Search Results - "Thiel, Austin"

Menin as a hub controlling mixed lineage leukemia by Thiel, Austin T., Huang, Jing, Lei, Ming, Hua, Xianxin

“…Mixed lineage leukemia (MLL) fusion protein (FP)‐induced acute leukemia is highly aggressive and often refractory to therapy. Recent progress in the field has…”
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MLL-AF9-Induced Leukemogenesis Requires Coexpression of the Wild-Type Mll Allele by Thiel, Austin T., Blessington, Peter, Zou, Tao, Feather, Danielle, Wu, Xinjiang, Yan, Jizhou, Zhang, Hui, Liu, Zuguo, Ernst, Patricia, Koretzky, Gary A., Hua, Xianxin

“…Oncogenic fusion proteins are capable of initiating tumorigenesis, but the role of their wild-type counterparts in this process is poorly understood. The mixed…”
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Scalable Generation of Universal Platelets from Human Induced Pluripotent Stem Cells by Feng, Qiang, Shabrani, Namrata, Thon, Jonathan N., Huo, Hongguang, Thiel, Austin, Machlus, Kellie R., Kim, Kyungho, Brooks, Julie, Li, Feng, Luo, Chenmei, Kimbrel, Erin A., Wang, Jiwu, Kim, Kwang-Soo, Italiano, Joseph, Cho, Jaehyung, Lu, Shi-Jiang, Lanza, Robert

“…Human induced pluripotent stem cells (iPSCs) provide a potentially replenishable source for the production of transfusable platelets. Here, we describe a…”
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The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia by Thiel, Austin T, Feng, Zijie, Pant, Dhruv K, Chodosh, Lewis A, Hua, Xianxin

“…Trithorax and polycomb group proteins antagonistically regulate the transcription of many genes, and cancer can result from the disruption of this regulation…”
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Human embryonic stem cell-derived mesenchymal cells preserve kidney function and extend lifespan in NZB/W F1 mouse model of lupus nephritis by Thiel, Austin, Yavanian, Gregory, Nastke, Maria-Dorothea, Morales, Peter, Kouris, Nicholas A., Kimbrel, Erin A., Lanza, Robert

“…Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). However, the inability to…”
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Menin: a scaffold protein that controls gene expression and cell signaling by Matkar, Smita, Thiel, Austin, Hua, Xianxin

“…•Molecular and structural basis for menin-mediated activation of gene transcription.•Multiple modes and molecular basis of menin-mediated suppression of gene…”
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Abstract 4093: Investigating a role for menin and MLL-AF9 in suppressing C/EBPβ-mediated mixed lineage leukemia cell differentiation by Thiel, Austin T., Hua, Xianxin

“…Abstract The Mixed Lineage Leukemia (MLL) gene forms chromosomal translocations with one of multiple partner genes, leading to the expression of MLL fusion…”
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Menin Epigenetically Represses Hedgehog Signaling in MEN1 Tumor Syndrome by GURUNG, Buddha, ZIJIE FENG, IWAMOTO, Daniel V, THIEL, Austin, GUANGHUI JIN, FAN, Chen-Min, NG, Jessica M. Y, CURRAN, Tom, XIANXIN HUA

“…Multiple endocrine neoplasia type 1 (MEN1) is an inherited tumor syndrome that includes susceptibility to pancreatic islet tumors. This syndrome results from…”
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MLL-AF9-Induced Leukemogenesis Requires Co-Expression of the Wild Type Mll Allele by Thiel, Austin T., Blessington, Peter, Zou, Tao, Feather, Danielle, Wu, Xinjiang, Yan, Jizhou, Zhang, Hui, Liu, Zuguo, Ernst, Patricia, Koretzky, Gary A., Hua, Xianxin

“…Oncogenic fusion proteins are capable of initiating tumorigenesis but the role of their wild-type counterparts in this process is poorly understood. The mixed…”
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The central role of menin and wild-type MLL in MLL-AF9-induced leukemia by Thiel, Austin T

“…Chromosomal translocations involving the Mixed Lineage Leukemia ( MLL) gene lead to the expression of MLL fusion proteins and acute leukemia. MLL fusion…”
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