Search Results - "Thickett, David R"

Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease by Lugg, Sebastian T, Scott, Aaron, Parekh, Dhruv, Naidu, Babu, Thickett, David R

“…Cigarette smoking is the leading cause of preventable death worldwide. It causes chronic lung disease and predisposes individuals to acute lung injury and…”
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Long-term impact of developing a postoperative pulmonary complication after lung surgery by Lugg, Sebastian T, Agostini, Paula J, Tikka, Theofano, Kerr, Amy, Adams, Kerry, Bishay, Ehab, Kalkat, Maninder S, Steyn, Richard S, Rajesh, Pala B, Thickett, David R, Naidu, Babu

“…Postoperative pulmonary complications (PPC) such as atelectasis and pneumonia are common following lung resection. PPCs have a significant clinical impact on…”
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Predicting the pulmonary effects of long-term e-cigarette use: are the clouds clearing? by Davis, Lauren C, Sapey, Elizabeth, Thickett, David R, Scott, Aaron

“…Commercially available since 2007, e-cigarettes are a popular electronic delivery device of ever-growing complexity. Given their increasing use by ex-smokers,…”
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Sepsis Induces a Dysregulated Neutrophil Phenotype That Is Associated with Increased Mortality by Thickett, David R., Dosanjh, Davinder, Scott, Aaron, Parekh, Dhruv, Sapey, Elizabeth, Patel, Jaimin M., Smith, Fang Gao

“…Background. Neutrophil dysfunction in sepsis has been implicated in the pathogenesis of multiorgan failure; however, the role of neutrophil extracellular traps…”
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Wnt signaling regulates trans-differentiation of stem cell like type 2 alveolar epithelial cells to type 1 epithelial cells by Abdelwahab, Elhusseiny Mohamed Mahmud, Rapp, Judit, Feller, Diana, Csongei, Veronika, Pal, Szilard, Bartis, Domokos, Thickett, David R, Pongracz, Judit Erzsebet

“…Type 2 alveolar epithelial cells (AT2s) behave as stem cells and show clonal proliferation upon alveolar injury followed by trans-differentiation (TD) into…”
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Vitamin D to Prevent Lung Injury Following Esophagectomy—A Randomized, Placebo-Controlled Trial by Parekh, Dhruv, Dancer, Rachel C. A., Scott, Aaron, D’Souza, Vijay K., Howells, Phillip A., Mahida, Rahul Y., Tang, Jonathan C. Y., Cooper, Mark S., Fraser, William D., Tan, LamChin, Gao, Fang, Martineau, Adrian R., Tucker, Olga, Perkins, Gavin D., Thickett, David R.

“…OBJECTIVES:Observational studies suggest an association between vitamin D deficiency and adverse outcomes of critical illness and identify it as a potential…”
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Real-time assessment of neutrophil metabolism and oxidative burst using extracellular flux analysis by Grudzinska, Frances S, Jasper, Alice, Sapey, Elizabeth, Thickett, David R, Mauro, Claudio, Scott, Aaron, Barlow, Jonathan

“…Neutrophil responses are critical during inflammatory and infective events, and neutrophil dysregulation has been associated with poor patient outcomes…”
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Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers by Shyamsundar, Murali, McKeown, Scott T. W, O'Kane, Cecilia M, Craig, Thelma R, Brown, Vanessa, Thickett, David R, Matthay, Michael A, Taggart, Clifford C, Backman, Janne T, Elborn, J. Stuart, McAuley, Daniel F

“…Simvastatin inhibits inflammatory responses in vitro and in murine models of lung inflammation in vivo. As simvastatin modulates a number of the underlying…”
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Smoking and timing of cessation on postoperative pulmonary complications after curative-intent lung cancer surgery by Lugg, Sebastian T, Tikka, Theofano, Agostini, Paula J, Kerr, Amy, Adams, Kerry, Kalkat, Maninder S, Steyn, Richard S, Rajesh, Pala B, Bishay, Ehab, Thickett, David R, Naidu, Babu

“…Smoking is a risk factor for postoperative pulmonary complications (PPC) following non-small cell lung cancer (NSCLC) surgery. The optimal timing for…”
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Incidence and risk factors of acute kidney injury in COVID-19 patients with and without acute respiratory distress syndrome (ARDS) during the first wave of COVID-19: a systematic review and Meta-Analysis by Alenezi, Faraj K., Almeshari, Mohammed A., Mahida, Rahul, Bangash, Mansoor N., Thickett, David R., Patel, Jaimin M.

“…Acute kidney injury (AKI) is common among patients with COVID-19. However, AKI incidence may increase when COVID-19 patients develop acute respiratory distress…”
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Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS by Mahida, Rahul Y, Lax, Siân, Bassford, Christopher R, Scott, Aaron, Parekh, Dhruv, Hardy, Rowan S, Naidu, Babu, Matthay, Michael A, Stewart, Paul M, Cooper, Mark C, Perkins, Gavin D, Thickett, David R

