Search Results - "Thielen, Astrid"

Consequences of dysregulated complement regulators on red blood cells by Thielen, Astrid J.F., Zeerleder, Sacha, Wouters, Diana

“…The complement system represents the first line of defense that is involved in the clearance of pathogens, dying cells and immune complexes via opsonization,…”
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CRISPR/Cas9 generated human CD46, CD55 and CD59 knockout cell lines as a tool for complement research by Thielen, Astrid J.F., van Baarsen, Iris M., Jongsma, Marlieke L., Zeerleder, Sacha, Spaapen, Robbert M., Wouters, Diana

“…To prevent unwanted complement activation and subsequent damage, complement activation must be tightly regulated on healthy host cells. Dysregulation of the…”
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Circulating Apoptotic Microparticles in Systemic Lupus Erythematosus Patients Drive the Activation of Dendritic Cell Subsets and Prime Neutrophils for NETosis by Dieker, Jürgen, Tel, Jurjen, Pieterse, Elmar, Thielen, Astrid, Rother, Nils, Bakker, Marinka, Fransen, Jaap, Dijkman, Henry B. P. M., Berden, Jo H., de Vries, Jolanda M., Hilbrands, Luuk B., van der Vlag, Johan

“…Objective Circulating chromatin‐containing apoptotic material and/or neutrophil extracellular traps (NETs) have been proposed to be an important driving force…”
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The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation by Boer, Esther CW, Thielen, Astrid JF, Langereis, Jeroen D, Kamp, Angela, Brouwer, Mieke C, Oskam, Nienke, Jongsma, Marlieke L, Baral, April J, Spaapen, Robbert M, Zeerleder, Sacha, Vidarsson, Gestur, Rispens, Theo, Wouters, Diana, Pouw, Richard B, Jongerius, Ilse

“…Objectives The complement system is an important component of innate immunity. The alternative pathway (AP) amplification loop is considered an essential feed…”
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Complement Deposition and IgG Binding on Stored Red Blood Cells Are Independent of Storage Time by Thielen, Astrid J.F., Meulenbroek, Elisabeth M., Baas, Inge, Bruggen, Robin, Zeerleder, Sacha S., Wouters, Diana

“…Background: In the Netherlands, red blood cells (RBCs) are allowed to be stored up to 35 days at 2-6 °C in saline-adenine-glucose-mannitol (SAGM). During…”
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Only modest contribution of the amplification loop after classical pathway initiated activation on human cells by Thielen, Astrid J.F, Meulenbroek, Elisabeth M, van Baarsen, Iris M, Jongsma, Marlieke L, van Mierlo, Gerard, Brouwer, Conny, Folman, Claudia, de Haas, Masja, Zeerleder, Sacha, Spaapen, Robbert M, Wouters, Diana

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45 Expression of complement regulators on red blood cell progenitors during in vitro and in vivo erythropoiesis by de Boer, Esther C.W., Thielen, Astrid J.F., Visser, Anna, Kamp, Angela, Wouters, Diana, van den Akker, Emile, Burger, Patrick, Jongerius, Ilse, Pouw, Richard B.

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Enhanced activation of dendritic cells by autologous apoptotic microvesicles in MRL/lpr mice by Dieker, Jürgen, Hilbrands, Luuk, Thielen, Astrid, Dijkman, Henry, Berden, Jo H, van der Vlag, Johan

“…Systemic lupus erythematosus is associated with a persistent circulation of modified autoantigen-containing apoptotic debris that might be capable of breaking…”
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