Search Results - "Therriault, Joseph"

Microglial activation and tau propagate jointly across Braak stages by Pascoal, Tharick A., Benedet, Andrea L., Ashton, Nicholas J., Kang, Min Su, Therriault, Joseph, Chamoun, Mira, Savard, Melissa, Lussier, Firoza Z., Tissot, Cécile, Karikari, Thomas K., Ottoy, Julie, Mathotaarachchi, Sulantha, Stevenson, Jenna, Massarweh, Gassan, Schöll, Michael, de Leon, Mony J., Soucy, Jean-Paul, Edison, Paul, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, Rosa-Neto, Pedro

“…Compelling experimental evidence suggests that microglial activation is involved in the spread of tau tangles over the neocortex in Alzheimer’s disease (AD)…”
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Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages by Pascoal, Tharick A, Benedet, Andrea L, Tudorascu, Dana L, Therriault, Joseph, Mathotaarachchi, Sulantha, Savard, Melissa, Lussier, Firoza Z, Tissot, Cécile, Chamoun, Mira, Kang, Min Su, Stevenson, Jenna, Massarweh, Gassan, Guiot, Marie-Christine, Soucy, Jean-Paul, Gauthier, Serge, Rosa-Neto, Pedro

“…Tracking longitudinal tau tangles accumulation across the Alzheimer's disease continuum is crucial to better understand the natural history of tau pathology…”
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Aβ-induced vulnerability propagates via the brain’s default mode network by Pascoal, Tharick A., Mathotaarachchi, Sulantha, Kang, Min Su, Mohaddes, Sara, Shin, Monica, Park, Ah Yeon, Parent, Maxime J., Benedet, Andrea L., Chamoun, Mira, Therriault, Joseph, Hwang, Heungsun, Cuello, A. Claudio, Misic, Bratislav, Soucy, Jean-Paul, Aston, John A. D., Gauthier, Serge, Rosa-Neto, Pedro

“…The link between brain amyloid-β (Aβ), metabolism, and dementia symptoms remains a pressing question in Alzheimer’s disease. Here, using positron emission…”
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In vivo quantification of neurofibrillary tangles with [ 18 F]MK-6240 by Pascoal, Tharick A, Shin, Monica, Kang, Min Su, Chamoun, Mira, Chartrand, Daniel, Mathotaarachchi, Sulantha, Bennacef, Idriss, Therriault, Joseph, Ng, Kok Pin, Hopewell, Robert, Bouhachi, Reda, Hsiao, Hung-Hsin, Benedet, Andrea L, Soucy, Jean-Paul, Massarweh, Gassan, Gauthier, Serge, Rosa-Neto, Pedro

“…Imaging agents capable of quantifying the brain's tau aggregates will allow a more precise staging of Alzheimer's disease (AD). The aim of the present study…”
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Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease by Ashton, Nicholas J., Benedet, Andréa L., Pascoal, Tharick A., Karikari, Thomas K., Lantero-Rodriguez, Juan, Brum, Wagner S., Mathotaarachchi, Sulantha, Therriault, Joseph, Savard, Melissa, Chamoun, Mira, Stoops, Erik, Francois, Cindy, Vanmechelen, Eugeen, Gauthier, Serge, Zimmer, Eduardo R., Zetterberg, Henrik, Blennow, Kaj, Rosa-Neto, Pedro

“…Phosphorylated tau (p-tau) epitopes in cerebrospinal fluid (CSF) are accurate biomarkers for a pathological and clinical diagnosis of Alzheimer's disease (AD)…”
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Biomarker modeling of Alzheimer's disease using PET-based Braak staging by Therriault, Joseph, Pascoal, Tharick A, Lussier, Firoza Z, Tissot, Cécile, Chamoun, Mira, Bezgin, Gleb, Servaes, Stijn, Benedet, Andrea L, Ashton, Nicholas J, Karikari, Thomas K, Lantero-Rodriguez, Juan, Kunach, Peter, Wang, Yi-Ting, Fernandez-Arias, Jaime, Massarweh, Gassan, Vitali, Paolo, Soucy, Jean-Paul, Saha-Chaudhuri, Paramita, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, Rosa-Neto, Pedro

“…Gold-standard diagnosis of Alzheimer's disease (AD) relies on histopathological staging systems. Using the topographical information from [ F]MK6240 tau…”
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Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer’s disease by Kang, Min Su, Aliaga, Arturo Aliaga, Shin, Monica, Mathotaarachchi, Sulantha, Benedet, Andrea L., Pascoal, Tharick A., Therriault, Joseph, Chamoun, Mira, Savard, Melissa, Devenyi, Gabriel A., Mathieu, Axel, Chakravarty, M. Mallar, Sandelius, Åsa, Blennow, Kaj, Zetterberg, Henrik, Soucy, Jean-Paul, Cuello, A. Claudio, Massarweh, Gassan, Gauthier, Serge, Rosa-Neto, Pedro

