Search Results - "Theunissen, E. L"

Ayahuasca enhances creative divergent thinking while decreasing conventional convergent thinking by Kuypers, K. P. C., Riba, J., de la Fuente Revenga, M., Barker, S., Theunissen, E. L., Ramaekers, J. G.

“…Introduction Ayahuasca is a South American psychotropic plant tea traditionally used in Amazonian shamanism. The tea contains the psychedelic 5-HT 2A receptor…”
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A pooled analysis of on-the-road highway driving studies in actual traffic measuring standard deviation of lateral position (i.e., “weaving”) while driving at a blood alcohol concentration of 0.5 g/L by Jongen, S., Vermeeren, A., van der Sluiszen, N. N. J. J. M., Schumacher, M. B., Theunissen, E. L., Kuypers, K. P. C., Vuurman, E. F. P. M., Ramaekers, J. G.

“…Introduction The on-the-road highway driving test is generally regarded as a gold standard for assessing drug-induced driving impairment. The primary outcome…”
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Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users by Ramaekers, JG, Kauert, G, Theunissen, EL, Toennes, SW, Moeller, MR

“…Abstract Performance impairment during Δ9-tetrahydrocannabinol (THC) intoxication has been well described in occasional cannabis users. It is less clear…”
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Subjective aggression during alcohol and cannabis intoxication before and after aggression exposure by De Sousa Fernandes Perna, E. B., Theunissen, E. L., Kuypers, K. P. C., Toennes, S. W., Ramaekers, J. G.

“…Rationale Alcohol and cannabis use have been implicated in aggression. Alcohol consumption is known to facilitate aggression, whereas a causal link between…”
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Functional brain connectomes reflect acute and chronic cannabis use by Ramaekers, J. G., Mason, N. L., Toennes, S. W., Theunissen, E. L., Amico, E.

“…Resting state fMRI has been employed to identify alterations in functional connectivity within or between brain regions following acute and chronic exposure to…”
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Cannabis containing equivalent concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) induces less state anxiety than THC-dominant cannabis by Hutten, Nadia R. P. W., Arkell, T. R., Vinckenbosch, F., Schepers, J., Kevin, R. C., Theunissen, E. L., Kuypers, K. P. C., McGregor, I. S., Ramaekers, J. G.

“…Rationale Delta -9-tetrahydrocannabinol (THC), an active component of cannabis, can cause anxiety in some users during intoxication. Cannabidiol (CBD), another…”
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A Randomized Trial on the Acute and Steady-State Effects of a New Antidepressant, Vortioxetine (Lu AA21004), on Actual Driving and Cognition by Theunissen, E L, Street, D, Højer, A-M, Vermeeren, A, van Oers, A, Ramaekers, J G

“…The aim of this study was to assess the effects of a novel antidepressant, vortioxetine 10 mg, on driving, cognitive, and psychomotor performance in 24 healthy…”
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A placebo-controlled study to assess Standardized Field Sobriety Tests performance during alcohol and cannabis intoxication in heavy cannabis users and accuracy of point of collection testing devices for detecting THC in oral fluid by Bosker, W. M., Theunissen, E. L., Conen, S., Kuypers, K. P. C., Jeffery, W. K., Walls, H. C., Kauert, G. F., Toennes, S. W., Moeller, M. R., Ramaekers, J. G.

“…Rationale Standardized Field Sobriety Tests (SFST) and oral fluid devices are used to screen for driving impairment and roadside drug detection, respectively…”
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Drug liking and wanting, not impulsive action or reflection is increased by 4-fluoroamphetamine by Kuypers, K. P. C., de Sousa Fernandes Perna, E. B., Dolder, P. C., Toennes, S. W., Theunissen, E. L., Mason, N. L., Hutten, N. R. P. W., Ramaekers, J. G.

“…Background New psychoactive substances (NPS) are chemical analogues designed to mimic the effects of various classic recreational drugs of abuse including…”
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On-the-road driving performance after use of the antihistamines mequitazine and l-mequitazine, alone and with alcohol by van der Sluiszen, N. N. J. J. M., Vermeeren, A., Jongen, S., Theunissen, E. L., van Oers, A. C. M., Van Leeuwen, C. J., Maret, A., Desforges, C., Delarue, A., Ramaekers, J. G.

