Search Results - "Thiemann, Meinolf"

Peripheral monocytes are functionally altered and invade the CNS in ALS patients by Zondler, Lisa, Müller, Kathrin, Khalaji, Samira, Bliederhäuser, Corinna, Ruf, Wolfgang P., Grozdanov, Veselin, Thiemann, Meinolf, Fundel-Clemes, Katrin, Freischmidt, Axel, Holzmann, Karlheinz, Strobel, Benjamin, Weydt, Patrick, Witting, Anke, Thal, Dietmar R., Helferich, Anika M., Hengerer, Bastian, Gottschalk, Kay-Eberhard, Hill, Oliver, Kluge, Michael, Ludolph, Albert C., Danzer, Karin M., Weishaupt, Jochen H.

“…Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease affecting primarily the upper and lower motor neurons. A common…”
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The CD40 agonist HERA-CD40L results in enhanced activation of antigen presenting cells, promoting an anti-tumor effect alone and in combination with radiotherapy by Frankish, Jamie, Mukherjee, Debayan, Romano, Erminia, Billian-Frey, Katharina, Schröder, Matthias, Heinonen, Karl, Merz, Christian, Redondo Müller, Mauricio, Gieffers, Christian, Hill, Oliver, Thiemann, Meinolf, Honeychurch, Jamie, Illidge, Tim, Sykora, Jaromir

“…The ability to modulate and enhance the anti-tumor immune responses is critical in developing novel therapies in cancer. The Tumor Necrosis Factor (TNF)…”
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Translational PBPK Modeling of the Protein Therapeutic and CD95L Inhibitor Asunercept to Develop Dose Recommendations for Its First Use in Pediatric Glioblastoma Patients by Hanke, Nina, Kunz, Claudia, Thiemann, Meinolf, Fricke, Harald, Lehr, Thorsten

“…The protein therapeutic and CD95L inhibitor asunercept is currently under clinical investigation for the treatment of glioblastoma and myelodysplastic…”
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3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival by Gülcüler Balta, Gülce S., Monzel, Cornelia, Kleber, Susanne, Beaudouin, Joel, Balta, Emre, Kaindl, Thomas, Chen, Si, Gao, Liang, Thiemann, Meinolf, Wirtz, Christian R., Samstag, Yvonne, Tanaka, Motomu, Martin-Villalba, Ana

“…The death receptor CD95 is expressed in every cancer cell, thus providing a promising tool to target cancer. Activation of CD95 can, however, lead to apoptosis…”
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Yes and PI3K Bind CD95 to Signal Invasion of Glioblastoma by Kleber, Susanne, Sancho-Martinez, Ignacio, Wiestler, Benedict, Beisel, Alexandra, Gieffers, Christian, Hill, Oliver, Thiemann, Meinolf, Mueller, Wolf, Sykora, Jaromir, Kuhn, Andreas, Schreglmann, Nina, Letellier, Elisabeth, Zuliani, Cecilia, Klussmann, Stefan, Teodorczyk, Marcin, Gröne, Hermann-Josef, Ganten, Tom M., Sültmann, Holger, Tüttenberg, Jochen, von Deimling, Andreas, Regnier-Vigouroux, Anne, Herold-Mende, Christel, Martin-Villalba, Ana

“…Invasion of surrounding brain tissue by isolated tumor cells represents one of the main obstacles to a curative therapy of glioblastoma multiforme. Here we…”
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The Death Receptor CD95 Activates Adult Neural Stem Cells for Working Memory Formation and Brain Repair by Corsini, Nina S., Sancho-Martinez, Ignacio, Laudenklos, Sabrina, Glagow, Désirée, Kumar, Sachin, Letellier, Elisabeth, Koch, Philipp, Teodorczyk, Marcin, Kleber, Susanne, Klussmann, Stefan, Wiestler, Benedict, Brüstle, Oliver, Mueller, Wolf, Gieffers, Christian, Hill, Oliver, Thiemann, Meinolf, Seedorf, Matthias, Gretz, Norbert, Sprengel, Rolf, Celikel, Tansu, Martin-Villalba, Ana

