Search Results - "Thiel, William H"

CaMKII (Ca2+/Calmodulin-Dependent Kinase II) in Mitochondria of Smooth Muscle Cells Controls Mitochondrial Mobility, Migration, and Neointima Formation by Nguyen, Emily K, Koval, Olha M, Noble, Paige, Broadhurst, Kim, Allamargot, Chantal, Wu, Meng, Strack, Stefan, Thiel, William H, Grumbach, Isabella M

“…OBJECTIVE—The main objective of this study is to define the mechanisms by which mitochondria control vascular smooth muscle cell (VSMC) migration and impact…”
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E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator by Guo, Ang, Wang, Yihui, Chen, Biyi, Wang, Yunhao, Yuan, Jinxiang, Zhang, Liyang, Hall, Duane, Wu, Jennifer, Shi, Yun, Zhu, Qi, Chen, Cheng, Thiel, William H, Zhan, Xin, Weiss, Robert M, Zhan, Fenghuang, Musselman, Catherine A, Pufall, Miles, Zhu, Weizhong, Au, Kin Fai, Hong, Jiang, Anderson, Mark E, Grueter, Chad E, Song, Long-Sheng

“…Junctophilin-2 (JP2) is a structural protein required for normal excitation-contraction (E-C) coupling. After cardiac stress, JP2 is cleaved by the calcium…”
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Galaxy Workflows for Web-based Bioinformatics Analysis of Aptamer High-throughput Sequencing Data by Thiel, William H

“…Development of RNA and DNA aptamers for diagnostic and therapeutic applications is a rapidly growing field. Aptamers are identified through iterative rounds of…”
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Aptamers as Diagnostic Tools in Cancer by Ruiz Ciancio, Dario, Vargas, Mauricio R, Thiel, William H, Bruno, Martin A, Giangrande, Paloma H, Mestre, María Belén

“…Cancer is the second leading cause of death worldwide. Researchers have been working hard on investigating not only improved therapeutics but also on early…”
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AptamerRunner: An accessible aptamer structure prediction and clustering algorithm for visualization of selected aptamers by Ruiz-Ciancio, Dario, Veeramani, Suresh, Singh, Rahul, Embree, Eric, Ortman, Chris, Thiel, Kristina W., Thiel, William H.

“…Aptamers are short single-stranded DNA or RNA molecules with high affinity and specificity for targets and are generated using the iterative systematic…”
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Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection by Thiel, William H, Bair, Thomas, Peek, Andrew S, Liu, Xiuying, Dassie, Justin, Stockdale, Katie R, Behlke, Mark A, Miller, Jr, Francis J, Giangrande, Paloma H

“…The broad applicability of RNA aptamers as cell-specific delivery tools for therapeutic reagents depends on the ability to identify aptamer sequences that…”
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Selection of a novel cell-internalizing RNA aptamer specific for CD22 antigen in B cell acute lymphoblastic leukemia by Ruiz-Ciancio, Dario, Lin, Li-Hsien, Veeramani, Suresh, Barros, Maya N., Sanchez, Diego, Di Bartolo, Ary Lautaro, Masone, Diego, Giangrande, Paloma H., Mestre, María Belén, Thiel, William H.

“…Despite improvements in B cell acute lymphoblastic leukemia (B-ALL) treatment, a significant number of patients experience relapse of the disease, resulting in…”
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RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome by Urak, Kevin T., Blanco, Giselle N., Shubham, Shambhavi, Lin, Li-Hsien, Dassie, Justin P., Thiel, William H., Chen, Yani, Sonkar, Vijay Kumar, Lei, Beilei, Murthy, Shubha, Gutierrez, Wade R., Wilson, Mary E., Stiber, Jonathan A., Klesney-Tait, Julia, Dayal, Sanjana, Miller, Francis J., Giangrande, Paloma H.

“…The development of multiple organ dysfunction syndrome (MODS) following infection or tissue injury is associated with increased patient morbidity and…”
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Combination of protein and cell internalization SELEX identifies a potential RNA therapeutic and delivery platform to treat EphA2-expressing tumors by Santana-Viera, Laura, Dassie, Justin P., Rosàs-Lapeña, Marta, Garcia-Monclús, Silvia, Chicón-Bosch, Mariona, Pérez-Capó, Marina, Pozo, Lidia del, Sanchez-Serra, Sara, Almacellas-Rabaiget, Olga, Maqueda-Marcos, Susana, López-Alemany, Roser, Thiel, William H., Giangrande, Paloma H., Tirado, Oscar M.