“…Neurofilament light chain (NFL) measurement has been gaining strong support as a clinically useful neuronal injury biomarker for various neurodegenerative…”
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Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer's disease by Terada, Tatsuhiro, Therriault, Joseph, Kang, Min Su Peter, Savard, Melissa, Pascoal, Tharick Ali, Lussier, Firoza, Tissot, Cecile, Wang, Yi-Ting, Benedet, Andrea, Matsudaira, Takashi, Bunai, Tomoyasu, Obi, Tomokazu, Tsukada, Hideo, Ouchi, Yasuomi, Rosa-Neto, Pedro

“…Mitochondrial electron transport chain abnormalities have been reported in postmortem pathological specimens of Alzheimer's disease (AD). However, it remains…”
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Cryo-EM structure of Alzheimer’s disease tau filaments with PET ligand MK-6240 by Kunach, Peter, Vaquer-Alicea, Jaime, Smith, Matthew S., Monistrol, Jim, Hopewell, Robert, Moquin, Luc, Therriault, Joseph, Tissot, Cecile, Rahmouni, Nesrine, Massarweh, Gassan, Soucy, Jean-Paul, Guiot, Marie-Christine, Shoichet, Brian K., Rosa-Neto, Pedro, Diamond, Marc I., Shahmoradian, Sarah H.

“…Positron Emission Tomography (PET) ligands have advanced Alzheimer’s disease (AD) diagnosis and treatment. Using autoradiography and cryo-EM, we identify AD…”
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[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease by Pascoal, Tharick A., Chamoun, Mira, Lax, Elad, Wey, Hsiao-Ying, Shin, Monica, Ng, Kok Pin, Kang, Min Su, Mathotaarachchi, Sulantha, Benedet, Andrea L., Therriault, Joseph, Lussier, Firoza Z., Schroeder, Frederick A., DuBois, Jonathan M., Hightower, Baileigh G., Gilbert, Tonya M., Zürcher, Nicole R., Wang, Changning, Hopewell, Robert, Chakravarty, Mallar, Savard, Melissa, Thomas, Emilie, Mohaddes, Sara, Farzin, Sarah, Salaciak, Alyssa, Tullo, Stephanie, Cuello, A. Claudio, Soucy, Jean-Paul, Massarweh, Gassan, Hwang, Heungsun, Kobayashi, Eliane, Hyman, Bradley T., Dickerson, Bradford C., Guiot, Marie-Christine, Szyf, Moshe, Gauthier, Serge, Hooker, Jacob M., Rosa-Neto, Pedro

“…Alzheimer’s disease (AD) is characterized by the brain accumulation of amyloid-β and tau proteins. A growing body of literature suggests that epigenetic…”
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A blood-based biomarker workflow for optimal tau-PET referral in memory clinic settings by Brum, Wagner S., Cullen, Nicholas C., Therriault, Joseph, Janelidze, Shorena, Rahmouni, Nesrine, Stevenson, Jenna, Servaes, Stijn, Benedet, Andrea L., Zimmer, Eduardo R., Stomrud, Erik, Palmqvist, Sebastian, Zetterberg, Henrik, Frisoni, Giovanni B., Ashton, Nicholas J., Blennow, Kaj, Mattsson-Carlgren, Niklas, Rosa-Neto, Pedro, Hansson, Oskar

“…Blood-based biomarkers for screening may guide tau positrion emissition tomography (PET) scan referrals to optimize prognostic evaluation in Alzheimer’s…”
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Tau follows principal axes of functional and structural brain organization in Alzheimer’s disease by Ottoy, Julie, Kang, Min Su, Tan, Jazlynn Xiu Min, Boone, Lyndon, Vos de Wael, Reinder, Park, Bo-yong, Bezgin, Gleb, Lussier, Firoza Z., Pascoal, Tharick A., Rahmouni, Nesrine, Stevenson, Jenna, Fernandez Arias, Jaime, Therriault, Joseph, Hong, Seok-Jun, Stefanovic, Bojana, McLaurin, JoAnne, Soucy, Jean-Paul, Gauthier, Serge, Bernhardt, Boris C., Black, Sandra E., Rosa-Neto, Pedro, Goubran, Maged

“…Alzheimer’s disease (AD) is a brain network disorder where pathological proteins accumulate through networks and drive cognitive decline. Yet, the role of…”
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Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer's disease by Zhang, Hua, Therriault, Joseph, Kang, Min Su, Ng, Kok Pin, Pascoal, Tharick A, Rosa-Neto, Pedro, Gauthier, Serge

“…There is accumulating evidence that synaptic loss precedes neuronal loss and correlates best with impaired memory formation in Alzheimer's disease (AD)…”
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Mitochondrial complex I abnormalities underlie neurodegeneration and cognitive decline in Alzheimer’s disease by Terada, Tatsuhiro, Therriault, Joseph, Kang, Min Su, Savard, Melissa, Pascoal, Tharick Ali, Lussier, Firoza, Tissot, Cecile, Wang, Yi‐Ting, Benedet, Andrea, Poltronetti, Nina Margherita, Ottoy, Julie, Arias, Jaime Frenandez, Bezgin, Gleb, Matsudaira, Takashi, Bunai, Tomoyasu, Obi, Tomokazu, Tsukada, Hideo, Ouchi, Yasuomi, Rosa‐Neto, Pedro

