Search Results - "Thenoz, Morgan"

TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing by Marina, Ryan J, Sturgill, David, Bailly, Marc A, Thenoz, Morgan, Varma, Garima, Prigge, Maria F, Nanan, Kyster K, Shukla, Sanjeev, Haque, Nazmul, Oberdoerffer, Shalini

“…Intragenic 5‐methylcytosine and CTCF mediate opposing effects on pre‐mRNA splicing: CTCF promotes inclusion of weak upstream exons through RNA polymerase II…”
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HTLV-1 bZIP factor HBZ promotes cell proliferation and genetic instability by activating OncomiRs by Vernin, Céline, Thenoz, Morgan, Pinatel, Christiane, Gessain, Antoine, Gout, Olivier, Delfau-Larue, Marie-Hélène, Nazaret, Nicolas, Legras-Lachuer, Catherine, Wattel, Eric, Mortreux, Franck

“…Viruses disrupt the host cell microRNA (miRNA) network to facilitate their replication. Human T-cell leukemia virus type I (HTLV-1) replication relies on the…”
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Genetic characterization and therapeutic targeting of MYC‐rearranged T cell acute lymphoblastic leukaemia by Milani, Gloria, Matthijssens, Filip, Van Loocke, Wouter, Durinck, Kaat, Roels, Juliette, Peirs, Sofie, Thénoz, Morgan, Pieters, Tim, Reunes, Lindy, Lintermans, Beatrice, Vandamme, Niels, Lammens, Tim, Van Roy, Nadine, Van Nieuwerburgh, Filip, Deforce, Dieter, Schwab, Claire, Raimondi, Susana, Dalla Pozza, Luciano, Carroll, Andrew J., De Moerloose, Barbara, Benoit, Yves, Goossens, Steven, Berx, Geert, Harrison, Christine J., Basso, Giuseppe, Cavé, Hélène, Sutton, Rosemary, Asnafi, Vahid, Meijerink, Jules, Mullighan, Charles, Loh, Mignon, Van Vlierberghe, Pieter

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SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival by Su, Hexiu, Hu, Juncheng, Huang, Liang, Yang, Yang, Thenoz, Morgan, Kuchmiy, Anna, Hu, Yufeng, Li, Peng, Feng, Hui, Zhou, Yu, Taghon, Tom, Van Vlierberghe, Pieter, Qing, Guoliang, Chen, Zhichao, Liu, Hudan

“…T-acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with complicated heterogeneity. Although expression profiling reveals common…”
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Pre-Clinical Evaluation of the Hypomethylating Agent Decitabine for the Treatment of T-Cell Lymphoblastic Lymphoma by Provez, Lien, Putteman, Tom, Landfors, Mattias, Roels, Juliette, Reunes, Lindy, T'Sas, Sara, Van Loocke, Wouter, Lintermans, Béatrice, De Coninck, Stien, Thenoz, Morgan, Sleeckx, Wouter, Maćkowska-Maślak, Natalia, Taghon, Tom, Mansour, Marc R, Farah, Nadine, Norga, Koen, Vandenberghe, Peter, Kotecha, Rishi S, Goossens, Steven, Degerman, Sofie, De Smedt, Renate, Van Vlierberghe, Pieter

“…T-cell lymphoblastic lymphoma (T-LBL) is a rare and aggressive lymphatic cancer, often diagnosed at a young age. Patients are treated with intensive…”
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How mRNA is misspliced in acute myelogenous leukemia (AML)? by Mohamed, Aminetou Mint, Thénoz, Morgan, Solly, Françoise, Balsat, Marie, Mortreux, Franck, Wattel, Eric

“…Approximately one-third of expressed genes are misspliced in AML, opening the possibility that additional factors than splicing factor mutations might cause…”
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TET-Catalyzed 5-Carboxylcytosine Promotes CTCF Binding to Suboptimal Sequences Genome-wide by Nanan, Kyster K., Sturgill, David M., Prigge, Maria F., Thenoz, Morgan, Dillman, Allissa A., Mandler, Mariana D., Oberdoerffer, Shalini

“…The mechanisms supporting dynamic regulation of CTCF-binding sites remain poorly understood. Here we describe the TET-catalyzed 5-methylcytosine derivative,…”
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HTLV-1-infected CD4+ T-cells display alternative exon usages that culminate in adult T-cell leukemia by Thénoz, Morgan, Vernin, Céline, Mortada, Hussein, Karam, Maroun, Pinatel, Christiane, Gessain, Antoine, Webb, Thomas R, Auboeuf, Didier, Wattel, Eric, Mortreux, Franck

