Search Results - "Theresia, Kraft"

Preclinical development of a miR-132 inhibitor for heart failure treatment by Foinquinos, Ariana, Batkai, Sandor, Genschel, Celina, Viereck, Janika, Rump, Steffen, Gyöngyösi, Mariann, Traxler, Denise, Riesenhuber, Martin, Spannbauer, Andreas, Lukovic, Dominika, Weber, Natalie, Zlabinger, Katrin, Hašimbegović, Ena, Winkler, Johannes, Fiedler, Jan, Dangwal, Seema, Fischer, Martin, de la Roche, Jeanne, Wojciechowski, Daniel, Kraft, Theresia, Garamvölgyi, Rita, Neitzel, Sonja, Chatterjee, Shambhabi, Yin, Xiaoke, Bär, Christian, Mayr, Manuel, Xiao, Ke, Thum, Thomas

“…Despite proven efficacy of pharmacotherapies targeting primarily global neurohormonal dysregulation, heart failure (HF) is a growing pandemic with increasing…”
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Skeletal muscle derived Musclin protects the heart during pathological overload by Szaroszyk, Malgorzata, Kattih, Badder, Martin-Garrido, Abel, Trogisch, Felix A., Dittrich, Gesine M., Grund, Andrea, Abouissa, Aya, Derlin, Katja, Meier, Martin, Holler, Tim, Korf-Klingebiel, Mortimer, Völker, Katharina, Garfias Macedo, Tania, Pablo Tortola, Cristina, Boschmann, Michael, Huang, Nora, Froese, Natali, Zwadlo, Carolin, Malek Mohammadi, Mona, Luo, Xiaojing, Wagner, Michael, Cordero, Julio, Geffers, Robert, Batkai, Sandor, Thum, Thomas, Bork, Nadja, Nikolaev, Viacheslav O., Müller, Oliver J., Katus, Hugo A., El-Armouche, Ali, Kraft, Theresia, Springer, Jochen, Dobreva, Gergana, Wollert, Kai C., Fielitz, Jens, von Haehling, Stephan, Kuhn, Michaela, Bauersachs, Johann, Heineke, Joerg

“…Cachexia is associated with poor prognosis in chronic heart failure patients, but the underlying mechanisms of cachexia triggered disease progression remain…”
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Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus by López-Dávila, Alfredo Jesús, Weber, Natalie, Kraft, Theresia, Matinmehr, Faramarz, Arias-Hidalgo, Mariela, Fernández, Julián, Lomonte, Bruno, Gutiérrez, José María

“…Viperid snake venoms contain a unique family of cytotoxic proteins, the Lys49 PLA 2 homologs, which are devoid of enzymatic activity but disrupt the integrity…”
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Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia by Nayak, Arnab, Lopez-Davila, Alfredo J., Kefalakes, Ekaterini, Holler, Tim, Kraft, Theresia, Amrute-Nayak, Mamta

“…Precise assembly of the sarcomere, a force-generating unit in striated muscles, is critical for muscle contraction. Defective sarcomere organization is linked…”
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SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway by KUMARSWAMY, Regalla, LYON, Alexander R, HARDING, Sian E, THUM, Thomas, VOLKMANN, Ingo, MILLS, Adam M, BRETTHAUER, Julia, PAHUJA, Aanchal, GEERS-KNÖRR, Cornelia, KRAFT, Theresia, HAJJAR, Roger J, MACLEOD, Kenneth T

“…Impaired myocardial sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) activity is a hallmark of failing hearts, and SERCA2a gene therapy improves cardiac…”
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Continuous WNT Control Enables Advanced hPSC Cardiac Processing and Prognostic Surface Marker Identification in Chemically Defined Suspension Culture by Halloin, Caroline, Schwanke, Kristin, Löbel, Wiebke, Franke, Annika, Szepes, Monika, Biswanath, Santoshi, Wunderlich, Stephanie, Merkert, Sylvia, Weber, Natalie, Osten, Felix, de la Roche, Jeanne, Polten, Felix, Christoph Wollert, Kai, Kraft, Theresia, Fischer, Martin, Martin, Ulrich, Gruh, Ina, Kempf, Henning, Zweigerdt, Robert