“…Background and purpose Abnormal mitochondrial metabolism has been described in the Alzheimer's disease (AD) brain. However, the relationship between AD…”
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Neurofilament light as a biomarker of axonal degeneration in patients with mild cognitive impairment and Alzheimer's disease by Chen, Yi, Therriault, Joseph, Luo, Jing, Ba, Maowen, Zhang, Hua, Initiative, Alzheimer's Disease Neuroimaging

“…Cerebrospinal fluid neurofilament light and plasma neurofilament light concentrations are elevated in patients with mild cognitive impairment and Alzheimer's…”
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Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240 tau-PET by Tissot, Cécile, Therriault, Joseph, Kunach, Peter, L Benedet, Andréa, Pascoal, Tharick A., Ashton, Nicholas J., Karikari, Thomas K., Servaes, Stijn, Lussier, Firoza Z., Chamoun, Mira, Tudorascu, Dana L., Stevenson, Jenna, Rahmouni, Nesrine, Poltronetti, Nina Margherita, Pallen, Vanessa, Bezgin, Gleb, Kang, Min Su, Mathotaarachchi, Sulantha S., Wang, Yi-Ting, Fernandez Arias, Jaime, Ferreira, Pamela Cristina Lukasewicz, Ferrari-Souza, João Pedro, Vanmechelen, Eugeen, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, Rosa-Neto, Pedro

“…Tau in Alzheimer's disease (AD) is assessed via cerebrospinal fluid (CSF) and Positron emission tomography (PET). Novel methods to detect phosphorylated tau…”
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Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's disease by Tissot, Cécile, L Benedet, Andréa, Therriault, Joseph, Pascoal, Tharick A, Lussier, Firoza Z, Saha-Chaudhuri, Paramita, Chamoun, Mira, Savard, Melissa, Mathotaarachchi, Sulantha S, Bezgin, Gleb, Wang, Yi-Ting, Fernandez Arias, Jaime, Rodriguez, Juan Lantero, Snellman, Anniina, Ashton, Nicholas J, Karikari, Thomas K, Blennow, Kaj, Zetterberg, Henrik, De Villers-Sidani, Etienne, Huot, Philippe, Gauthier, Serge, Rosa-Neto, Pedro

“…To investigate the association of plasma pTau181, assessed with a new immunoassay, with neurodegeneration of white matter and gray matter cross-sectionally and…”
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The Effects of CSF Neurogranin and APOE ε4 on Cognition and Neuropathology in Mild Cognitive Impairment and Alzheimer's Disease by Fan, Yulan, Gao, Ying, Therriault, Joseph, Luo, Jing, Ba, Maowen, Zhang, Hua

“…Cerebrospinal fluid (CSF) measurements of neurogranin (Ng) have emerged as a promising biomarker for cognitive decline in mild cognitive impairment (MCI) and…”
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Author Correction: [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease by Pascoal, Tharick A., Chamoun, Mira, Lax, Elad, Wey, Hsiao-Ying, Shin, Monica, Ng, Kok Pin, Kang, Min Su, Mathotaarachchi, Sulantha, Benedet, Andrea L., Therriault, Joseph, Lussier, Firoza Z., Schroeder, Frederick A., DuBois, Jonathan M., Hightower, Baileigh G., Gilbert, Tonya M., Zürcher, Nicole R., Wang, Changning, Hopewell, Robert, Chakravarty, Mallar, Savard, Melissa, Thomas, Emilie, Mohaddes, Sara, Farzin, Sarah, Salaciak, Alyssa, Tullo, Stephanie, Cuello, A. Claudio, Soucy, Jean-Paul, Massarweh, Gassan, Hwang, Heungsun, Kobayashi, Eliane, Hyman, Bradley T., Dickerson, Bradford C., Guiot, Marie-Christine, Szyf, Moshe, Gauthier, Serge, Hooker, Jacob M., Rosa-Neto, Pedro

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In-vivo neuronal dysfunction by Aβ and tau overlaps with brain-wide inflammatory mechanisms in Alzheimer's disease by Sanchez-Rodriguez, Lazaro M, Khan, Ahmed F, Adewale, Quadri, Bezgin, Gleb, Therriault, Joseph, Fernandez-Arias, Jaime, Servaes, Stijn, Rahmouni, Nesrine, Tissot, Cécile, Stevenson, Jenna, Jiang, Hongxiu, Chai, Xiaoqian, Carbonell, Felix, Rosa-Neto, Pedro, Iturria-Medina, Yasser

“…The molecular mechanisms underlying neuronal dysfunction in Alzheimer's disease (AD) remain uncharacterized. Here, we identify genes, molecular pathways and…”
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