“…Adult neurogenesis persists in the subventricular zone and the dentate gyrus and can be induced upon central nervous system injury. However, the final…”
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HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality by Richards, David M, Marschall, Viola, Billian-Frey, Katharina, Heinonen, Karl, Merz, Christian, Redondo Müller, Mauricio, Sefrin, Julian P, Schröder, Matthias, Sykora, Jaromir, Fricke, Harald, Hill, Oliver, Gieffers, Christian, Thiemann, Meinolf

“…Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations,…”
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A Single-Chain-Based Hexavalent CD27 Agonist Enhances T Cell Activation and Induces Anti-Tumor Immunity by Thiemann, Meinolf, Richards, David M, Heinonen, Karl, Kluge, Michael, Marschall, Viola, Merz, Christian, Redondo Müller, Mauricio, Schnyder, Tim, Sefrin, Julian P, Sykora, Jaromir, Fricke, Harald, Gieffers, Christian, Hill, Oliver

“…Tumor necrosis factor receptor superfamily member 7 (TNFRSF7, CD27), expressed primarily by T cells, and its ligand CD27L (TNFSF7, CD70) provide co-stimulatory…”
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Dynamin-like Protein 1 Is Involved in Peroxisomal Fission by Koch, Annett, Thiemann, Meinolf, Grabenbauer, Markus, Yoon, Yisang, McNiven, Mark A, Schrader, Michael

“…The mammalian dynamin-like protein 1 (DLP1), a member of the dynamin family of large GTPases, possesses mechanochemical properties known to constrict and…”
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Abstract 4529: Neutralization of pro-apoptotic CD95L by Asunercept/APG101 does not impair anti-tumor immune responses by Merz, Christian, Sykora, Jaromir, Hussong, Rebecca, Thiemann, Meinolf, Hill, Oliver, Gieffers, Christian

“…Abstract The CD95 ligand (CD95L) is frequently overexpressed in cancers and tumor-associated endothelia, but also other immune cells like MDSCs and Tregs…”
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Abstract 1587: Generation and characterization of novel bispecific molecules combining single-chain-CD40L with anti-CEA, anti-CD95L or anti-PD-L1 targeting moieties by Schroeder, Matthias, Billian-Frey, Katharina, Sykora, Jaromir, Redondo-Mueller, Mauricio, Heinonen, Karl, Frankish, Jamie, Gieffers, Christian, Thiemann, Meinolf, Hill, Oliver

“…Abstract CD40 ligand is a member of the TNF superfamily (TNF-SF) and a key regulator of the immune system. Its cognate receptor CD40 is expressed on…”
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APG350 induces superior clustering of TRAIL receptors and shows therapeutic antitumor efficacy independent of cross-linking via Fcγ receptors by Gieffers, Christian, Kluge, Michael, Merz, Christian, Sykora, Jaromir, Thiemann, Meinolf, Schaal, René, Fischer, Carmen, Branschädel, Marcus, Abhari, Behnaz Ahangarian, Hohenberger, Peter, Fulda, Simone, Fricke, Harald, Hill, Oliver

“…Cancer cells can be specifically driven into apoptosis by activating Death-receptor-4 (DR4; TRAIL-R1) and/or Death-receptor-5 (DR5; TRAIL-R2). Albeit showing…”
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Abstract 4460: Novel bispecific molecules combining HERA-CD40L with anti-CEA or with anti-PD-L1 for targeting by Thiemann, Meinolf, Billian-Frey, Katharina, Schröder, Matthias, Merz, Christian, Sykora, Jaromir, Richards, David M., Müller, Mauricio Redondo, Sefrin, Julian P., Heinonen, Karl, Gieffers, Christian, Hill, Oliver

