Search Results - "Thien, Christine"

c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses by Thien, Christine B F, Langdon, Wallace Y

“…The activation of signalling pathways by ligand engagement with transmembrane receptors is responsible for determining many aspects of cellular function and…”
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Cbl: many adaptations to regulate protein tyrosine kinases by Thien, Christine B. F, Langdon, Wallace Y

“…Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation…”
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Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions by Paolino, Magdalena, Thien, Christine B F, Gruber, Thomas, Hinterleitner, Reinhard, Baier, Gottfried, Langdon, Wallace Y, Penninger, Josef M

“…E3 ubiquitin ligases have been placed among the essential molecules involved in the regulation of T cell functions and T cell tolerance. However, it has never…”
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The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells by Rathinam, Chozhavendan, Thien, Christine B F, Langdon, Wallace Y, Gu, Hua, Flavell, Richard A

“…Hematopoietic stem cells (HSCs) are multipotent progenitors that give rise to all types of blood cells. In the present study, we document that HSC development…”
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Flt3 inhibitor AC220 is a potent therapy in a mouse model of myeloproliferative disease driven by enhanced wild-type Flt3 signaling by Taylor, Samuel J., Dagger, Samantha A., Thien, Christine B.F., Wikstrom, Matthew E., Langdon, Wallace Y.

“…High levels of expression of wild-type Flt3 characterize many hematopoietic proliferative diseases and neoplasms, providing a potential therapeutic target…”
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Dasatinib targets B-lineage cells but does not provide an effective therapy for myeloproliferative disease in c-Cbl RING finger mutant mice by Duyvestyn, Johanna M, Taylor, Samuel J, Dagger, Samantha A, Orandle, Marlene, Morse, 3rd, Herbert C, Thien, Christine B F, Langdon, Wallace Y

“…This study aimed to determine whether the multi-kinase inhibitor dasatinib would provide an effective therapy for myeloproliferative diseases (MPDs) involving…”
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Genetic Ablation of the c-Cbl Ubiquitin Ligase Domain Results in Increased Energy Expenditure and Improved Insulin Action by MOLERO, Juan C, TURNER, Nigel, THIEN, Christine B. F, LANGDON, Wallace Y, JAMES, David E, COONEY, Gregory J

“…Genetic Ablation of the c-Cbl Ubiquitin Ligase Domain Results in Increased Energy Expenditure and Improved Insulin Action Juan C. Molero 1 , Nigel Turner 1 2 ,…”
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Load-induced regulation of tendon homeostasis by SPARC, a genetic predisposition factor for tendon and ligament injuries by Wang, Tao, Wagner, Andrea, Gehwolf, Renate, Yan, Wenjin, Passini, Fabian S, Thien, Christine, Weissenbacher, Nadja, Lin, Zhen, Lehner, Christine, Teng, Huajian, Wittner, Claudia, Zheng, Qiujian, Dai, Jin, Ni, Ming, Wang, Allan, Papadimitriou, John, Leys, Toby, Tuan, Rocky S, Senck, Sasha, Snedeker, Jess G, Tempfer, Herbert, Jiang, Qing, Zheng, Ming H, Traweger, Andreas

“…Tendons and tendon interfaces have a very limited regenerative capacity, rendering their injuries clinically challenging to resolve. Tendons sense…”
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Loss of c-Cbl E3 ubiquitin ligase activity enhances the development of myeloid leukemia in FLT3-ITD mutant mice by Taylor, Samuel J, Thien, Christine B.F, Dagger, Samantha A, Duyvestyn, Johanna M, Grove, Carolyn S, Lee, Benjamin H, Gilliland, D. Gary, Langdon, Wallace Y

“…Mutations in the Fms-like tyrosine kinase 3 (FLT3) receptor tyrosine kinase (RTK) occur frequently in acute myeloid leukemia (AML), with the most common…”
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A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis–induced macrophage apoptosis by Kundu, Manikuntala, Pathak, Sushil Kumar, Kumawat, Kuldeep, Basu, Sanchita, Chatterjee, Gargi, Pathak, Shresh, Noguchi, Takuya, Takeda, Kohsuke, Ichijo, Hidenori, Thien, Christine B F, Langdon, Wallace Y, Basu, Joyoti

“…Apoptosis of Mycobacterium tuberculosis (Mtb)-infected macrophages restricts the spread of infection. Basu and colleagues delineate the signaling pathway…”
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Cyclic mechanical stimulation rescues achilles tendon from degeneration in a bioreactor system by Wang, Tao, Lin, Zhen, Ni, Ming, Thien, Christine, Day, Robert E., Gardiner, Bruce, Rubenson, Jonas, Kirk, Thomas B., Smith, David W., Wang, Allan, Lloyd, David G., Wang, Yan, Zheng, Qiujian, Zheng, Ming H.

