Search Results - "Thewke, Douglas"

Conformationally Altered C-Reactive Protein Capable of Binding to Atherogenic Lipoproteins Reduces Atherosclerosis by Pathak, Asmita, Singh, Sanjay K, Thewke, Douglas P, Agrawal, Alok

“…The aim of this study was to test the hypothesis that C-reactive protein (CRP) protects against the development of atherosclerosis and that a conformational…”
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Deficiency of ataxia‐telangiectasia mutated kinase attenuates Western‐type diet‐induced cardiac dysfunction in female mice by Wingard, Mary C., Dalal, Suman, Shook, Paige L., Ramirez, Paulina, Raza, Muhammad U., Johnson, Patrick, Connelly, Barbara A., Thewke, Douglas P., Singh, Mahipal, Singh, Krishna

“…Chronic consumption of Western‐type diet (WD) induces cardiac structural and functional abnormalities. Previously, we have shown that WD consumption in male…”
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Deficiency of ataxia-telangiectasia mutated kinase modulates functional and biochemical parameters of the heart in response to Western-type diet by Wingard, Mary C, Dalal, Suman, Shook, Paige L, Myers, Rachel, Connelly, Barbara A, Thewke, Douglas P, Singh, Mahipal, Singh, Krishna

“…Ataxia-telangiectasia mutated (ATM) kinase deficiency exacerbates heart dysfunction late after myocardial infarction. Here, we hypothesized that ATM deficiency…”
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Cannabinoid receptor type 2 (CB2) deficiency alters atherosclerotic lesion formation in hyperlipidemic Ldlr-null mice by Netherland, Courtney D, Pickle, Theresa G, Bales, Alicia, Thewke, Douglas P

“…Abstract Objective To determine if cannabinoid receptor 2 (CB2) plays a role in atherosclerosis, we investigated the effects of systemic CB2 gene deletion on…”
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Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24 by Corrigan, Douglas P, Kuszczak, Danuta, Rusinol, Antonio E, Thewke, Douglas P, Hrycyna, Christine A, Michaelis, Susan, Sinensky, Michael S

“…The nuclear lamins form a karyoskeleton providing structural rigidity to the nucleus. One member of the lamin family, lamin A, is first synthesized as a 74 kDa…”
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Rimonabant is a dual inhibitor of acyl CoA:cholesterol acyltransferases 1 and 2 by Netherland, Courtney, Thewke, Douglas P.

“…► Rimonabant reduces cholesteryl ester synthesis in macrophages. ► Rimonabant inhibits acyl CoA:cholesterol acyltransferase 1 and 2 in intact cells. ►…”
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Reduced Macrophage Apoptosis Is Associated With Accelerated Atherosclerosis in Low-Density Lipoprotein Receptor–Null Mice by Liu, June, Thewke, Douglas P, Su, Yan Ru, Linton, MacRae F, Fazio, Sergio, Sinensky, Michael S

“…OBJECTIVE—The majority of apoptotic cells in atherosclerotic lesions are macrophages. However, the pathogenic role of macrophage apoptosis in the development…”
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Wnt2 Contributes to the Development of Atherosclerosis by Zhang, Jinyu, Rojas, Samuel, Singh, Sanjay, Musich, Phillip R, Gutierrez, Matthew, Yao, Zhiqiang, Thewke, Douglas, Jiang, Yong

“…Atherosclerosis, is a chronic inflammatory disease, characterized by the narrowing of the arteries resulting from the formation of intimal plaques in the wall…”
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The Contribution of Endothelial-Mesenchymal Transition to Atherosclerosis by Zhang, Jinyu, Ogbu, Stella C., Musich, Phillip R., Thewke, Douglas P., Yao, Zhiqiang, Jiang, Yong

“…Atherosclerosis is a chronic progressive condition in which the wall of the artery develops abnormalities and causes thickening of the blood vessels. The…”
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KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells by Chang, Yongsheng, Wang, Jieru, Lu, Xiaojun, Thewke, Douglas P, Mason, Robert J

“…Lipid synthesis is required for cell growth and is subject to pharmacologic regulation. Keratinocyte growth factor (KGF) stimulates proliferation and…”
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Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis by Freeman-Anderson, Natalie E., Pickle, Theresa G., Netherland, Courtney D., Bales, Alicia, Buckley, Nancy E., Thewke, Douglas P.

