Search Results - "Thieme, Frank"

A randomized, double-blind, placebo-controlled, dose-escalating phase I trial to evaluate safety and immunogenicity of a plant-produced, bivalent, recombinant norovirus-like particle vaccine by Leroux-Roels, Isabel, Maes, Cathy, Joye, Jasper, Jacobs, Bart, Jarczowski, Franziska, Diessner, André, Janssens, Yorick, Waerlop, Gwenn, Tamminen, Kirsi, Heinimäki, Suvi, Blazevic, Vesna, Leroux-Roels, Geert, Klimyuk, Victor, Adachi, Hiroshi, Hiruta, Kazuyuki, Thieme, Frank

“…Noroviruses (NoV) are the leading cause of epidemic acute gastroenteritis in humans worldwide and a safe and effective vaccine is needed. Here, a phase I,…”
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Immune responses in healthy adults elicited by a bivalent norovirus vaccine candidate composed of GI.4 and GII.4 VLPs without adjuvant by Waerlop, Gwenn, Janssens, Yorick, Jacobs, Bart, Jarczowski, Franziska, Diessner, André, Leroux-Roels, Geert, Klimyuk, Victor, Leroux-Roels, Isabel, Thieme, Frank

“…The development of an efficacious vaccine against norovirus is of paramount importance given its potential to reduce the global burden of norovirus-associated…”
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Quick and clean cloning: a ligation-independent cloning strategy for selective cloning of specific PCR products from non-specific mixes by Thieme, Frank, Engler, Carola, Kandzia, Romy, Marillonnet, Sylvestre

“…We have developed an efficient strategy for cloning of PCR products that contain an unknown region flanked by a known sequence. As with ligation-independent…”
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Specific Binding of the Xanthomonas campestris pv. vesicatoria AraC-Type Transcriptional Activator HrpX to Plant-Inducible Promoter Boxes by KOEBNIK, Ralf, KRÜGER, Antje, THIEME, Frank, URBAN, Alexander, BONAS, Ulla

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Analysis of new type III effectors from Xanthomonas uncovers XopB and XopS as suppressors of plant immunity by Schulze, Sebastian, Kay, Sabine, Büttner, Daniela, Egler, Monique, Eschen‐Lippold, Lennart, Hause, Gerd, Krüger, Antje, Lee, Justin, Müller, Oliver, Scheel, Dierk, Szczesny, Robert, Thieme, Frank, Bonas, Ulla

“…• The pathogenicity of the Gram‐negative plant‐pathogenic bacterium Xanthomonas campestris pv. vesicatoria (Xcv) is dependent on type III effectors (T3Es) that…”
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Insights into Genome Plasticity and Pathogenicity of the Plant Pathogenic Bacterium Xanthomonas campestris pv. vesicatoria Revealed by the Complete Genome Sequence by THIEME, Frank, KOEBNIK, Ralf, KIRCHNER, Oliver, LANZ, Christa, LINKE, Burkhard, MCHARDY, Alice C, MEYER, Folker, MITTENHUBER, Gerhard, NIES, Dietrich H, NIESBACH-KLÖSGEN, Ulla, PATSCHKOWSKI, Thomas, RÜCKERT, Christian, BEKEL, Thomas, RUPP, Oliver, SCHNEIKER, Susanne, SCHUSTER, Stephan C, VORHÖLTER, Frank-Jörg, WEBER, Ernst, PÜHLER, Alfred, BONAS, Ulla, BARTELS, Daniela, KAISER, Olaf, BERGER, Carolin, BOCH, Jens, BÜTTNER, Daniela, CALDANA, Camila, GAIGALAT, Lars, GOESMANN, Alexander, KAY, Sabine

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New Type III Effectors from Xanthomonas campestris pv. vesicatoria Trigger Plant Reactions Dependent on a Conserved N-Myristoylation Motif by Thieme, F, Szczesny, R, Urban, A, Kirchner, O, Hause, G, Bonas, U

“…Pathogenicity of the gram-negative plant pathogen Xanthomonas campestris pv. vesicatoria depends on a type III secretion system, which translocates bacterial…”
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Two Novel Type III-Secreted Proteins of Xanthomonas campestris pv. vesicatoria Are Encoded within the hrp Pathogenicity Island by Noël, Laurent, Thieme, Frank, Nennstiel, Dirk, Bonas, Ulla

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cDNA‐AFLP analysis unravels a genome‐wide hrpG‐regulon in the plant pathogen Xanthomonas campestris pv. vesicatoria by Noël, Laurent, Thieme, Frank, Nennstiel, Dirk, Bonas, Ulla