“…ABSTRACT Physiotherapy is one of the effective treatments for tendinopathy, whereby symptoms are relieved by changing the biomechanical environment of the…”
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c-Cbl Promotes T Cell Receptor-induced Thymocyte Apoptosis by Activating the Phosphatidylinositol 3-Kinase/Akt Pathway by Thien, Christine B.F., Dagger, Samantha A., Steer, James H., Koentgen, Frank, Jansen, Elisa S., Scott, Clare L., Langdon, Wallace Y.

“…The ability of thymocytes to assess T cell receptor (TCR) signaling strength and initiate the appropriate downstream response is crucial for determining their…”
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Myeloid Leukemia Development in c-Cbl RING Finger Mutant Mice Is Dependent on FLT3 Signaling by Rathinam, Chozhavendan, Thien, Christine B.F., Flavell, Richard A., Langdon, Wallace Y.

“…Although myeloid leukemias are primarily caused by leukemic stem cells, the molecular basis of their transformation remains largely unknown. Here, by analyzing…”
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Cbl-b Is a Negative Regulator of Inflammatory Cytokines Produced by IgE-Activated Mast Cells by Gustin, Sonja E, Thien, Christine B. F, Langdon, Wallace Y

“…c-Cbl and Cbl-b E3 ubiquitin ligases are abundantly expressed in hemopoietic cells where they negatively regulate the activity and levels of many cell surface…”
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Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes by Hoyne, Gerard F, Flening, Eleanor, Yabas, Mehmet, Teh, Charis, Altin, John A, Randall, Katrina, Thien, Christine B F, Langdon, Wallace Y, Goodnow, Christopher C

“…The E3 ubiquitin ligase Cbl-b regulates T cell activation thresholds and has been associated with protecting against type 1 diabetes, but its in vivo role in…”
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The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgE-activated mast cells by Oksvold, Morten P., Dagger, Samantha A., Thien, Christine B.F., Langdon, Wallace Y.

“…The RING finger type E3 ubiquitin ligase, Cbl-b, is abundantly expressed in bone marrow-derived mast cells (BMMCs) and functions as a potent negative regulator…”
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Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion by Thien, Christine BF, Blystad, Frøydis D, Zhan, Yifan, Lew, Andrew M, Voigt, Valentina, Andoniou, Christopher E, Langdon, Wallace Y

“…Signaling from the T‐cell receptor (TCR) in thymocytes is negatively regulated by the RING finger‐type ubiquitin ligase c‐Cbl. To further investigate this…”
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RING Finger Mutations that Abolish c-Cbl-Directed Polyubiquitination and Downregulation of the EGF Receptor Are Insufficient for Cell Transformation by Thien, Christine B.F, Walker, Francesca, Langdon, Wallace Y

“…The c-Cbl protooncogene can function as a negative regulator of receptor protein tyrosine kinases (RPTKs) by targeting activated receptors for…”
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c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action by Molero, Juan C, Jensen, Thomas E, Withers, Phil C, Couzens, Michelle, Herzog, Herbert, Thien, Christine B F, Langdon, Wallace Y, Walder, Ken, Murphy, Maria A, Bowtell, David D L, James, David E, Cooney, Gregory J

“…Casitas b-lineage lymphoma (c-Cbl) is an E3 ubiquitin ligase that has an important role in regulating the degradation of cell surface receptors. In the present…”
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Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice by Murphy, Maria A., Schnall, Ralf G., Venter, Deon J., Barnett, Louise, Bertoncello, Ivan, Thien, Christine B. F., Langdon, Wallace Y., Bowtell, David D. L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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