Search Results - "Thevananther, Sundararajah"

Endothelial nitric oxide synthase is a key mediator of hepatocyte proliferation in response to partial hepatectomy in mice by Mei, Yu, Thevananther, Sundararajah

“…Endothelial nitric oxide synthase (eNOS) is a critical modulator of vascular tone and blood flow and plays major roles in liver physiology and pathophysiology…”
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TGR5 activation induces cytoprotective changes in the heart and improves myocardial adaptability to physiologic, inotropic, and pressure-induced stress in mice by Eblimit, Zeena, Thevananther, Sundararajah, Karpen, Saul J, Taegtmeyer, Heinrich, Moore, David D, Adorini, Luciano, Penny, Daniel J, Desai, Moreshwar S

“…Administration of cholic acid, or its synthetic derivative, 6-alpha-ethyl-23(S)-methylcholic acid (INT-777), activates the membrane GPCR, TGR5, influences…”
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Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis by Desai, Moreshwar S., Shabier, Zainuer, Taylor, Michael, Lam, Fong, Thevananther, Sundararajah, Kosters, Astrid, Karpen, Saul J.

“…Cardiac dysfunction is a major cause of morbidity and mortality in patients with end‐stage liver disease; yet the mechanisms remain largely unknown. We…”
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ATP release after partial hepatectomy regulates liver regeneration in the rat by Gonzales, Emmanuel, Julien, Boris, Serrière-Lanneau, Valérie, Nicou, Alexandra, Doignon, Isabelle, Lagoudakis, Laura, Garcin, Isabelle, Azoulay, Daniel, Duclos-Vallée, Jean-Charles, Castaing, Denis, Samuel, Didier, Hernandez-Garcia, Andres, Awad, Samir S, Combettes, Laurent, Thevananther, Sundararajah, Tordjmann, Thierry

“…Background & Aims Paracrine interactions are critical to liver physiology, particularly during regeneration, although physiological involvement of…”
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Redundant Pathways for Negative Feedback Regulation of Bile Acid Production by Wang, Li, Lee, Yoon-Kwang, Bundman, Donnie, Han, Yunqing, Thevananther, Sundararajah, Kim, Chang-Soo, Chua, Steven S, Wei, Ping, Heyman, Richard A, Karin, Michael, Moore, David D

“…The orphan nuclear hormone receptor SHP has been proposed to have a key role in the negative feedback regulation of bile acid production. Consistent with this,…”
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Comparative analyses of lung transcriptomes in patients with alveolar capillary dysplasia with misalignment of pulmonary veins and in foxf1 heterozygous knockout mice by Sen, Partha, Dharmadhikari, Avinash V, Majewski, Tadeusz, Mohammad, Mahmoud A, Kalin, Tanya V, Zabielska, Joanna, Ren, Xiaomeng, Bray, Molly, Brown, Hannah M, Welty, Stephen, Thevananther, Sundararajah, Langston, Claire, Szafranski, Przemyslaw, Justice, Monica J, Kalinichenko, Vladimir V, Gambin, Anna, Belmont, John, Stankiewicz, Pawel

“…Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins (ACDMPV) is a developmental disorder of the lungs, primarily affecting their vasculature…”
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SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis by Fleet, Tiffany, Zhang, Bin, Lin, Fumin, Zhu, Bokai, Dasgupta, Subhamoy, Stashi, Erin, Tackett, Bryan, Thevananther, Sundararajah, Rajapakshe, Kimal I., Gonzales, Naomi, Dean, Adam, Mao, Jianqiang, Timchenko, Nikolai, Malovannaya, Anna, Qin, Jun, Coarfa, Cristian, DeMayo, Francesco, Dacso, Clifford C., Foulds, Charles E., O’Malley, Bert W., York, Brian

“…Despite extensive efforts to understand the monogenic contributions to perturbed glucose homeostasis, the complexity of genetic events that fractionally…”
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Evaluation of Asymmetric Liposomal Nanoparticles for Encapsulation of Polynucleotides by Whittenton, Jeremiah, Harendra, Sivaram, Pitchumani, Ramanan, Mohanty, Kishore, Vipulanandan, Cumaraswamy, Thevananther, Sundararajah

“…Conventional lipid bilayer liposomes have similar inner and outer leaflet compositions; asymmetric liposomes have different lipid leaflet compositions. The…”
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Partial ATP depletion induces Fas- and caspase-mediated apoptosis in MDCK cells by Feldenberg, L R, Thevananther, S, del Rio, M, de Leon, M, Devarajan, P

“…Brief periods of in vitro hypoxia/ischemia induce apoptosis of cultured renal epithelial cells, but the underlying mechanisms remain unknown. We show that…”
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Adipose to the rescue: Peripheral fat fuels liver regeneration by Thevananther, Sundararajah

