Biological Monitoring of Polycyclic Aromatic Hydrocarbons Metabolites in Urine

Biological Monitoring of Polycyclic Aromatic Hydrocarbons Metabolites in Urine

Assays of urinary mutagenicity, urinary 3-hydroxy-benzo(a)pyrene, and urinary 1-hydroxypyrene were used to study their suitability in estimating exposure to polycyclic aromatic hydrocarbons (PAH) in coal tar products. Rats exposed to coal tar solutions applied on the dorsal skin excreted mutagens, 3...

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Bibliographic Details
Published in:Scandinavian Journal of Work, Environment ＆ Health Vol. 12; no. 2; pp. 137 - 143
Main Authors: Jongeneelen, Frans J, Bos, Robert P, Anzion, Rob BM, Theuws, Jack LG, Henderson, Peter T
Format: Journal Article
Language:English
Published: Finland Scandinavian Journal of Work, Environment ＆ Health 01-04-1986
National Board of Occupational Safety and Health
The Working Environment Fund
Swedish Medical Society, Section for Environmental Health
Work Research Institutes
Institute of Occupational Health
Subjects:
Adult
Animals
Benzopyrenes - urine
Cigar smoking
Cigarette smoking
Cigarettes
Coal tar
Coal Tar - pharmacology
Coal Tar - therapeutic use
Coal Tar - urine
Eczema - drug therapy
Environmental Exposure
Environmental Monitoring
Excretion
Humans
Male
Metabolites
Mutagenicity
Mutagens
Mutagens - urine
Pyrenes - urine
Rats
Rats, Inbred Strains
Referents
Skin - drug effects
Smoking
Urine
Netherlands
mutagens
dermatologic patients
coal tar
benzo a pyrene
workers
pyrene
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Summary:Assays of urinary mutagenicity, urinary 3-hydroxy-benzo(a)pyrene, and urinary 1-hydroxypyrene were used to study their suitability in estimating exposure to polycyclic aromatic hydrocarbons (PAH) in coal tar products. Rats exposed to coal tar solutions applied on the dorsal skin excreted mutagens, 3-hydroxy-benzo(a)pyrene, and 1-hydroxypyrene dose dependently in their urine. The correlation between the three parameters was high. Five dermatologie patients undergoing topical coal tar treatment excreted low concentrations of 3-hydroxy-benzo(a)pyrene and high concentrations of 1-hydroxypyrene. A significant correlation between the excretion of the two metabolites was found. The smoking workers of a coal tar distillation plant showed a significantly enhanced urinary mutagenicity compared with their nonsmoking colleagues, but an increase due to occupational exposure was not found. However, the concentration of 1-hydroxypyrene in the urine of these workers highly exceeded the upper 95 percentile of a reference population. The urinary excretion of 1-hydroxypyrene of smoking referents was not significantly increased compared with that of nonsmoking referents. The data suggest that urinary 1-hydroxypyrene is a sensitive and specific marker for the assessment of occupational exposure to PAH.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0355-3140
1795-990X
DOI:10.5271/sjweh.2166