“…The EphA2 receptor tyrosine kinase is overexpressed in most solid tumors and acts as the major driver of tumorigenesis. In this study, we developed a novel…”
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Delivery of Cell-Specific Aptamers to the Arterial Wall with an Occlusion Perfusion Catheter by Udofot, Ofonime, Lin, Li-Hsien, Thiel, William H., Erwin, Megan, Turner, Emily, Miller, Francis J., Giangrande, Paloma H., Yazdani, Saami K.

“…Current strategies to prevent restenosis following endovascular treatment include the local delivery of anti-proliferative agents to inhibit vascular smooth…”
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Proarrhythmic Defects in Timothy Syndrome Require Calmodulin Kinase II by THIEL, William H, BIYI CHEN, HUND, Thomas J, KOVAL, Olha M, PUROHIT, Anil, SONG, Long-Sheng, MOHLER, Peter J, ANDERSON, Mark E

“…Timothy syndrome (TS) is a disease of excessive cellular Ca(2+) entry and life-threatening arrhythmias caused by a mutation in the primary cardiac L-type…”
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Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers by Thiel, Kristina W., Hernandez, Luiza I., Dassie, Justin P., Thiel, William H., Liu, Xiuying, Stockdale, Katie R., Rothman, Alissa M., Hernandez, Frank J., McNamara, James O., Giangrande, Paloma H.

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Optimization of RNA Aptamer SELEX Methods: Improved Aptamer Transcript 3'-End Homogeneity, PAGE Purification Yield, and Target-Bound Aptamer RNA Recovery by Narayan, Chandan, Veeramani, Suresh, Thiel, William H

“…Since its inception in the early 1990s, SELEX remains the gold standard for discovering RNA aptamers specific for proteins and small molecules. The SELEX…”
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Molecular determinants of proton-sensitive N-methyl-D-aspartate receptor gating by Low, Chian-Ming, Lyuboslavsky, Polina, French, Adam, Le, Phuong, Wyatte, Karen, Thiel, William H, Marchan, Edward M, Igarashi, Kazuei, Kashiwagi, Keiko, Gernert, Kim, Williams, Keith, Traynelis, Stephen F, Zheng, Fang

“…Extracellular protons inhibit N-methyl-D-aspartate (NMDA) receptors with an IC50 value in the physiological pH range. To identify the molecular determinants of…”
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Analyzing HT-SELEX data with the Galaxy Project tools – A web based bioinformatics platform for biomedical research by Thiel, William H., Giangrande, Paloma H.

“…[Display omitted] •Analyzing aptamer high-throughput sequencing (HTS) data using the Galaxy platform.•Pre-process aptamer HTS data to isolate the variable…”
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Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers by Thiel, Kristina W, Hernandez, Luiza I, Dassie, Justin P, Thiel, William H, Liu, Xiuying, Stockdale, Katie R, Rothman, Alissa M, Hernandez, Frank J, McNamara, 2nd, James O, Giangrande, Paloma H

“…Human epidermal growth factor receptor 2 (HER2) expression in breast cancer is associated with an aggressive phenotype and poor prognosis, making it an…”
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Cell-internalization SELEX: method for identifying cell-internalizing RNA aptamers for delivering siRNAs to target cells by Thiel, William H, Thiel, Kristina W, Flenker, Katie S, Bair, Tom, Dupuy, Adam J, McNamara, 2nd, James O, Miller, Francis J, Giangrande, Paloma H

“…After a decade of work to address cellular uptake, the principal obstacle to RNAi-based therapeutics, there is now well-deserved, renewed optimism about…”
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Identification of RNA aptamers that internalize into HPV-16 E6/E7 transformed tonsillar epithelial cells by Gourronc, Francoise A, Rockey, William M, Thiel, William H, Giangrande, Paloma H, Klingelhutz, Aloysius J

“…Abstract Human papillomavirus type 16 (HPV-16) associated oropharyngeal cancers are on a significant increase and better therapeutic strategies are needed. The…”
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AFBI assay – Aptamer Fluorescence Binding and Internalization assay for cultured adherent cells by Thiel, William H., Giangrande, Paloma H.

“…[Display omitted] •Cell-based, rapid, scalable, high-throughput aptamer screening assay.•Utilizes fluorescently labeled aptamer, microplate reader and 96-well…”
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Phosphorylation of Nox1 Regulates Association With NoxA1 Activation Domain by Streeter, Jennifer, Schickling, Brandon M, Jiang, Shuxia, Stanic, Bojana, Thiel, William H, Gakhar, Lokesh, Houtman, Jon C.D, Miller, Francis J

“…RATIONALE:Activation of Nox1 initiates redox-dependent signaling events crucial in the pathogenesis of vascular disease. Selective targeting of Nox1 is an…”
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