Transcriptional Intermediary Factor 1β and Heterochromatin Protein 1 Leads to a Switch from DNA Hyper- to Hypomethylation and H3K9 to H3K27 Trimethylation on the MEST Promoter Correlating with Gene Reactivation by Riclet, Raphaël, Chendeb, Mariam, Vonesch, Jean-Luc, Koczan, Dirk, Thiesen, Hans-Juergen, Losson, Régine, Cammas, Florence

“…Here, we identified the imprinted mesoderm-specific transcript (MEST) gene as an endogenous TIF1β primary target gene and demonstrated that transcriptional…”
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SysZNF: the C2H2 zinc finger gene database by Ding, Guohui, Lorenz, Peter, Kreutzer, Michael, Li, Yixue, Thiesen, Hans-Juergen

“…C2H2 zinc finger (C2H2-ZNF) genes are one of the largest and most complex gene super-families in metazoan genomes, with hundreds of members in the human and…”
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Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammation by Pope, Richard M, Ma, Yingyu, Liu, Hongtao, Tu-Rapp, Hoang, Thiesen, Hans-Juergen, Ibrahim, Saleh M, Cole, Shawn M

“…The nonapoptotic functions of Fas ligation are incompletely characterized. In contrast to expectations, we show here that Fas-deficient mice developed…”
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Model Building: A Roadmap From COVID-19, Post COVID and Post Vac to Chronic Fatique Syndrome by Thiesen, Hans-Juergen

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Model Building: A Roadmap From COVID-19, Post COVID and Post Vac to Chronic Fatique Syndrome by Thiesen, Hans-Juergen

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