“…The Hrp type III protein secretion system is essential for pathogenicity of the Gram‐negative plant pathogen Xanthomonas campestris pv. vesicatoria. Expression…”
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XopC and XopJ, Two Novel Type III Effector Proteins from Xanthomonas campestris pv. vesicatoria by Noel, Laurent, Thieme, Frank, Gabler, Jana, Buttner, Daniela, Bonas, Ulla

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Safety and immunogenicity studies in animal models support clinical development of a bivalent norovirus-like particle vaccine produced in plants by Tusé, Daniel, Malm, Maria, Tamminen, Kirsi, Diessner, André, Thieme, Frank, Jarczowski, Franziska, Blazevic, Vesna, Klimyuk, Victor

“…•Noroviruses (NoV) are the leading cause of epidemic acute gastroenteritis in humans.•There is currently no safe and effective preventative NoV vaccine on the…”
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Type III effector proteins from the plant pathogen Xanthomonas and their role in the interaction with the host plant by Gürlebeck, Doreen, Thieme, Frank, Bonas, Ulla

“…Pathogenicity of Xanthomonas campestris pathovar (pv.) vesicatoria and most other Gram-negative bacterial plant pathogens largely depends on a type III…”
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Clinical Safety and Immunogenicity of Tumor-Targeted, Plant-Made Id-KLH Conjugate Vaccines for Follicular Lymphoma by Pastor, Fernando, Kandzia, Romy, Thieme, Frank, Krause, Dieter, Ma, Julian K.-C., Pandya, Shan, Klimyuk, Victor, Gleba, Yuri, Butler-Ransohoff, John E., López-Díaz de Cerio, Ascensión, Sancho, Susana Inogés, Langford, Nyla, Collins, Robert, Becerra, Carlos, Bendandi, Maurizio, Ku, Nora, Tusé, Daniel, Jarczowski, Franziska

“…We report the first evaluation of plant-made conjugate vaccines for targeted treatment of B-cell follicular lymphoma (FL) in a Phase I safety and…”
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Quick and clean cloning by Thieme, Frank, Marillonnet, Sylvestre

“…Identification of unknown sequences that flank known sequences of interest requires PCR amplification of DNA fragments that contain the junction between the…”
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Idiotypic Vaccination of Patients with Relapsed Follicular Lymphoma Using a Novel Vaccine Formulation Including a Tobacco Plant-Produced Tumor Specific Idiotype by Bendandi, Maurizio, Becerra, Carlos, Kuhn, Joseph, Hukic, Suncica, Langford, Nyla, Khokhar, Taizoon, Klimyuk, Victor, Gleba, Yuri, Kandzia, Romy, Thieme, Frank, Jarczowski, Franziska, Kuenstler, Jens Uwe, Vusirikala, Madhuri, Ku, Nora, Collins, Robert H.

“…Abstract 1649 Idiotypic vaccination has shown evidence of biological efficacy, clinical efficacy and clinical benefit in some subsets of patients with…”
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Single Agent Bendamustine Is An Effective Pre-Vaccine Treatment for Patients with Relapsed Follicular Lymphoma Undergoing Idiotypic Vaccination by Bendandi, Maurizio, Becerra, Carlos, Kuhn, Joseph, Hukic, Suncica, Langford, Nyla, Khokhar, Taizoon, Klimyuk, Victor, Gleba, Yuri, Kandzia, Romy, Thieme, Frank, Jarczowski, Franziska, Kuenstler, Jens Uwe, Vusirikala, Madhuri, Ku, Nora, Collins, Robert H.

“…Abstract 2691 Over the last two decades, idiotypic vaccination has shown evidence of biological efficacy, clinical efficacy and clinical benefit in some…”
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Type III effector proteins from the plant pathogen Xanthomonas and their role in the interaction with the host plant: Molecular regulation of plant function by GÜRLEBECK, Doreen, THIEME, Frank, BONAS, Ulla

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Genomic approaches in Xanthomonas campestris pv. vesicatoria allow fishing for virulence genes by Büttner, Daniela, Noël, Laurent, Thieme, Frank, Bonas, Ulla

“…Xanthomonas campestris pv. vesicatoria is an economically important pathogen of pepper and tomato and has been established as a model organism to study…”
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XopC and XopJ, Two Novel Type III Effector Proteinsfrom Xanthomonas campestris pv.vesicatoria by Noël, Laurent, Thieme, Frank, Gäbler, Jana, Büttner, Daniela, Bonas, Ulla

“…Pathogenicity of the gram-negative plant pathogen Xanthomonas campestris pv. vesicatoria depends on a type III secretion (TTS) system which translocates…”
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Genomic approaches in Xanthomonas campestris pv. vesicatoria allow fishing for virulence genes: Genome Research on Bacteria Relevant for Agriculture, Environment and Biotechnolgy by BÜTTNER, Daniela, NOËL, Laurent, THIEME, Frank, BONAS, Ulla

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