Search Results - "Thielen, Nathalie G M"

Gas6/Axl Axis Activation Dampens the Inflammatory Response in Osteoarthritic Fibroblast-like Synoviocytes and Synovial Explants by Vago, Juliana P, Valdrighi, Natália, Blaney-Davidson, Esmeralda N, Hornikx, Daniel L A H, Neefjes, Margot, Barba-Sarasua, María E, Thielen, Nathalie G M, van den Bosch, Martijn H J, van der Kraan, Peter M, Koenders, Marije I, Amaral, Flávio A, van de Loo, Fons A J

“…Osteoarthritis (OA) is the most prevalent joint disease, and it is characterized by cartilage degeneration, synovitis, and bone sclerosis, resulting in…”
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Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation by Ceelen, Judith J M, Schols, Annemie M W J, Thielen, Nathalie G M, Haegens, Astrid, Gray, Douglas A, Kelders, Marco C J M, de Theije, Chiel C, Langen, Ramon C J

“…Pulmonary inflammation in response to respiratory infections can evoke muscle wasting. Increased activity of the ubiquitin (Ub)-proteasome system (UPS) and the…”
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TGFβ/BMP Signaling Pathway in Cartilage Homeostasis by Thielen, Nathalie G M, van der Kraan, Peter M, van Caam, Arjan P M

“…Cartilage homeostasis is governed by articular chondrocytes via their ability to modulate extracellular matrix production and degradation. In turn, chondrocyte…”
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Identification of Transcription Factors Responsible for a Transforming Growth Factor-β-Driven Hypertrophy-like Phenotype in Human Osteoarthritic Chondrocytes by Thielen, Nathalie G M, Neefjes, Margot, Vitters, Elly L, van Beuningen, Henk M, Blom, Arjen B, Koenders, Marije I, van Lent, Peter L E M, van de Loo, Fons A J, Blaney Davidson, Esmeralda N, van Caam, Arjan P M, van der Kraan, Peter M

“…During osteoarthritis (OA), hypertrophy-like chondrocytes contribute to the disease process. TGF-β's signaling pathways can contribute to a hypertrophy(-like)…”
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Separating friend from foe: Inhibition of TGF-β-induced detrimental SMAD1/5/9 phosphorylation while maintaining protective SMAD2/3 signaling in OA chondrocytes by Thielen, Nathalie G.M., van Caam, Arjan P.M., v. Beuningen, Henk M., Vitters, Elly L., van den Bosch, Martijn H.J., Koenders, Marije I., van de Loo, Fons A.J., Blaney Davidson, Esmeralda N., van der Kraan, Peter M.

“…Transforming growth factor-β (TGF-β) signaling via SMAD2/3 is crucial to control cartilage homeostasis. However, TGF-β can also have detrimental effects by…”
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An Improved Diagnostic Tool to Predict Cartilage Formation in an Osteoarthritic Joint Environment by Margot, Neefjes, Bas, Housmans A C, Nathalie, Thielen G M, Henk, van Beuningen M, Elly, Vitters L, Guus, van den Akker G H, Tim, Welting J M, Arjan, van Caam P M, Peter, van der Kraan M

“…Osteoarthritis (OA) is characterized by progressive articular cartilage loss. Due to the chondrogenic potential of human mesenchymal stromal cells (MSCs),…”
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Cell-integrated serum-induced signalling patterns can differentiate between hand and knee osteoarthritis patients by Neefjes, Margot, Housmans, Bas A C, Kaffa, Charlotte, Thielen, Nathalie G M, Joosten, Leo A B, van den Ende, Cornelia H M, Vitters, Elly L, van den Akker, Guus G H, Welting, Tim J M, van Caam, Arjan P M, van der Kraan, Peter M

“…Abstract Objective OA is a very heterogeneous disease. Here, we aimed to differentiate OA patients based on their serum-induced cell-integrated signalling…”
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