Search Results - "These, Anja"
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In vitro biotransformation of pyrrolizidine alkaloids in different species: part II—identification and quantitative assessment of the metabolite profile of six structurally different pyrrolizidine alkaloids
Published in Archives of toxicology (01-11-2020)“…Pyrrolizidine alkaloids (PA) exert their toxic effects only after bioactivation. Although their toxicity has already been studied and metabolic pathways…”
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Occurrence of pyrrolizidine alkaloids in animal- and plant-derived food: results of a survey across Europe
Published in Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment (01-01-2018)“…Pyrrolizidine alkaloids (PAs) are secondary metabolites of plant families such as Asteraceae or Boraginaceae and are suspected to be genotoxic carcinogens…”
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3
Metabolic Pattern of Hepatotoxic Pyrrolizidine Alkaloids in Liver Cells
Published in Chemical research in toxicology (19-04-2021)“…Contamination with 1,2-unsaturated pyrrolizidine alkaloids (PAs) is a serious problem for certain phytomedicines, foods, and animal feeds. Several of these PAs…”
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Sensitive method for the determination of lipophilic marine biotoxins in extracts of mussels and processed shellfish by high-performance liquid chromatography–tandem mass spectrometry based on enrichment by solid-phase extraction
Published in Journal of Chromatography A (22-05-2009)“…A solid-phase extraction (SPE) method for the enrichment and clean-up of lipophilic marine biotoxins from extracts of different species of bivalve molluscs and…”
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Correction to: Horses' rejection behaviour towards the presence of Senecio jacobaea L. in hay
Published in BMC veterinary research (14-02-2022)Get full text
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Horses' rejection behaviour towards the presence of Senecio jacobaea L. in hay
Published in BMC veterinary research (07-01-2022)“…Senecio jacobaea contains pyrrolizidine alkaloids that can induce severe hepatic intoxication in horses, either acute when ingested in high amounts or chronic…”
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Results of a European interlaboratory method validation study for the quantitative determination of lipophilic marine biotoxins in raw and cooked shellfish based on high-performance liquid chromatography-tandem mass spectrometry. Part I: collaborative study
Published in Analytical and bioanalytical chemistry (01-01-2011)“…A European interlaboratory collaborative study was conducted to validate a method for the quantitative determination of lipophilic marine biotoxins based on…”
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8
Fulvic Acids as Transition State of Organic Matter: Indications from High Resolution Mass Spectrometry
Published in Environmental science & technology (01-10-2006)“…Fulvic acids are one of the largest classes of dissolved organic matter, but they are poorly defined and of unclear origin. Three fulvic acid isolates of…”
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Differences in the molecular composition of fulvic acid size fractions detected by size-exclusion chromatography–on line Fourier transform ion cyclotron resonance (FTICR–) mass spectrometry
Published in Water research (Oxford) (2008)“…Size-exclusion chromatography was coupled to electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (SEC–FTICR–MS) to separate a…”
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10
Risiken von Pyrrolizidinalkaloiden in Tee und Kräutertee
Published in Journal für Kulturpflanzen (01-04-2020)“…Pyrrolizidinalkaloide (PA) sind sekundäre Pflanzeninhaltsstoffe, die von einer Vielzahl von Pflanzen gebildet werden und u. a. zur Abwehr von Fraßfeinden…”
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Rumen Metabolism of Senecio Pyrrolizidine Alkaloids May Explain Why Cattle Tolerate Higher Doses Than Monogastric Species
Published in Journal of agricultural and food chemistry (24-08-2022)“…Rumen metabolism of Senecio pyrrolizidine alkaloids (PAs) and their N-oxide forms was studied by mass spectrometry in in vitro batch culture incubates and…”
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In vitro metabolism of pyrrolizidine alkaloids – Metabolic degradation and GSH conjugate formation of different structure types
Published in Food and chemical toxicology (01-01-2020)“…Pyrrolizidine alkaloid (PA) forming plants are found worldwide and may contaminate food products at levels being of concern for human health. Due to the high…”
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Cannabinoid contents in hemp teas and estimation of their transfer into tea infusions
Published in Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment (03-07-2023)“…This study focused on the investigation of cannabinoid profiles and contents of 23 different hemp teas and on the individual transfer of 16 cannabinoids from…”
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Human CYP3A4-mediated toxification of the pyrrolizidine alkaloid lasiocarpine
Published in Food and chemical toxicology (01-08-2019)“…Pyrrolizidine alkaloids (PA) are widely distributed phytotoxins contaminating food and feed. Hepatic enzymes are considered to bioactivate PA. Previous studies…”
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Pyrrolizidine alkaloid profiling of four Boraginaceae species from Northern Germany and implications for the analytical scope proposed for monitoring of maximum levels
Published in Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment (02-08-2020)“…Pyrrolizidine alkaloids (PAs) and their corresponding N-oxides (PANOs) have been determined in food and feed at levels relevant for consumer health. More than…”
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Genetic and chemical diversity of the toxic herb Jacobaea vulgaris Gaertn. (syn. Senecio jacobaea L.) in Northern Germany
Published in Phytochemistry (Oxford) (01-04-2020)“…Tansy ragwort, Jacobaea vulgaris Gaertn. (syn. Senecio jacobaea L.), is a common Asteraceae in Europe and Asia and known to be an invasive pest in several…”
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Determination of pyrrolizidine alkaloids in tea, herbal drugs and honey
Published in Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment (02-11-2014)“…Honey was previously considered to be one of the main food sources of human pyrrolizidine alkaloid (PA) exposure in Europe. However, comprehensive analyses of…”
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Selective and low transfer of pyrrolizidine alkaloids from Jacobaea vulgaris Gaertn. into muscle and liver of dairy cattle, goat and sheep
Published in Food control (01-01-2025)“…1,2-unsaturated pyrrolizidine alkaloids and their N-oxides (PA/PANO) are plant toxins that are produced by several hundreds of plant species. Due to the…”
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Pyrrolizidine alkaloids in food and phytomedicine: Occurrence, exposure, toxicity, mechanisms, and risk assessment - A review
Published in Food and chemical toxicology (01-02-2020)“…Among naturally occurring plant constituents, the 1,2-unsaturated pyrrolizidine alkaloids (in the following termed ‘PAs’) play a distinct role because of the…”
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Structural screening by multiple reaction monitoring as a new approach for tandem mass spectrometry: presented for the determination of pyrrolizidine alkaloids in plants
Published in Analytical and bioanalytical chemistry (01-11-2013)“…In tandem mass spectrometry the multiple reaction monitoring (MRM) mode is normally used for targeted analysis but this mode also has the potential to screen…”
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