Search Results - "Theodorescu, D."

Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response by Nickerson, M L, Witte, N, Im, K M, Turan, S, Owens, C, Misner, K, Tsang, S X, Cai, Z, Wu, S, Dean, M, Costello, J C, Theodorescu, D

“…The utility of tumor-derived cell lines is dependent on their ability to recapitulate underlying genomic aberrations and primary tumor biology. Here, we…”
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Cytoplasmic p27 promotes epithelial–mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation by Zhao, D, Besser, A H, Wander, S A, Sun, J, Zhou, W, Wang, B, Ince, T, Durante, M A, Guo, W, Mills, G, Theodorescu, D, Slingerland, J

“…p27 restrains normal cell growth, but PI3K-dependent C-terminal phosphorylation of p27 at threonine 157 (T157) and T198 promotes cancer cell invasion. Here, we…”
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Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration by Wu, Y, Siadaty, M S, Berens, M E, Hampton, G M, Theodorescu, D

“…Cell migration is essential to cancer invasion and metastasis and is spatially and temporally integrated through transcriptionally dependent and independent…”
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The role of SPARC in the TRAMP model of prostate carcinogenesis and progression by Said, N, Frierson, H F, Chernauskas, D, Conaway, M, Motamed, K, Theodorescu, D

“…SPARC (Secreted Protein Acidic and Rich in Cysteine), is a matricellular glycoprotein that is produced by tumor and/or neighboring stroma. In human prostate…”
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Angiogenesis and prostate cancer tumor growth by Nicholson, Brian, Theodorescu, Dan

“…The initiation of new blood vessels through angiogenesis is critical to tumor growth. Tumor cells release soluble angiogenic factors that induce…”
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PKCα phosphorylation of RhoGDI2 at Ser31 disrupts interactions with Rac1 and decreases GDI activity by Griner, E M, Churchill, M E A, Brautigan, D L, Theodorescu, D

“…Rho family GTPases control a diverse range of cellular processes, and their deregulation has been implicated in human cancer. Guanine nucleotide dissociation…”
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Restoration of PTEN expression alters the sensitivity of prostate cancer cells to EGFR inhibitors by Wu, Z., Gioeli, D., Conaway, M., Weber, M. J., Theodorescu, D.

“…Introduction Prostate cancer (CaP) progression from an androgen‐dependent to an androgen‐independent state is associated with overexpression of EGFR family…”
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Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia by Wu, Y, McRoberts, K, Berr, S S, Frierson, Jr, H F, Conaway, M, Theodorescu, D

“…Most deaths from urinary bladder cancer are owing to metastatic disease. A reduction in Rho GDP Dissociation Inhibitor 2 (RhoGDI2) protein has been associated…”
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The role of PTEN in prostate cancer cell tropism to the bone micro-environment by Wu, Z, McRoberts, KS, Theodorescu, D

“…Little is known about the role of the tumor suppressor gene phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in prostate cancer bone metastasis…”
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Expression profiling of Ral-depleted bladder cancer cells identifies RREB-1 as a novel transcriptional Ral effector by OXFORD, G, SMITH, S. C, HAMPTON, G, THEODORESCU, D

“…Although the monomeric GTPases RalA and RalB have been shown to regulate a variety of transcription factors, little is known regarding the differences or…”
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Conditional expression of PTEN alters the androgen responsiveness of prostate cancer cells by Wu, Z., Conaway, M., Gioeli, D., Weber, M.J., Theodorescu, D.

“…BACKGROUND Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is lost as a function of prostate tumor androgen dependence. While the…”
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p53, bcl-2 and retinoblastoma proteins as long-term prognostic markers in localized carcinoma of the prostate by Theodorescu, D, Broder, S R, Boyd, J C, Mills, S E, Frierson, Jr, H F

“…The accumulation of p53 and bcl-2 gene products as well as the loss of the retinoblastoma (Rb) gene product have been associated with prostate cancer…”
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Why patients choose prostatectomy or brachytherapy for localized prostate cancer: results of a descriptive survey by Hall, Joshua D, Boyd, James C, Lippert, Marguerite C, Theodorescu, Dan

“…Limited data exist as to the reasons patients have for deciding among potentially curative treatment choices in clinically localized prostate cancer…”
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Outcomes of initial surveillance of invasive squamous cell carcinoma of the penis and negative nodes by Theodorescu, D, Russo, P, Zhang, Z F, Morash, C, Fair, W R

“…We determined factors predictive of inguinal nodal relapse in patients with stages T1 to 3NOMO squamous cell penile cancer treated initially with surveillance…”
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A Novel Method for Gene Expression Mapping of Metastatic Competence in Human Bladder Cancer by Wu, Z., Siadaty, M.S., Riddick, G., Frierson, H.F., Lee, J.K., Golden, W., Knuutila, S., Hampton, G.M., El-Rifai, W., Theodorescu, D.

“…Expression profiling by DNA microarray analysis has provided insights into molecular alterations that underpin cancer progression and metastasis. Although…”
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The effect of sampling more cores on the predictive accuracy of pathological grade and tumour distribution in the prostate biopsy by Makhlouf, A.A., Krupski, T.L., Kunkle, D., Theodorescu, D.

“…The technique for taking prostatic biopsies has received a major evaluation from many departments around the world in terms of the number of cores, site of…”
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The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines by Seraj, M J, Harding, M A, Gildea, J J, Welch, D R, Theodorescu, D

“…We have recently characterized a human bladder cancer cell line T24 and a more aggressive lineage related variant of it, T24T. To gain further insights, we…”
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Motivations and influences on the use of complementary medicine in patients with localized prostate cancer treated with curative intent: results of a pilot study by Hall, J.D., Bissonette, E.A., Boyd, J.C., Theodorescu, D.

“…OBJECTIVES To analyse descriptively the use of complementary medicine (CM) by patients with localized prostate cancer treated with curative intent, assessing…”
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Fibroblast Cell Interactions with Human Melanoma Cells Affect Tumor Cell Growth as a Function of Tumor Progression by Cornil, Isabelle, Theodorescu, Dan, Man, Shan, Herlyn, Meenhard, Jambrosic, J., Kerbel, R. S.

“…It is known from a variety of experimental systems that the ability of tumor cells to grow locally and metastasize can be affected by the presence of adjacent…”
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Genomancy: predicting tumour response to cancer therapy based on the oracle of genetics by Williams, P D, Lee, J K, Theodorescu, D

“…Cells are complex systems that regulate a multitude of biologic pathways involving a diverse array of molecules. Cancer can develop when these pathways become…”
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