Search Results - "Thewalt, J."

Ionizable amino lipid interactions with POPC: implications for lipid nanoparticle function by Ramezanpour, M, Schmidt, M L, Bodnariuc, I, Kulkarni, J A, Leung, S S W, Cullis, P R, Thewalt, J L, Tieleman, D P

“…Lipid nanoparticles (LNPs) composed of ionizable cationic lipids are currently the leading systems for siRNA delivery in liver disease, with the major…”
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Computational and experimental approaches for investigating nanoparticle-based drug delivery systems by Ramezanpour, M., Leung, S.S.W., Delgado-Magnero, K.H., Bashe, B.Y.M., Thewalt, J., Tieleman, D.P.

“…Most therapeutic agents suffer from poor solubility, rapid clearance from the blood stream, a lack of targeting, and often poor translocation ability across…”
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Structural Properties of Inverted Hexagonal Phase: A Hybrid Computational and Experimental Approach by Ramezanpour, M, Schmidt, M. L, Bashe, B. Y. M, Pruim, J. R, Link, M. L, Cullis, P. R, Harper, P. E, Thewalt, J. L, Tieleman, D. P

“…Inverted/reverse hexagonal (HII) phases are of special interest in several fields of research, including nanomedicine. We used molecular dynamics (MD)…”
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Universal Behavior of Membranes with Sterols by Henriksen, J., Rowat, A.C., Brief, E., Hsueh, Y.W., Thewalt, J.L., Zuckermann, M.J., Ipsen, J.H.

“…Lanosterol is the biosynthetic precursor of cholesterol and ergosterol, sterols that predominate in the membranes of mammals and lower eukaryotes,…”
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Phosphatidylcholine : cholesterol phase diagrams by THEWALT, J. L, BLOOM, M

“…Two mono-cis-unsaturated phosphatidylcholine (PC) lipid molecules, having very different gel-liquid crystalline phase transition temperatures as a consequence…”
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Models of stratum corneum intercellular membranes: 2H NMR of macroscopically oriented multilayers by Fenske, D.B., Thewalt, J.L., Bloom, M., Kitson, N.

“…Deuterium NMR was used to characterize model membrane systems approximating the composition of the intercellular lipid lamellae of mammalian stratum corneum…”
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A Model Membrane Approach to the Epidermal Permeability Barrier:  An X-ray Diffraction Study by Bouwstra, J. A, Thewalt, J, Gooris, G. S, Kitson, N

“…The permeability of mammalian skin is determined in large part by lamellar lipid domains packed between cells of the upper layer of the epidermis, the stratum…”
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Hypothesis: the epidermal permeability barrier is a porous medium by Kitson, N, Thewalt, J L

“…The stratum corneum is a complex biological material characterized by very low permeability to water and most other molecules. This material may be thought of…”
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Hypothesis: The epidermal permeability barrier is a porous medium by Kitson, Neil, Thewalt, Jenifer L.

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The Effect of Ergosterol on Dipalmitoylphosphatidylcholine Bilayers: A Deuterium NMR and Calorimetric Study by Hsueh, Ya-Wei, Gilbert, Kyle, Trandum, C., Zuckermann, M., Thewalt, Jenifer

“…We have studied the effect of ergosterol, an important component of fungal plasma membranes, on the physical properties of dipalmitoylphosphatidylcholine…”
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Deuterium NMR study of the interaction of .alpha.-tocopherol with a phospholipid model membrane by Wassall, Stephen R, Thewalt, Jenifer L, Wong, Linda, Gorrissen, Heiner, Cushley, Robert J

“…The effects of 5, 10, and 20 mol % incorporation of alpha-tocopherol (vitamin E) on 50 wt % aqueous multilamellar dispersions of sn-2-substituted…”
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Time and distance scales of membrane domain organization by Bloom, M, Thewalt, J L

“…Time and distance scales in membranes are discussed in relation to the inference of domain structure from spectroscopic measurements. Each type of spectroscopy…”
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From Lanosterol to Cholesterol: Structural Evolution and Differential Effects on Lipid Bilayers by Miao, Ling, Nielsen, Morten, Thewalt, Jenifer, Ipsen, John H., Bloom, Myer, Zuckermann, Martin J., Mouritsen, Ole G.

“…Cholesterol is an important molecular component of the plasma membranes of mammalian cells. Its precursor in the sterol biosynthetic pathway, lanosterol, has…”
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The Effect of Ceramide on Phosphatidylcholine Membranes: A Deuterium NMR Study by Hsueh, Ya-Wei, Giles, Ralph, Kitson, Neil, Thewalt, Jenifer

“…Biological membranes contain domains having distinct physical properties. We study defined mixtures of phosphoglycerolipids and sphingolipids to ascertain the…”
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Deuterium nuclear magnetic resonance study of the interaction of branched chain compounds (phytanic acid, phytol) with a phospholipid model membrane by Yue, J, Thewalt, J L, Cushley, R J

“…Deuterium nuclear magnetic resonance (2H-NMR) spectra have been determined for 50 wt% aqueous dispersions of…”
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A deuterium NMR study of labelled n-alkanol anesthetics in a model membrane by Thewalt, J L, Tulloch, A P, Cushley, R J

“…The 2H-NMR spectra of 50 wt.% aqueous multilamellar dispersions of dipalmitoylphosphatidylcholine (DPPC) containing either selectively deuterated 1-decanol (25…”
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A Model Membrane Approach to the Epidermal Permeability Barrier by Kitson, Neil, Thewalt, Jenifer, Lafleur, Michel, Bloom, Myer

“…The permeability barrier of mammalian skin is found in unusual intercellular domains in the upper layers of the epidermis, and is composed mainly of three…”
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Phospholipid/cholesterol membranes containing n-alkanols: a 2H-NMR study by Thewalt, J L, Cushley, R J

“…The influences of 1-octanol and 1-decanol on aqueous multilamellar dispersions of 1-hexadecanoyl(octadecanoyl)-2-[2H31]hexadecanoyl-sn-glycero…”
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Modeling lipid-sterol bilayers: applications to structural evolution, lateral diffusion, and rafts by Zuckermann, Martin J, Ipsen, John H, Miao, Ling, Mouritsen, Ole G, Nielsen, Morten, Polson, James, Thewalt, Jenifer, Vattulainen, Ilpo, Zhu, Hong

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Deuterium NMR study of the effect of n-alkanol anesthetics on a model membrane system by Thewalt, J L, Wassall, S R, Gorrissen, H, Cushley, R J

“…The effects of 25 mol% incorporation of two anesthetics, 1-octanol and 1-decanol, on a deuterated, saturated phospholipid in 50 wt% aqueous multilamellar…”
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