Search Results - "Thepen, T."

Microtubule-associated protein tau facilitates the targeted killing of proliferating cancer cells in vitro and in a xenograft mouse tumour model in vivo by Hristodorov, D, Mladenov, R, Pardo, A, Pham, A-T, Huhn, M, Fischer, R, Thepen, T, Barth, S

“…Background: Antibody drug conjugates (ADCs) and immunotoxins (ITs) are promising anticancer immunotherapeutics. Despite their encouraging performance in…”
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Recombinant, ETA′-based CD64 immunotoxins: improved efficacy by increased valency, both in vitro and in vivo in a chronic cutaneous inflammation model in human CD64 transgenic mice by Ribbert, T., Thepen, T., Tur, M.K., Fischer, R., Huhn, M., Barth, S.

“…Summary Background  Dysregulated, activated macrophages play a pivotal role in chronic inflammatory diseases such as arthritis and atopic dermatitis. These…”
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Efficacy of an adapted granzyme B-based anti-CD30 cytolytic fusion protein against PI-9-positive classical Hodgkin lymphoma cells in a murine model by Schiffer, S, Hansen, H P, Hehmann-Titt, G, Huhn, M, Fischer, R, Barth, S, Thepen, T

“…Tumors develop when infiltrating immune cells contribute growth stimuli, and cancer cells are selected to survive within such a cytotoxic microenvironment. One…”
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Heterogeneity within tissue-specific macrophage and dendritic cell populations during cutaneous inflammation in atopic dermatitis by Kiekens, R.C.M., Thepen, T., Oosting, A.J., Bihari, I.C., Van De Winkel, J.G.J., Bruijnzeel-Koomen, C.A.F.M., Knol, E.F.

“…Background Macrophages and dendritic cells may play a role in chronicity of atopic dermatitis (AD); however, so far only limited data are documented on the…”
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Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages by HOLT, P. G, OLIVER, J, BILYK, N, MCNENAMIN, C, MCMENAMIN, P. G, KRAAL, G, THEPEN, T

“…Class II major histocompatibility complex (Ia)-bearing dendritic cells (DC) from airway epithelium and lung parenchyma express low-moderate antigen presenting…”
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Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice by THEPEN, T, VAN ROOIJEN, N, KRAAL, G

“…A single intracheal dose of liposome-encapsuled dichloro-methylene-diphosphonate resulted in the elimination of alveolar macrophages (AM) from the lung,…”
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Expression of CD64 (FcγRI) in skin of patients with acute GVHD by van Royen-Kerkhof, A, Walraven, V, Sanders, E A M, de Weger, R, van Wichen, D F, de Koning, E, Thepen, T, van de Winkel, J G J, Leusen, J H W

“…GVHD remains a major problem in allo-SCT. We explored the presence of APC in skin biopsies of GVHD patients, using the IgG receptor CD64 expression as a…”
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Preferential expression of IgG2b in nose draining cervical lymph nodes and its putative role in mucosal tolerance induction by Van Helvoort, J. M. L. M., Samsom, J. N., Chantry, D., Jansen, W., Schadee‐Eestermans, I., Thepen, T., Mebius, R. E., Kraal, G.

“…Induction of intranasal tolerance prevents the body from eliciting unwanted immune responses against harmless antigens that enter the body through the nasal…”
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Mast Cells and Eosinophils in Feline Allergic Dermatitis: A Qualitative and Quantitative Analysis by Roosje, P.J., Koeman, J.P., Thepen, T., Willemse, T.

“…Mast cells (MCs) and eosinophils are prominent in the perivascular infiltrate of cats with allergic dermatitis. In the skin of allergic cats MCs were mainly…”
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The role of alveolar macrophages in regulation of lung inflammation by Thepen, T, Kraal, G, Holt, P G

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Cloning, characterization, and antigen specificity of T-lymphocyte subsets extracted from gingival tissue of chronic adult periodontitis patients by WASSENAAR, A, REINHARDUS, C, THEPEN, T, ABRAHAM-INPIJN, L, KIEVITS, F

“…Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Interleukin 4-Producing CD4+ T Cells in the Skin of Cats with Allergic Dermatitis by Roosje, P. J., Dean, G. A., Willemse, T., M. G. Rutten, V. P., Thepen, T.

