role of neutrophils and monocytic cells in controlling the initiation of Clostridium perfringens gas gangrene

role of neutrophils and monocytic cells in controlling the initiation of Clostridium perfringens gas gangrene

Clostridium perfringens is a common cause of the fatal disease gas gangrene (myonecrosis). Established gas gangrene is notable for a profound absence of neutrophils and monocytic cells (phagocytes), and it has been suggested that the bactericidal activities of these cells play an insignificant role...

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Bibliographic Details
Published in:FEMS immunology and medical microbiology Vol. 50; no. 1; pp. 86 - 93
Main Authors: O'Brien, David K, Therit, Blair H, Woodman, Michael E, Melville, Stephen B
Format: Journal Article
Language:English
Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01-06-2007
Blackwell Publishing Ltd
Blackwell
Subjects:
Animals
Biological and medical sciences
Clostridium perfringens
Clostridium perfringens - immunology
Female
Fundamental and applied biological sciences. Psychology
gas gangrene
Gas Gangrene - blood
Gas Gangrene - immunology
Gas Gangrene - microbiology
macrophages
Mice
Mice, Inbred BALB C
Microbiology
monocytes
Monocytes - immunology
neutrophils
Neutrophils - immunology
Phagocytes - immunology
monocytes
macrophages
gas gangrene
neutrophils
Microbiology
Monocyte
Gas gangrene
Clostridiales
Clostridium perfringens
Infection
Immunology
Clostridiaceae
Bacteriosis
Bacteria
Neutrophil
Macrophage
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Summary:Clostridium perfringens is a common cause of the fatal disease gas gangrene (myonecrosis). Established gas gangrene is notable for a profound absence of neutrophils and monocytic cells (phagocytes), and it has been suggested that the bactericidal activities of these cells play an insignificant role in controlling the progression of the infection. However, large inocula of bacteria are needed to establish an infection in experimental animals, suggesting phagocytes may play a role in inhibiting the initiation of gangrene. Examination of tissue sections of mice infected with a lethal (1 x 10⁹) or sublethal (1 x 10⁶) inoculum of C. perfringens revealed that phagocyte infiltration in the first 3 h postinfection was inhibited with a lethal dose but not with a sublethal dose, indicating that exclusion of phagocytes begins very early in the infection cycle. Experiments in which mice were depleted of either circulating monocytes or neutrophils before infection with C. perfringens showed that monocytes play a role in inhibiting the onset of gas gangrene at intermediate inocula but, although neutrophils can slow the onset of the infection, they are not protective. These results suggest that treatments designed to increase monocyte infiltration and activate macrophages may lead to increased resistance to the initiation of gas gangrene.
Bibliography:http://dx.doi.org/10.1111/j.1574-695X.2007.00235.x
Editor: Patrik Bavoil
David K. O'Brien, Division of Bacteriology, United States Army Medical Research Institute for Infectious Diseases, Fort Detrick, 1425 Porter Street, Frederick, MD 21702, USA.
Michael E. Woodman, Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536‐0298, USA.
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SourceType-Scholarly Journals-1
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content type line 23
ISSN:0928-8244
1574-695X
DOI:10.1111/j.1574-695X.2007.00235.x