Search Results - "Theodoratou, E"

The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis by Vaughan-Shaw, P G, O'Sullivan, F, Farrington, S M, Theodoratou, E, Campbell, H, Dunlop, M G, Zgaga, L

“…Background: Vitamin D has been linked with improved cancer outcome. This systematic review and meta-analysis investigates the relationship between cancer…”
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Low plasma vitamin D is associated with adverse colorectal cancer survival after surgical resection, independent of systemic inflammatory response by Vaughan-Shaw, P G, Zgaga, L, Ooi, L Y, Theodoratou, E, Timofeeva, M, Svinti, V, Walker, M, O'Sullivan, F, Ewing, A, Johnston, S, Din, F V N, Campbell, H, Farrington, S M, Dunlop, M G

“…We assessed the effect of surgical resection of colorectal cancer (CRC) on perioperative plasma vitamin D (25OHD) and C-reactive protein (CRP) level. We…”
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Double faecal immunochemical testing in patients with symptoms suspicious of colorectal cancer by Gerrard, A D, Maeda, Y, Miller, J, Gunn, F, Theodoratou, E, Noble, C, Porteous, L, Glancy, S, MacLean, P, Pattenden, R, Dunlop, M G, Din, F V N

“…Abstract Background Faecal immunochemical test (FIT)-directed pathways based on a single test have been implemented for symptomatic patients. However, with a…”
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MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank by Li, Xue, Meng, Xiangrui, Spiliopoulou, Athina, Timofeeva, Maria, Wei, Wei-Qi, Gifford, Aliya, Shen, Xia, He, Yazhou, Varley, Tim, McKeigue, Paul, Tzoulaki, Ioanna, Wright, Alan F, Joshi, Peter, Denny, Joshua C, Campbell, Harry, Theodoratou, Evropi

“…We aimed to investigate the role of serum uric acid (SUA) level in a broad spectrum of disease outcomes using data for 120 091 individuals from UK Biobank. We…”
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The contributions of adjusted ambient ultraviolet B radiation at place of residence and other determinants to serum 25-hydroxyvitamin D concentrations by Kelly, D., Theodoratou, E., Farrington, S.M., Fraser, R., Campbell, H., Dunlop, M.G., Zgaga, L.

“…Summary Background Solar ultraviolet B (UVB) radiation is the major source of vitamin D (vitD) for humans. Objectives To describe ambient UVB radiation at…”
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Whether vitamin D supplementation protects against colorectal cancer risk remains an open question by Vaughan-Shaw, P.G., Zgaga, L., Theodoratou, E., Blackmur, J.P., Dunlop, M.G.

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The effect of Haemophilus influenzae type b and pneumococcal conjugate vaccines on childhood pneumonia incidence, severe morbidity and mortality by Theodoratou, Evropi, Johnson, Sue, Jhass, Arnoupe, Madhi, Shabir A, Clark, Andrew, Boschi-Pinto, Cynthia, Bhopal, Sunil, Rudan, Igor, Campbell, Harry

“…Background With the aim of populating the Lives Saved Tool (LiST) with parameters of effectiveness of existing interventions, we conducted a systematic review…”
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A feasibility study of perioperative vitamin D supplementation in patients undergoing colorectal cancer resection by Vaughan-Shaw, P G, Buijs, L F, Blackmur, J P, Ewing, A, Becher, H, Theodoratou, E, Ooi, L Y, Din, F V N, Farrington, S M, Dunlop, M G

“…Vitamin D supplementation improves colorectal cancer (CRC) survival outcomes in randomized trials. The aim of this study was to test the feasibility, safety…”
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Reply to ‘Comment on ‘The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis’’ by Zgaga, L, Vaughan-Shaw, P G, O’Sullivan, F, Farrington, S M, Theodoratou, E, Campbell, H, Dunlop, M G

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A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants by Theodoratou, E, Campbell, H, Tenesa, A, Houlston, R, Webb, E, Lubbe, S, Broderick, P, Gallinger, S, Croitoru, E M, Jenkins, M A, Win, A K, Cleary, S P, Koessler, T, Pharoah, P D, Küry, S, Bézieau, S, Buecher, B, Ellis, N A, Peterlongo, P, Offit, K, Aaltonen, L A, Enholm, S, Lindblom, A, Zhou, X-L, Tomlinson, I P, Moreno, V, Blanco, I, Capellà, G, Barnetson, R, Porteous, M E, Dunlop, M G, Farrington, S M

“…Background: Defective DNA repair has a causal role in hereditary colorectal cancer (CRC). Defects in the base excision repair gene MUTYH are responsible for…”
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[NiFe]-Hydrogenase maturation endopeptidase: structure and function by Theodoratou, E, Huber, R, Böck, A

“…Hydrogenase maturation endopeptidases catalyse the terminal step in the maturation of the large subunit of [NiFe]-hydrogenases. They remove a C-terminal…”
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Common genetic variants at the MC4R locus are associated with obesity, but not with dietary energy intake or colorectal cancer in the Scottish population by Tenesa, A, Campbell, H, Theodoratou, E, Dunlop, L, Cetnarskyj, R, Farrington, S.M, Dunlop, M.G