“…Macrophage apoptosis is an important process in the pathophysiology of atherosclerosis. Oxidized low-density lipoproteins (OxLDL) are a major component of…”
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Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol by Liu, June, Netherland, Courtney, Pickle, Theresa, Sinensky, Michael S., Thewke, Douglas P.

“…Akt plays a role in protecting macrophages from apoptosis induced by some oxysterols. Previously we observed enhanced degradation of Akt in P388D1…”
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AKT/Protein Kinase B Regulation of BCL Family Members during Oxysterol-induced Apoptosis by Rusiñol, Antonio E., Thewke, Douglas, Liu, June, Freeman, Natalie, Panini, Sankhavaram R., Sinensky, Michael S.

“…Cells of the vasculature, including macrophages, smooth muscle cells, and endothelial cells, exhibit apoptosis in culture upon treatment with oxidized low…”
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Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages by Freeman, Natalie E, Rusinol, Antonio E, Linton, MacRae, Hachey, David L, Fazio, Sergio, Sinensky, Michael S, Thewke, Douglas

“…7-Ketocholesterol (7KC) is a cytotoxic component of oxidized low density lipoproteins (OxLDLs) and induces apoptosis in macrophages by a mechanism involving…”
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Isolation of a Somatic Cell Mutant Resistant to the Induction of Apoptosis by Oxidized Low Density Lipoprotein by Rusiñol, Antonio E., Yang, Lin, Thewke, Douglas, Panini, Sankhavaram R., Kramer, Marianne F., Sinensky, Michael S.

“…Oxidized low density lipoprotein (oxLDL) induces apoptosis in macrophages, smooth muscle cells, and endothelial cells. To elucidate the molecular mechanism of…”
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Expression of Hepatocyte Growth Factor/Scatter Factor, Its Receptor, c-met, and Tissue-Type Plasminogen Activator during Development of the Murine Olfactory System by Thewke, Douglas P, Seeds, Nicholas W

“…The expression of hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the c-met proto-oncogene product, was examined by in situ hybridization in…”
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Oleate Potentiates Oxysterol Inhibition of Transcription from Sterol Regulatory Element-1-regulated Promoters and Maturation of Sterol Regulatory Element-binding Proteins by Thewke, Douglas P., Panini, Sankhavaram R., Sinensky, Michael

“…Activation of genes containing SRE-1 (sterol regulatory element1) sequences is known to be under the regulation of sterols through modulation of the…”
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Abstract 643: Type-2 Cannabinoid Receptor Deficiency is Associated with Atherosclerotic Lesion Calcification in Ldlr-null Mice by Fulmer, Makenzie L, Englehaupt, Emilee, Garst, Chris, Brown, Stacy, Thewke, Douglas

“…Abstract only Background: Calcification of atherosclerotic plaques is associated with vulnerability to rupture and increased risk of myocardial infarction. The…”
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AM-251 and SR144528 are acyl CoA:cholesterol acyltransferase inhibitors by Thewke, Douglas, Freeman-Anderson, Natalie, Pickle, Theresa, Netherland, Courtney, Chilton, Courtney

“…Oxysterol-induced macrophage apoptosis may have a role in atherosclerosis. Macrophages lacking the type 2 cannabinoid receptor (CB2) are partially resistant to…”
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The expression of mRNAs for hepatocyte growth factor/scatter factor, its receptor c- met, and one of its activators tissue-type plasminogen activator show a systematic relationship in the developing and adult cerebral cortex and hippocampus by Thewke, Douglas P., Seeds, Nicholas W.

“…The temporal and spatial expression in brain of the mRNAs for the pleiotropic cytokine hepatocyte growth factor/scatter factor (HGF/SF) and its receptor c- met…”
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