“…Lesional skin of cats with allergic dermatitis has a cellular infiltrate and a CD4/CD8 ratio comparable to that in humans with atopic dermatitis. CD4+ helper T…”
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Regulation of IgE production in pre-sensitized animals: in vivo elimination of alveolar macrophages preferentially increases IgE responses to inhaled allergen by Thepen, T, McMenamin, C, Girn, B, Kraal, G, Holt, P G

“…Intratracheal inoculation of dichloromethylene diphosphonate encapsulated in liposomes leads to the rapid accumulation of this drug in alveolar macrophage (AM)…”
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Immunophenotyping of the cutaneous cellular infiltrate after atopy patch testing in cats with atopic dermatitis by Roosje, P.J., Thepen, T., Rutten, V.P.M.G., van den Brom, W.E., Bruijnzeel-Koomen, C.A.F.M., Willemse, T.

“…Cats with spontaneously occurring atopic dermatitis have clinical and immunocytochemical characteristics compatible with these in humans with atopic dermatitis…”
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Evaluation of variables influencing the outcome of the atopy patch test by Langeveld-Wildschut, Elisabeth G., van Marion a, Ariënne M.W., Thepen, Theo, Mudde, Geert C., Bruijnzeel, Piet L.B., Bruijnzeel-Koomen, Carla A.F.M.

“…Background: The number of positive atopy patch test (APT) results in patients with atopic eczema (AE) varies in different studies, probably because of…”
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Evaluation of the atopy patch test and the cutaneous late-phase reaction as relevant models for the study of allergic inflammation in patients with atopic eczema by Langeveld-Wildschut, Elisabeth G., Thepen, Theo, Bihari a, Ilse C., van Reijsen, Frank C., de Vries a, I.Jolanda M., Bruijnzeel, Piet L.B., Bruijnzeel-Koomen, Carla A.F.M.

“…OBJECTIVE: The study was designed to evaluate the atopy patch test (APT) and the late-phase reaction (LPR) after intracutaneous allergen injection as models…”
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Depletion of alveolar macrophages by liposome-encapsulated dichloromethylene diphosphonate by Berg, J T, Lee, S T, Thepen, T, Lee, C Y, Tsan, M F

“…Alveolar macrophages (AM) play an important role in lung biology. In this study, we demonstrated that tracheal insufflation of liposome-encapsulated…”
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Increased numbers of CD4+ and CD8+ T cells in lesional skin of cats with allergic dermatitis by Roosje, P.J, Kooten, P.J.S. van, Thepen, T, Bihari, I.C, Rutten, V.P.M.G, Koeman, J.P, Willemse, T

“…The aim of this study was to characterize T cells in the skin of cats with an allergic dermatitis histologically compatible with atopic dermatitis, since T…”
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Expression of Fc receptors for IgG during acute and chronic cutaneous inflammation in atopic dermatitis by Kiekens, R.C.M., Thepen, T., Bihari, I.C., Knol, E.F., Van De Winkel, J.G.J., Bruijnzeel-Koomen, C.A.F.M.

“…Atopic dermatitis is an allergic skin disease characterized by elevated total and antigen‐specific serum IgE and IgG4 levels. In acute and chronic cutaneous…”
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Regulation of T-cell function in lung tissue by pulmonary alveolar macrophages by STRICKLAND, D. H, THEPEN, T, KEES, U. R, KRAAL, G, HOLT, P. G

“…Collagenase digestion of perfused, lavaged rat lung yields a large population of CD5+ T cells, which on current evidence appear to be recently derived from the…”
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