“…Abstract CD40 ligand is a member of the TNF superfamily and a key regulator of the immune system. Its cognate receptor CD40 is expressed on antigen-presenting…”
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Abstract 1076: Hexavalent HERA-CD40L induces a productive T cell-mediated anti-tumor immune response and shows superior activity in comparison to benchmark CD40 agonistic antibodies by Gieffers, Christian, Richards, David M., Sykora, Jaromir, Merz, Christian, Sefrin, Julian P., Billian-Frey, Katharina, Heinonen, Karl, Müller, Mauricio Redondo, Schröder, Matthias, Thiemann, Meinolf, Hill, Oliver

“…Abstract TNF Receptor Superfamily members (TNF-R-SF), including CD40, are key regulators of the immune system and have been immunotherapeutic targets for over…”
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Abstract 1760: The hexavalent CD40 agonist HERA-CD40L augments multi-level crosstalk between T cells and antigen-presenting cells by Merz, Christian, Sykora, Jaromir, Marschall, Viola, Richards, David M., Thiemann, Meinolf, Fricke, Harald, Hill, Oliver, Gieffers, Christian

“…Abstract Introduction: HERA-CD40L is a novel hexavalent CD40 agonist engineered with the HERA-Technology developed by Apogenix. We have previously shown that…”
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Abstract 4143: The novel hexavalent human GITR agonist HERA-GITRL promotes anti-tumor efficacy independent of Fc-functionality and shows superior activity compared with the monoclonal anti-GITR antibody TRX518 by Schröder, Matthias, Marshall, Viola, Thiemann, Meinolf, Richards, David M., Merz, Christian, Sykora, Jaromir, Sefrin, Julian P., Redondo-Müller, Mauricio, Heinonen, Karl, Billian-Frey, Katharina, Hill, Oliver, Gieffers, Christian

“…Abstract Glucocorticoid-induced TNFR-related protein (GITR, TNFRSF18, CD357), a TNFR-SF member, is a co-stimulatory receptor that increases anti-tumor T cell…”
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Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice by Gao, Liang, Brenner, David, Llorens-Bobadilla, Enric, Saiz-Castro, Gonzalo, Frank, Tobias, Wieghofer, Peter, Hill, Oliver, Thiemann, Meinolf, Karray, Saoussen, Prinz, Marco, Weishaupt, Jochen H, Martin-Villalba, Ana

“…Neuroinflammation is increasingly recognized as a hallmark of neurodegeneration. Activated central nervous system-resident microglia and infiltrating immune…”
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The Hexavalent CD40 Agonist HERA-CD40L Induces T-Cell-mediated Antitumor Immune Response Through Activation of Antigen-presenting Cells by Merz, Christian, Sykora, Jaromir, Marschall, Viola, Richards, David M, Heinonen, Karl, Redondo Müller, Mauricio, Thiemann, Meinolf, Schnyder, Tim, Fricke, Harald, Hill, Oliver, Gieffers, Christian

“…CD40 ligand (TNFSF5/CD154/CD40L), a member of the tumor necrosis factor (TNF) superfamily is a key regulator of the immune system. The cognate receptor CD40…”
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Abstract 464: Methylation of a single CpG site in the CD95-ligand promoter is a biomarker predicting the response to therapy with APG101 in glioblastoma by Gieffers, Christian, Kunz, Claudia, Sykora, Jaromir, Merz, Christian, Thiemann, Meinolf, Fricke, Harald, Wiestler, Benedikt, Wick, Wolfgang

“…Abstract CD95 (APO-1/Fas) is a member of the Tumor Necrosis Factor Receptor Super Family. Binding of CD95-ligand (CD95L) to CD95 triggers intracellular signal…”
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Abstract 1688: HERA-CD40L: A novel hexavalent CD40 agonist with superior biological activity by Merz, Christian, Sykora, Jaromir, Thiemann, Meinolf, Marschall, Viola, Heinonen, Karl H., Fricke, Harald, Gieffers, Christian, Hill, Oliver

“…Abstract Introduction: Targeted therapeutics for cancer treatment are mostly developed as antibodies, however, the natural signaling complexes of the members…”
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