“…Background: Common single-nucleotide polymorphism (SNP) variants around the melanocortin 4 receptor (MC4R) gene have recently been associated with obesity risk…”
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Metal insertion into NiFe-hydrogenases by Blokesch, M, Paschos, A, Theodoratou, E, Bauer, A, Hube, M, Huth, S, Böck, A

“…The synthesis and the insertion of the metallocentre of NiFe-hydrogenases is a complex process, in which seven maturation enzymes plus ATP, GTP and carbamoyl…”
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Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials by Theodoratou, Evropi, Tzoulaki, Ioanna, Zgaga, Lina, Ioannidis, John P A

“…Objective To evaluate the breadth, validity, and presence of biases of the associations of vitamin D with diverse outcomes.Design Umbrella review of the…”
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Association analyses identify 31 new risk loci for colorectal cancer susceptibility by Law, Philip J., Timofeeva, Maria, Fernandez-Rozadilla, Ceres, Broderick, Peter, Studd, James, Fernandez-Tajes, Juan, Farrington, Susan, Svinti, Victoria, Palles, Claire, Orlando, Giulia, Sud, Amit, Holroyd, Amy, Penegar, Steven, Theodoratou, Evropi, Vaughan-Shaw, Peter, Campbell, Harry, Zgaga, Lina, Hayward, Caroline, Campbell, Archie, Harris, Sarah, Deary, Ian J., Starr, John, Gatcombe, Laura, Pinna, Maria, Briggs, Sarah, Martin, Lynn, Jaeger, Emma, Sharma-Oates, Archana, East, James, Leedham, Simon, Arnold, Roland, Johnstone, Elaine, Wang, Haitao, Kerr, David, Kerr, Rachel, Maughan, Tim, Kaplan, Richard, Al-Tassan, Nada, Palin, Kimmo, Hänninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Mecklin, Jukka-Pekka, Buchanan, Daniel D., Win, Aung-Ko, Hopper, John, Jenkins, Mark E., Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steven, Duggan, David, Casey, Graham, Hoffmann, Per, Nöthen, Markus M., Jöckel, Karl-Heinz, Easton, Douglas F., Pharoah, Paul D. P., Peto, Julian, Canzian, Federico, Swerdlow, Anthony, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth, Pashayan, Nora, Harkin, Andrea, Allan, Karen, McQueen, John, Paul, James, Iveson, Timothy, Saunders, Mark, Butterbach, Katja, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Kirac, Iva, Matošević, Petar, Hofer, Philipp, Brezina, Stefanie, Gsur, Andrea, Cheadle, Jeremy P., Aaltonen, Lauri A., Tomlinson, Ian, Houlston, Richard S., Dunlop, Malcolm G.

“…Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of…”
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Gut microbiota–derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis by Li, Doudou, Lu, Ying, Yuan, Shuai, Cai, Xiaxia, He, Yuan, Chen, Jie, Wu, Qiong, He, Di, Fang, Aiping, Bo, Yacong, Song, Peige, Bogaert, Debby, Tsilidis, Kostas, Larsson, Susanna C, Yu, Huanling, Zhu, Huilian, Theodoratou, Evropi, Zhu, Yimin, Li, Xue

“…Trimethylamine-N-oxide (TMAO) is a gut microbiota–derived metabolite produced from dietary nutrients. Many studies have discovered that circulating TMAO…”
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Letter: disentangling the role of redox‐active compounds in the development of inflammatory bowel diseases—moving towards causal associations. Authors' reply by Chen, Jie, Ruan, Xixian, Yuan, Shuai, Theodoratou, Evropi, Satsangi, Jack, Li, Xue

“…LINKED CONTENT This article is linked to Chen et al papers. To view these articles, visit https://doi.org/10.1111/apt.17392 and…”
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Editorial: in search of environmental risk factors of Crohn's disease and ulcerative colitis with mendelian randomisation—authors' reply by Chen, Jie, Ruan, Xixian, Yuan, Shuai, Theodoratou, Evropi, Satsangi, Jack, Li, Xue

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Intake of Ultra-processed Foods Is Associated with an Increased Risk of Crohn’s Disease: A Cross-sectional and Prospective Analysis of 187 154 Participants in the UK Biobank by Chen, Jie, Wellens, Judith, Kalla, Rahul, Fu, Tian, Deng, Minzi, Zhang, Han, Yuan, Shuai, Wang, Xiaoyan, Theodoratou, Evropi, Li, Xue, Satsangi, Jack

“…Abstract Background and Aims Ultra-processed food [UPF] consumption has been linked to globally increasing incidence and prevalence of chronic diseases,…”
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The Contribution of Genetic Risk and Lifestyle Factors in the Development of Adult-Onset Inflammatory Bowel Disease: A Prospective Cohort Study by Sun, Yuhao, Yuan, Shuai, Chen, Xuejie, Sun, Jing, Kalla, Rahul, Yu, Lili, Wang, Lijuan, Zhou, Xuan, Kong, Xiangxing, Hesketh, Therese, Ho, Gwo-tzer, Ding, Kefeng, Dunlop, Malcolm, Larsson, Susanna C., Satsangi, Jack, Chen, Jie, Wang, Xiaoyan, Li, Xue, Theodoratou, Evropi, Giovannucci, Edward L.

“…The joint associations across genetic risk, modifiable lifestyle factors, and inflammatory bowel disease (IBD) remains unclear. Genetic susceptibility to…”
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