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321 – P2X2 Purinergic Receptor Signaling Promotes Hepatocellular Injury in Non-Alcoholic Steatohepatitis by Perez, Carla, Dodd, Nicholas, Narayanan, Subapradha, Thevananther, Sundararajah

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Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits by Xu, G, Shneider, B L, Shefer, S, Nguyen, L B, Batta, A K, Tint, G S, Arrese, M, Thevananther, S, Ma, L, Stengelin, S, Kramer, W, Greenblatt, D, Pcolinsky, M, Salen, G

“…We investigated the effect of ileal bile acid transport on the regulation of classic and alternative bile acid synthesis in cholesterol-fed rats and rabbits…”
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Constitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer by Shneider, Benjamin L, Cortes-Santiago, Nahir, Schady, Deborah A, Krishnamoorthy, Swapna, Thevananther, Sundararajah, Rajapakshe, Kimal, Perera, Dimuthu, Huang, Shixia, Coarfa, Cristian

“…Activation of mitogen-activated protein kinases (MAPKs) is a key factor in the pathogenesis of cancer, although the specific role of mitogen-activated protein…”
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P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality by Arunachalam, Athis R, Samuel, Sanju S, Mani, Arunmani, Maynard, Janielle P, Stayer, Kelsey M, Dybbro, Eric, Narayanan, Subapradha, Biswas, Aalekhya, Pathan, Saliha, Soni, Krishnakant, Kamal, Abu Hena Mostafa, Ambati, Chandra Shekar R, Putluri, Nagireddy, Desai, Moreshwar S, Thevananther, Sundararajah

“…The liver plays a significant role in regulating a wide range of metabolic, homeostatic, and host-defense functions. However, the impact of liver injury on the…”
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Delayed liver regeneration after partial hepatectomy in adipose differentiation related protein-null mice by Kohjima, Motoyuki, Tsai, Tsung-Huang, Tackett, Bryan C, Thevananther, Sundararajah, Li, Lan, Chang, Benny Hung-Junn, Chan, Lawrence

“…Background & Aims Adult hepatocytes undergo cell cycle progression and proliferation in response to partial hepatectomy (PH). Transient lipid accumulation…”
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P2Y2 purinergic receptor activation is essential for efficient hepatocyte proliferation in response to partial hepatectomy by Tackett, Bryan C, Sun, Hongdan, Mei, Yu, Maynard, Janielle P, Cheruvu, Sayuri, Mani, Arunmani, Hernandez-Garcia, Andres, Vigneswaran, Nadarajah, Karpen, Saul J, Thevananther, Sundararajah

“…Extracellular nucleotides via activation of P2 purinergic receptors influence hepatocyte proliferation and liver regeneration in response to 70% partial…”
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Cloning and Characterization of a Novel Peptidase from Rat and Human Ileum by Shneider, Benjamin L., Thevananther, Sundararajah, Moyer, M. Susan, Walters, Holly C., Rinaldo, Piero, Devarajan, Prasad, Sun, An Qiang, Dawson, Paul A., Ananthanarayanan, Meenakshisundaram

“…A novel 100-kDa ileal brush border membrane protein (I100) has been purified by anionic glycocholate affinity chromatography. Polyclonal antibodies raised…”
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Tu1273 - Expression of Constitutively Active Mitogen-Activated Protein Kinase 1 (MEK1) Profoundly Disrupts Ileal Epithelial Homeostasis by Shneider, Benjamin L., Krishnamoorthy, Swapna, Schady, Deborah, Cortes-Santiago, Nahir, Thevananther, Sundararajah, Huang, Shixia, Rajapakshe, Kimal, Coarfa, Cristian, Edwards, Dean, Shroyer, Noah F., Finegold, Milton J.

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P2X3 purinergic receptor overexpression is associated with poor recurrence-free survival in hepatocellular carcinoma patients by Maynard, Janielle P, Lee, Ju-Seog, Sohn, Bo Hwa, Yu, Xiaoying, Lopez-Terrada, Dolores, Finegold, Milton J, Goss, John A, Thevananther, Sundararajah

“…P2 purinergic receptors are overexpressed in certain cancer tissues, but the pathophysiologic relevance of purinergic signaling in hepatocellular carcinoma…”
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Cardiomyopathy reverses with recovery of liver injury, cholestasis and cholanemia in mouse model of biliary fibrosis by Desai, Moreshwar S., Eblimit, Zeena, Thevananther, Sundararajah, Kosters, Astrid, Moore, David D., Penny, Daniel J., Karpen, Saul J.

“…Background Triggers and exacerbants of cirrhotic cardiomyopathy (CC) are poorly understood, limiting treatment options in patients with chronic liver diseases…”
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