Search Results - "Theofilopoulos, Argyrios N"

A regenerative approach to the treatment of multiple sclerosis by Deshmukh, Vishal A., Tardif, Virginie, Lyssiotis, Costas A., Green, Chelsea C., Kerman, Bilal, Kim, Hyung Joon, Padmanabhan, Krishnan, Swoboda, Jonathan G., Ahmad, Insha, Kondo, Toru, Gage, Fred H., Theofilopoulos, Argyrios N., Lawson, Brian R., Schultz, Peter G., Lairson, Luke L.

“…Progressive phases of multiple sclerosis are associated with inhibited differentiation of the progenitor cell population that generates the mature…”
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Type I interferons (alpha/beta) in immunity and autoimmunity by Theofilopoulos, Argyrios N, Baccala, Roberto, Beutler, Bruce, Kono, Dwight H

“…The significance of type I interferons (IFN-alpha/beta) in biology and medicine renders research on their activities continuously relevant to our understanding…”
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The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid-sensing TLRs and ligands to endolysosomes by Rimann, Ivo, Gonzalez-Quintial, Rosana, Baccala, Roberto, Kiosses, William B, Teijaro, John R, Parker, Christopher G, Li, Xiaohong, Beutler, Bruce, Kono, Dwight H, Theofilopoulos, Argyrios N

“…A function-impairing mutation (feeble) or genomic deletion of SLC15A4 abolishes responses of nucleic acid–sensing endosomal toll-like receptors (TLRs) and…”
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Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus by Baccala, Roberto, Gonzalez-Quintial, Rosana, Blasius, Amanda L., Rimann, Ivo, Ozato, Keiko, Kono, Dwight H., Beutler, Bruce, Theofilopoulos, Argyrios N.

“…In vitro evidence suggests that plasmacytoid dendritic cells (pDCs) are intimately involved in the pathogenesis of lupus. However, it remains to be determined…”
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TLRs and interferons: a central paradigm in autoimmunity by Kono, Dwight H, Baccala, Roberto, Theofilopoulos, Argyrios N

“…Investigations into the pathogenesis of lupus have largely focused on abnormalities in components of the adaptive immune system. Despite important advances,…”
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Lupus acceleration by a MAVS-activating RNA virus requires endosomal TLR signaling and host genetic predisposition by Gonzalez-Quintial, Rosana, Nguyen, Anthony, Kono, Dwight H, Oldstone, Michael B A, Theofilopoulos, Argyrios N, Baccala, Roberto

“…Viruses have long been implicated in the pathogenesis of autoimmunity, yet their contribution remains circumstantial partly due to the lack of well-documented…”
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The multiple pathways to autoimmunity by Theofilopoulos, Argyrios N, Kono, Dwight H, Baccala, Roberto

“…Autoimmunity can arise when tolerance mechanisms break down. Theofilopoulos and colleagues review how loss of peripheral tolerance, often driven by innate…”
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Type I interferon is a therapeutic target for virus-induced lethal vascular damage by Baccala, Roberto, Welch, Megan J., Gonzalez-Quintial, Rosana, Walsh, Kevin B., Teijaro, John R., Nguyen, Anthony, Ng, Cherie T., Sullivan, Brian M., Zarpellon, Alessandro, Ruggeri, Zaverio M., de la Torre, Juan Carlos, Theofilopoulos, Argyrios N., Oldstone, Michael B. A.

“…The outcome of a viral infection reflects the balance between virus virulence and host susceptibility. The clone 13 (Cl13) variant of lymphocytic…”
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Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus by Kono, Dwight H, Haraldsson, M. Katarina, Lawson, Brian R, Pollard, K. Michael, Koh, Yi Ting, Du, Xin, Arnold, Carrie N, Baccala, Roberto, Silverman, Gregg J, Beutler, Bruce A, Theofilopoulos, Argyrios N

“…Using the Unc93b1 3d mutation that selectively abolishes nucleic acid-binding Toll-like receptor (TLR) (TLR3, -7, -9) signaling, we show these endosomal TLRs…”
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Interferons as pathogenic effectors in autoimmunity by Baccala, Roberto, Kono, Dwight H., Theofilopoulos, Argyrios N.