“…Acute Respiratory Distress Syndrome (ARDS) is a devastating pulmonary inflammatory disorder, commonly precipitated by sepsis. Glucocorticoids are…”
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Real-world evaluation of rapid and laboratory-free COVID-19 triage for emergency care: external validation and pilot deployment of artificial intelligence driven screening by Soltan, Andrew A S, Yang, Jenny, Pattanshetty, Ravi, Novak, Alex, Yang, Yang, Rohanian, Omid, Beer, Sally, Soltan, Marina A, Thickett, David R, Fairhead, Rory, Zhu, Tingting, Eyre, David W, Clifton, David A, Watson, Adam, Bhargav, Akshay, Tough, Alex, Rogers, Alice, Shaikh, Ayisha, Valensise, Carolina, Lee, Charlotte, Otasowie, Claire, Metcalfe, David, Agarwal, Ekta, Zareh, Elham, Thangaraj, Evelyn, Pickles, Florence, Kelly, Gabriella, Tadikamalla, Gayatri, Shaw, George, Tong, Heather, Davies, Hettie, Bahra, Jasdeep, Morgan, Jessica, Wilson, Joe, Cutteridge, Joseph, O'Byrne, Katherine, Farache Trajano, Luiza, Oliver, Madeleine, Pikoula, Maria, Mendoza, Maya, Keevil, Melissa, Faisal, Muhammad, Dole, Natasha, Deal, Oscar, Conway-Jones, Rebecca, Sattar, Shajeel, Kundoor, Sneha, Shah, Sumaiyah, Muthusami, Vani

“…Uncertainty in patients' COVID-19 status contributes to treatment delays, nosocomial transmission, and operational pressures in hospitals. However, the typical…”
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Real-world retrospective observational study exploring the effectiveness and safety of antifibrotics in idiopathic pulmonary fibrosis by Wright, William Alexander, Crowley, Louise E, Parekh, Dhruv, Crawshaw, Anjali, Dosanjh, Davinder P, Nightingale, Peter, Thickett, David R

“…BackgroundPirfenidone and nintedanib are the only disease-modifying treatments available for idiopathic pulmonary fibrosis (IPF). Our aim was to test their…”
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Observational cohort study protocol: neutrophil function and energetics in adults with pneumonia and sepsis – Pneumonia Metabolism in Ageing (PUMA) by Grudzinska, Frances S, Faniyi, Aduragbemi A, Scott, Aaron, Sapey, Elizabeth, Thickett, David R

“…IntroductionCommunity-acquired pneumonia has high mortality and is associated with significant healthcare costs. In older adults with community-acquired…”
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Raised FGF23 Correlates to Increased Mortality in Critical Illness, Independent of Vitamin D by Thein, Onn Shaun, Ali, Naeman Akbar, Mahida, Rahul Y, Dancer, Rachel C A, Ostermann, Marlies, Amrein, Karin, Martucci, Gennaro, Scott, Aaron, Thickett, David R, Parekh, Dhruv

“…Fibroblast Growth Factor (FGF23) is an endocrine hormone classically associated with the homeostasis of vitamin D, phosphate, and calcium. Elevated serum FGF23…”
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CATALYST trial protocol: a multicentre, open-label, phase II, multiarm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults by Veenith, Tonny, Fisher, Benjamin A., Slade, Daniel, Rowe, Anna, Sharpe, Rowena, Thickett, David R., Whitehouse, Tony, Rowland, Matthew, Scriven, James, Parekh, Dhruv, Bowden, Sarah J., Savage, Joshua S., Richards, Duncan, Bion, Julian, Kearns, Pamela, Gates, Simon

“…IntroductionSevere SARS-CoV-2 infection is associated with a dysregulated immune response. Inflammatory monocytes and macrophages are crucial, promoting…”
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11β hydroxysteroid dehydrogenase type 1 transgenic mesenchymal stem cells attenuate inflammation in models of sepsis by Mahida, Rahul Y, Yuan, Zhengqiang, Kolluri, Krishna K, Scott, Aaron, Parekh, Dhruv, Hardy, Rowan S, Matthay, Michael A, Perkins, Gavin D, Janes, Sam M, Thickett, David R

“…Human bone marrow mesenchymal stem cell (MSC) administration reduces inflammation in pre-clinical models of sepsis and sepsis-related lung injury, however…”
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Dysregulated Neutrophil Phenotype and Function in Hospitalised Non-ICU COVID-19 Pneumonia by Belchamber, Kylie B R, Thein, Onn S, Hazeldine, Jon, Grudzinska, Frances S, Faniyi, Aduragbemi A, Hughes, Michael J, Jasper, Alice E, Yip, Kay Por, Crowley, Louise E, Lugg, Sebastian T, Sapey, Elizabeth, Parekh, Dhruv, Thickett, David R, Scott, Aaron

“…: Infection with the SARS-CoV2 virus is associated with elevated neutrophil counts. Evidence of neutrophil dysfunction in COVID-19 is based on transcriptomics…”
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COVID-19 admission risk tools should include multiethnic age structures, multimorbidity and deprivation metrics for air pollution, household overcrowding, housing quality and adult skills by Soltan, Marina A, Varney, Justin, Sutton, Benjamin, Melville, Colin R, Lugg, Sebastian T, Parekh, Dhruv, Carroll, Will, Dosanjh, Davinder P, Thickett, David R

“…BackgroundEthnic minorities account for 34% of critically ill patients with COVID-19 despite constituting 14% of the UK population. Internationally,…”
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Down-regulation of canonical and up-regulation of non-canonical Wnt signalling in the carcinogenic process of squamous cell lung carcinoma by Bartis, Domokos, Csongei, Veronika, Weich, Alexander, Kiss, Edit, Barko, Szilvia, Kovacs, Tamas, Avdicevic, Monika, D'Souza, Vijay K, Rapp, Judit, Kvell, Krisztian, Jakab, Laszlo, Nyitrai, Miklos, Molnar, Tamas F, Thickett, David R, Laszlo, Terezia, Pongracz, Judit E

“…The majority of lung cancers (LC) belong to the non-small cell lung carcinoma (NSCLC) type. The two main NSCLC sub-types, namely adenocarcinoma (AC) and…”
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