“…Aiming at clinical translation, robust directed differentiation of human pluripotent stem cells (hPSCs), preferentially in chemically defined conditions, is a…”
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Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the Drosophila heart by Auxerre-Plantié, Emilie, Nielsen, Tanja, Grunert, Marcel, Olejniczak, Olga, Perrot, Andreas, Özcelik, Cemil, Harries, Dennis, Matinmehr, Faramarz, Dos Remedios, Cristobal, Mühlfeld, Christian, Kraft, Theresia, Bodmer, Rolf, Vogler, Georg, Sperling, Silke R

“…The causal genetic underpinnings of congenital heart diseases, which are often complex and multigenic, are still far from understood. Moreover, there are also…”
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Blood-based protein profiling identifies serum protein c-KIT as a novel biomarker for hypertrophic cardiomyopathy by Sonnenschein, Kristina, Fiedler, Jan, de Gonzalo-Calvo, David, Xiao, Ke, Pfanne, Angelika, Just, Annette, Zwadlo, Carolin, Soltani, Samira, Bavendiek, Udo, Kraft, Theresia, Dos Remedios, Cristobal, Cebotari, Serghei, Bauersachs, Johann, Thum, Thomas

“…Hypertrophic cardiomyopathy (HCM) is one of the most common hereditary heart diseases and can be classified into an obstructive (HOCM) and…”
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Efficient Knock-in of a Point Mutation in Porcine Fibroblasts Using the CRISPR/Cas9- GMNN Fusion Gene by Gerlach, Max, Kraft, Theresia, Brenner, Bernhard, Petersen, Björn, Niemann, Heiner, Montag, Judith

“…During CRISPR/Cas9 mediated genome editing, site-specific double strand breaks are introduced and repaired either unspecific by non-homologous end joining…”
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Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms by Iorga, Bogdan, Schwanke, Kristin, Weber, Natalie, Wendland, Meike, Greten, Stephan, Piep, Birgit, Dos Remedios, Cristobal G, Martin, Ulrich, Zweigerdt, Robert, Kraft, Theresia, Brenner, Bernhard

“…Characterizing the contractile function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is key for advancing their utility for cellular…”
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Protein-free media for cardiac differentiation of hPSCs in 2000 mL suspension culture by Kriedemann, Nils, Manstein, Felix, Hernandez-Bautista, Carlos A, Ullmann, Kevin, Triebert, Wiebke, Franke, Annika, Mertens, Mira, Stein, Inês Carvalheira Arnaut Pombeiro, Leffler, Andreas, Witte, Merlin, Askurava, Tamari, Fricke, Veronika, Gruh, Ina, Piep, Birgit, Kowalski, Kathrin, Kraft, Theresia, Zweigerdt, Robert

“…Commonly used media for the differentiation of human pluripotent stem cells into cardiomyocytes (hPSC-CMs) contain high concentrations of proteins, in…”
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Burst-Like Transcription of Mutant and Wildtype MYH7 -Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy by Montag, Judith, Kowalski, Kathrin, Makul, Mirza, Ernstberger, Pia, Radocaj, Ante, Beck, Julia, Becker, Edgar, Tripathi, Snigdha, Keyser, Britta, Mühlfeld, Christian, Wissel, Kirsten, Pich, Andreas, van der Velden, Jolanda, Dos Remedios, Cristobal G, Perrot, Andreas, Francino, Antonio, Navarro-López, Francesco, Brenner, Bernhard, Kraft, Theresia

“…Hypertrophic Cardiomyopathy (HCM) has been related to many different mutations in more than 20 different, mostly sarcomeric proteins. While development of the…”
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AQUA Mutant Protein Quantification of Endomyocardial Biopsy-Sized Samples From a Patient With Hypertrophic Cardiomyopathy by Becker, Edgar, Francino, Antonio, Pich, Andreas, Perrot, Andreas, Kraft, Theresia, Radocaj, Ante

“…In genetic diseases like hypertrophic cardiomyopathy, reliable quantification of the expression level of mutant protein can play an important role in disease…”
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TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation by Grund, Andrea, Szaroszyk, Malgorzata, Korf‐Klingebiel, Mortimer, Malek Mohammadi, Mona, Trogisch, Felix A, Schrameck, Ulrike, Gigina, Anna, Tiedje, Christopher, Gaestel, Matthias, Kraft, Theresia, Hegermann, Jan, Batkai, Sandor, Thum, Thomas, Perrot, Andreas, Remedios, Cris dos, Riechert, Eva, Völkers, Mirko, Doroudgar, Shirin, Jungmann, Andreas, Bauer, Ralf, Yin, Xiaoke, Mayr, Manuel, Wollert, Kai C, Pich, Andreas, Xiao, Hua, Katus, Hugo A, Bauersachs, Johann, Müller, Oliver J, Heineke, Joerg

