Search Results - "Theron, A. J."

Pro-inflammatory interactions of streptolysin O toxin with human neutrophils in vitro by Joseph, D, Theron, A J, Feldman, C, Anderson, R, Tintinger, G R

“…The recent global resurgence of severe infections caused by the Group A streptococcus (GAS) pathogen, , has focused attention on this microbial pathogen, which…”
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Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function by Anderson, Ronald, Gravett, C. M., Tintinger, G. R., Steel, Helen C., Theron, A. J., Feldman, Charles

“…Cysteinyl leukotrienes (cysLTs) are produced predominantly by cells of the innate immune system, especially basophils, eosinophils, mast cells, and…”
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Pneumolysin activates neutrophil extracellular trap formation by Nel, J. G., Theron, A. J., Durandt, C., Tintinger, G. R., Pool, R., Mitchell, T. J., Feldman, C., Anderson, R.

“…Summary The primary objective of the current study was to investigate the potential of the pneumococcal toxin, pneumolysin (Ply), to activate neutrophil…”
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Interactive inhibitory effects of formoterol and montelukast on activated human neutrophils by GRAVETT, C. M, THERON, A. J, STEEL, H. C, TINTINGER, G. R, COCKERAN, R, FELDMAN, C, ANDERSON, R

“…The research question addressed in the current study was: do formoterol (1 and 10 nM) and montelukast (2 μM) possess interactive inhibitory effects on…”
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Characterization of the interactions of the pneumolysoid, Δ6 PLY, with human neutrophils in vitro by Cockeran, R, Steel, H.C, Theron, A.J, Mitchell, T.J, Feldman, C, Anderson, R

“…Highlights ► Δ6 PLY is a prototype pneumococcal vaccine candidate. ► Δ6 PLY fails to produce a pro-inflammatory response (unlike pneumolysin), underscores its…”
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Representation of coal and coal derivatives in process modelling by Theron, J A, le Roux, E

“…This paper provides guidelines on performing mass and energy balance modeling involving coal and coal derivatives. Usually, the inputs to a pyrometallurgical…”
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Itraconazole‐mediated inhibition of calcium entry into platelet‐activating factor‐stimulated human neutrophils is due to interference with production of leukotriene B4 by Steel, H. C., Tintinger, G. R., Theron, A. J., Anderson, R.

“…Summary The primary objective of this study was to probe the involvement of leukotriene B4 (LTB4) in itraconazole (0·1–5 µM)‐mediated inhibition of Ca2+ uptake…”
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Posaconazole attenuates leukotriene B4 release and uptake of calcium by chemoattractant-activated human neutrophils: a potential strategy to control neutrophil-mediated inflammation by Steel, H. C., Theron, A. J., Tintinger, G. R., Anderson, R.

“…Objectives This study was designed to investigate the neutrophil-targeted anti-inflammatory potential of posaconazole (0.1–5 µM, equivalent to 0.7–3.9 mg/L) by…”
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Attenuation of increase in circulating cortisol and enhancement of the acute phase protein response in vitamin C-supplemented ultramarathoners by Peters, E M, Anderson, R, Theron, A J

“…Supplementary vitamin C (2 x 500 mg tablets daily) or a matched placebo was administered to 10 and 6 ultramarathon athletes respectively for 7 days prior to…”
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Oxidative stress in pre-eclampsia by Bowen, R S, Moodley, J, Dutton, M F, Theron, A J

“…The objective of this study was to test the hypothesis that maternal plasma, cord plasma and placental tissue lipid peroxidation products are increased and…”
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Effect of rolipram and dibutyryl cyclic AMP on resequestration of cytosolic calcium in FMLP‐activated human neutrophils by Anderson, R, Mahomed, A Goolam, Theron, A J, Ramafi, G, Feldman, C

“…We have investigated the effects of the selective phosphodiesterase (PDE) type 4 inhibitor, rolipram (0.01–1 μM) on cytosolic Ca2+ fluxes in FMLP‐activated…”
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Accelerated calcium influx and hyperactivation of neutrophils in chronic granulomatous disease by Tintinger, G. R., Theron, A. J., Steel, H. C., Anderson, R.

“…The relationship between activation of NADPH‐oxidase, alterations in membrane potential and triggering of Ca2+ fluxes in human phagocytes has been investigated…”
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Accelerated resequestration of cytosolic calcium and suppression of the pro‐inflammatory activities of human neutrophils by CGS 21680 in vitro by Anderson, R, Visser, S S, Ramafi, G, Theron, A J

“…We have investigated the effects of the adenosine A2A receptor agonist CGS 21680 (0.01–1 μM) on reactive oxidant production by, and elastase release from…”
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Influence of antimicrobial chemotherapy and smoking status on the plasma concentrations of vitamin C, vitamin E, β-carotene, acute phase reactants, iron and lipid peroxides in patients with pulmonary tuberculosis by PLIT, M. L, THERON, A. J, FICKL, H, VAN RENSBURG, C. E. J, PENDEL, S, ANDERSON, R

“…SETTING: Inflammation-related oxidative stress has been implicated in the pathogenesis of lung fibrosis and dysfunction in patients with pulmonary…”
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Investigation of the anti-inflammatory and membrane-stabilizing potential of spiramycin in vitro by Theron, A. J., Feldman, C., Anderson, R.

“…The effects of the 16-member macrolide spiramycin (2.5–80 mg/L) and the 14-member agent clarithromycin on the production of superoxide by activated human…”
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Practical approach to diagnosis and management of primary immunodeficiency diseases by Rossouw, T.M., Theron, A.J., Anderson, R.

“…The occurrence of primary immunodeficiency diseases (PIDs) is low compared to that of immune-mediated disorders of autoimmune or atopic origin. However,…”
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Acute Phase Proteins and Stress Hormone Responses in Patients with Newly Diagnosed Active Pulmonary Tuberculosis by Opolot, J. O., Theron, A. J., Anderson, R., Feldman, C.

“…Introduction Despite the high burden of disease, there have been surprisingly few studies of the acute phase and plasma catecholamine/cortisol stress hormone…”
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Vitamin E attenuates the injurious effects of bioactive phospholipids on human ciliated epithelium in vitro by Feldman, C, Anderson, R, Theron, A.J, Steel, H.C, van Rensburg, C.E.J, Cole, P.J, Wilson, R

“…Bioactive phospholipids (PL), particularly lysophosphatidylcholine (LPC), are being increasingly implicated in the pathogenesis of various acute and chronic…”
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Anti‐inflammatory, membrane‐stabilizing interactions of salmeterol with human neutrophils in vitro by Anderson, R., Feldman, C., Theron, A.J., Ramafi, G., Cole, P.J., Wilson, R.

“…1 We have investigated the effects of salmeterol (0.3–50 μ) on several pro‐inflammatory activities of human neutrophils in vitro. 2 Oxidant production by FMLP‐…”
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Mycelial Sensitivity Assay of Postharvest Grey Mould from ‘Forelle’ Pears to Anilinopyrimidine Fungicide Pyrimethanil by Rochefort, J, Theron, J. A, Lennox, C. L

“…In South Africa, significant postharvest losses occur in the ‘Forelle’ pear cultivar due to secondary infections caused by grey mould pathogen Botrytis…”
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