“…Objective Previous studies demonstrated that mequitazine produces mild sedation after single doses. Its enantiomer, l-mequitazine, has a stronger potency for…”
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Depressive mood ratings are reduced by MDMA in female polydrug ecstasy users homozygous for the l-allele of the serotonin transporter by Kuypers, K. P. C., de la Torre, R., Farre, M., Xicota, L., de Sousa Fernandes Perna, E. B., Theunissen, E. L., Ramaekers, J. G.

“…MDMA exerts its main effects via the serotonergic system and the serotonin transporter. The gene coding for this transporter determines the expression rate of…”
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Methylphenidate reduces functional connectivity of nucleus accumbens in brain reward circuit by Ramaekers, J. G., Evers, E. A., Theunissen, E. L., Kuypers, K. P. C., Goulas, A., Stiers, P.

“…Release of dopamine in the nucleus accumbens (NAcc) is essential for acute drug reward. The present study was designed to trace the reinforcing effect of…”
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A First-in-Man Study with 4-Fluoroamphetamine Demonstrates it Produces a Mild Psychedelic State by Kuypers, K. P. C., De Sousa Fernandes Perna, E. B., Theunissen, E. L, Toennes, S. W., Mason, N. L., Hutten, N. R. P. W., Ramaekers, J. G.

“…The phenethylamine 4-fluoroamphetamine (4-FA) is a so-called novel psychoactive substance with a chemical structure resembling that of amphetamine and MDMA…”
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Blockade of 5-HT2 Receptor Selectively Prevents MDMA-Induced Verbal Memory Impairment by VAN WEL, Jhp, KUYPERS, Kpc, THEUNISSEN, E. L, BOSKER, W. M, BAKKER, K, RAMAEKERS, J. G

“…3,4-Methylenedioxymethamphetamine (MDMA) or 'ecstasy' has been associated with memory deficits during abstinence and intoxication. The human neuropharmacology…”
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Cannabis and cocaine decrease cognitive impulse control and functional corticostriatal connectivity in drug users with low activity DBH genotypes by Ramaekers, J. G., van Wel, J. H., Spronk, D., Franke, B., Kenis, G., Toennes, S. W., Kuypers, K. P. C., Theunissen, E. L., Stiers, P., Verkes, R. J.

“…The dopamine β-hydroxylase (DβH) enzyme transforms dopamine into noradrenaline. We hypothesized that individuals with low activity DBH genotypes (rs1611115…”
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Neurocognitive performance following acute mephedrone administration, with and without alcohol by de Sousa Fernandes Perna, EB, Papaseit, E, Pérez-Mañá, C, Mateus, J, Theunissen, EL, Kuypers, KPC, de la Torre, R, Farré, M, Ramaekers, JG

“…Recreational use of mephedrone, alone and in combination with alcohol, has increased over the past years. Pharmacological properties of mephedrone share…”
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Rivastigmine but not vardenafil reverses cannabis-induced impairment of verbal memory in healthy humans by Theunissen, E. L., Heckman, P., de Sousa Fernandes Perna, E. B., Kuypers, K. P. C., Sambeth, A., Blokland, A., Prickaerts, J., Toennes, S. W., Ramaekers, J. G.

“…Rationale One of the most often reported cognitive deficits of acute cannabis administration is an impaired recall of previously learned information. Objective…”
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Psychedelic symptoms of cannabis and cocaine use as a function of trait impulsivity by van Wel, JHP, Spronk, DB, Kuypers, KPC, Theunissen, EL, Toennes, SW, Verkes, RJ, Ramaekers, JG

“…Trait impulsivity has been linked to addiction in humans. It has been suggested that drug users with high trait impulsivity levels are more sensitive to…”
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Blunted highs: Pharmacodynamic and behavioral models of cannabis tolerance by Ramaekers, J.G., Mason, N.L., Theunissen, E.L.

“…Acute exposure to cannabis comes with neurocognitive impairment, leading to increased risk of human error and injury. Evidence however indicates that such…”
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A dose-ranging study of the effects of mequitazine on actual driving, memory and psychomotor performance as compared to dexchlorpheniramine, cetirizine and placebo by Theunissen, E. L., Vermeeren, A., Van Oers, A. C. M., Van Maris, I., Ramaekers, J. G.

“…Summary Background Mequitazine is a so‐called ‘non‐sedative’ second‐generation antihistamine even though it has never been firmly established that this drug's…”
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