“…Pathological cardiac overload induces myocardial protein synthesis and hypertrophy, which predisposes to heart failure. To inhibit hypertrophy therapeutically,…”
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Mitogen-Activated Protein Kinase-Activated Protein Kinases 2 and 3 Regulate SERCA2a Expression and Fiber Type Composition To Modulate Skeletal Muscle and Cardiomyocyte Function by Scharf, Madeleine, Neef, Stefan, Freund, Robert, Geers-Knörr, Cornelia, Franz-Wachtel, Mirita, Brandis, Almuth, Krone, Dorothee, Schneider, Heike, Groos, Stephanie, Menon, Manoj B., Chang, Kin-Chow, Kraft, Theresia, Meissner, Joachim D., Boheler, Kenneth R., Maier, Lars S., Gaestel, Matthias, Scheibe, Renate J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cycling Cross-Bridges Contribute to Thin Filament Activation in Human Slow-Twitch Fibers by López-Dávila, Alfredo Jesus, Chalovich, Joseph M, Zittrich, Stefan, Piep, Birgit, Matinmehr, Faramarz, Málnási-Csizmadia, Andras, Rauscher, Anna Á, Kraft, Theresia, Brenner, Bernhard, Stehle, Robert

“…It has been shown that not only calcium but also strong binding myosin heads contribute to thin filament activation in isometrically contracting animal…”
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Muscle RING‐finger 2 and 3 maintain striated‐muscle structure and function by Lodka, Dörte, Pahuja, Aanchal, Geers‐Knörr, Cornelia, Scheibe, Renate J., Nowak, Marcel, Hamati, Jida, Köhncke, Clemens, Purfürst, Bettina, Kanashova, Tamara, Schmidt, Sibylle, Glass, David J., Morano, Ingo, Heuser, Arnd, Kraft, Theresia, Bassel‐Duby, Rhonda, Olson, Eric N., Dittmar, Gunnar, Sommer, Thomas, Fielitz, Jens

“…Background The Muscle‐specific RING‐finger (MuRF) protein family of E3 ubiquitin ligases is important for maintenance of muscular structure and function. MuRF…”
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Transcriptional bursts and heterogeneity among cardiomyocytes in hypertrophic cardiomyopathy by Burkart, Valentin, Kowalski, Kathrin, Aldag-Niebling, David, Beck, Julia, Frick, Dirk Alexander, Holler, Tim, Radocaj, Ante, Piep, Birgit, Zeug, Andre, Hilfiker-Kleiner, Denise, dos Remedios, Cristobal G., van der Velden, Jolanda, Montag, Judith, Kraft, Theresia

“…Transcriptional bursting is a common expression mode for most genes where independent transcription of alleles leads to different ratios of allelic mRNA from…”
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Attenuation of Cardiac Remodeling after Myocardial Infarction by Muscle LIM Protein-Calcineurin Signaling at the Sarcomeric Z-Disc by Heineke, Joerg, Ruetten, Hartmut, Willenbockel, Christian, Gross, Sandra C., Naguib, Marian, Schaefer, Arnd, Kempf, Tibor, Hilfiker-Kleiner, Denise, Caroni, Pico, Kraft, Theresia, Kaiser, Robert A., Molkentin, Jeffery D., Drexler, Helmut, Wollert, Kai C., Ignarro, Louis J.

“…Adverse left ventricular (LV) remodeling after myocardial infarction (MI) is a major cause for heart failure. Molecular modifiers of the remodeling process…”
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Differential Intranuclear Localization of Fibroblast Growth Factor-2 Isoforms and Specific Interaction with the Survival of Motoneuron Protein by Claus, Peter, Döring, Friederike, Gringel, Susanne, Müller-Ostermeyer, Frauke, Fuhlrott, Jutta, Kraft, Theresia, Grothe, Claudia

“…Fibroblast growth factor 2 (FGF-2) is an important modulator of cell growth and differentiation and a neurotrophic factor. FGF-2 occurs in isoforms, at a low…”
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