“…Interferons (IFNs) type‐1 (IFN α/β) and type‐II (IFN‐γ) are the most pleiotropic molecules in the intricate cytokine network. This dominance arises from three…”
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Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice by Santiago-Raber, Marie-Laure, Baccala, Roberto, Haraldsson, Katarina M, Choubey, Divaker, Stewart, Timothy A, Kono, Dwight H, Theofilopoulos, Argyrios N

“…Indirect evidence suggests that type-I interferons (IFN-alpha/beta) play a significant role in the pathogenesis of lupus. To directly examine the contribution…”
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Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery by Barnes, Michael J, Krebs, Philippe, Harris, Nathaniel, Eidenschenk, Celine, Gonzalez-Quintial, Rosana, Arnold, Carrie N, Crozat, Karine, Sovath, Sosathya, Moresco, Eva Marie, Theofilopoulos, Argyrios N, Beutler, Bruce, Hoebe, Kasper

“…Regulatory T (T(reg)) cells expressing forkhead box P3 (Foxp3) arise during thymic selection among thymocytes with modestly self-reactive T cell receptors. In…”
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Systemic autoimmunity and lymphoproliferation are associated with excess IL-7 and inhibited by IL-7Rα blockade by Gonzalez-Quintial, Rosana, Lawson, Brian R, Scatizzi, John C, Craft, Joseph, Kono, Dwight H, Baccala, Roberto, Theofilopoulos, Argyrios N

“…Lupus is characterized by disturbances in lymphocyte homeostasis, as demonstrated by the marked accumulation of activated/memory T cells. Here, we provide…”
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An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence by Crozat, Karine, Theofilopoulos, Argyrios N, Satoh, Takashi, Akira, Shizuo, Popkin, Daniel, Lawson, Brian R, Moresco, Eva Marie Y, Beutler, Bruce, Li, Xiaohong, Takeuchi, Osamu, Siggs, Owen M, Berger, Michael, Xia, Yu, Du, Xin, Krebs, Philippe, Croker, Ben A, Khovananth, Kevin

“…Quiescence must be actively maintained in cells of the immune response. Beutler and colleagues describe a new mutant mouse, elektra, with defective control of…”
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Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger by Croker, Ben A, Lawson, Brian R, Berger, Michael, Eidenschenk, Celine, Blasius, Amanda L, Moresco, Eva Marie Y, Sovath, Sosathya, Cengia, Louise, Shultz, Leonard D, Theofilopoulos, Argyrios N, Pettersson, Sven, Beutler, Bruce Alan

“…A recessive phenotype called spin (spontaneous inflammation) was induced by N-ethyl-N-nitrosourea (ENU) mutagenesis in C57BL/6J mice. Homozygotes display…”
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The Lupus-Related Lmb3 Locus Contains a Disease-Suppressing Coronin-1A Gene Mutation by Haraldsson, M. Katarina, Louis-Dit-Sully, Christine A., Lawson, Brian R., Sternik, Gabriel, Santiago-Raber, Marie-Laure, Gascoigne, Nicholas R.J., Theofilopoulos, Argyrios N., Kono, Dwight H.

“…Here, we show that a lupus-suppressing locus is caused by a nonsense mutation of the filamentous actin-inhibiting Coronin-1A gene. This mutation was associated…”
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Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice by Brandl, Katharina, Tomisato, Wataru, Li, Xiaohong, Neppl, Christina, Pirie, Elaine, Falk, Werner, Xia, Yu, Moresco, Eva Marie Y, Baccala, Roberto, Theofilopoulos, Argyrios N, Schnabl, Bernd, Beutler, Bruce

“…Using an environmentally sensitized genetic screen we identified mutations that cause inflammatory colitis in mice. The X-linked Klein-Zschocher (KLZ) mutation…”
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Critical role of transmethylation in TLR signaling and systemic lupus erythematosus by Tardif, Virginie, Manenkova, Yulia, Berger, Michael, Hoebe, Kasper, Zuo, Jian-Ping, Yuan, Chong, Kono, Dwight H, Theofilopoulos, Argyrios N, Lawson, Brian R

“…Abstract Post-translational protein modifications can play a significant role in immune cell signaling. Recently, we showed that inhibition of transmethylation…”
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TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity by Kono, Dwight H, Baccala, Roberto, Beutler, Bruce, Hoebe, Kasper, Theofilopoulos, Argyrios N

“…We formulate a two-phase paradigm of autoimmunity associated with systemic lupus erythematosus, the archetypal autoimmune disease. The initial Toll-like…”
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TLRs and IFNs: critical pieces of the autoimmunity puzzle by Theofilopoulos, Argyrios N

“…Discoveries revealing the molecular basis of innate immune responses, particularly the identification of Toll-like receptors (TLRs) as the major recognition…”
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