“…Reprogramming cellular gene transcription sustains HTLV-1 viral persistence that ultimately leads to the development of adult T-cell leukemia/lymphoma (ATLL)…”
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Chromatin Redistribution of the DEK Oncoprotein Represses hTERT Transcription in Leukemias by Karam, Maroun, Thenoz, Morgan, Capraro, Valérie, Robin, Jean-Philippe, Pinatel, Christiane, Lançon, Agnès, Galia, Perrine, Sibon, David, Thomas, Xavier, Ducastelle-Lepretre, Sophie, Nicolini, Franck, El-Hamri, Mohamed, Chelghoun, Youcef, Wattel, Eric, Mortreux, Franck

“…Abstract Although numerous factors have been found to modulate hTERT transcription, the mechanism of its repression in certain leukemias remains unknown. We…”
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Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1 by Ameur, Lamya Ben, Marie, Paul, Thenoz, Morgan, Giraud, Guillaume, Combe, Emmanuel, Claude, Jean-Baptiste, Lemaire, Sebastien, Fontrodona, Nicolas, Polveche, Hélène, Bastien, Marine, Gessain, Antoine, Wattel, Eric, Bourgeois, Cyril F., Auboeuf, Didier, Mortreux, Franck

“…Chronic NF-κB activation in inflammation and cancer has long been linked to persistent activation of NF-κB–responsive gene promoters. However, NF-κB factors…”
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HTLV-1 modulates alternative splicing in CD4+ T cells in vivo by Thenoz, Morgan, Vernin, Céline, Pinatel, Christiane, Nazaret, Nicolas, Lachuer, Joel, Auboeuf, Didier, Wattel, Eric, Mortreux, Franck

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Tax alters telomerase activity through both quantitative and qualitative hTERT transcriptional dysregulations by Karam, Maroun, Thenoz, Morgan, Zane, Linda, Vernin, Céline, Lançon, Agnes, Pinatel, Christiane, Wattel, Eric, Mortreux, Franck

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Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia by Roels, Juliette, Thénoz, Morgan, Szarzyńska, Bronisława, Landfors, Mattias, De Coninck, Stien, Demoen, Lisa, Provez, Lien, Kuchmiy, Anna, Strubbe, Steven, Reunes, Lindy, Pieters, Tim, Matthijssens, Filip, Van Loocke, Wouter, Erarslan-Uysal, Büşra, Richter-Pechańska, Paulina, Declerck, Ken, Lammens, Tim, De Moerloose, Barbara, Deforce, Dieter, Van Nieuwerburgh, Filip, Cheung, Laurence C, Kotecha, Rishi S, Mansour, Marc R, Ghesquière, Bart, Van Camp, Guy, Berghe, Wim Vanden, Kowalczyk, Jerzy R, Szczepański, Tomasz, Davé, Utpal P, Kulozik, Andreas E, Goossens, Steven, Curtis, David J, Taghon, Tom, Dawidowska, Małgorzata, Degerman, Sofie, Van Vlierberghe, Pieter

“…Cancer cells display DNA hypermethylation at specific CpG islands in comparison to their normal healthy counterparts, but the mechanism that drives this…”
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Oncogene- and drug resistance-associated alternative exon usage in acute myeloid leukemia (AML) by Mohamed, Aminetou Mint, Balsat, Marie, Thenoz, Morgan, Koering, Catherine, Payen-Gay, Lea, Cheok, Meyling, Mortada, Hussein, Auboeuf, Didier, Pinatel, Christiane, El-Hamri, Mohamed, Dumontet, Charles, Cros, Emeline, Flandrin-Gresta, Pascale, Nibourel, Olivier, Preudhomme, Claude, Michallet, Mauricette, Thomas, Xavier, Nicolini, Franck, Solly, Françoise, Guyotat, Denis, Campos, Lydia, Wattel, Eric, Mortreux, Franck

“…In addition to spliceosome gene mutations, oncogene expression and drug resistance in AML might influence exon expression. We performed exon-array analysis and…”
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DEK and WT1 Affect Alternative Splicing of Genes Involved in Hematopoietic Cell Lineage and Resistance to Chemotherapy in Acute Myeloid Leukemia Cells by Mohamed, Aminetou Mint, Thenoz, Morgan, Koering, Catherine, Mallinjoud, Pierre, Auboeuf, Didier, Solly, Francoise, Cheok, Meyling, Nibourel, Olivier, Preudhomme, Claude, Wattel, Eric, Mortreux, Franck

“…Abstract 2392 In humans, the majority of all protein-coding transcripts contain introns that are removed by mRNA splicing carried out by spliceosomes…”
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Alternative splicing signatures discriminate ATL cells from untransformed CD4+ counterparts deriving from HTLV-1 infected individuals by Thenoz, Morgan, Vernin, Céline, Pinatel, Christiane, Nazaret, Nicolas, Lachuer, Joel, Gessain, Antoine, Auboeuf, Didier, Wattel, Eric, Mortreux, Franck

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Tax promotes the expression of the alternative spliced isoform CD44v10 by slowing down the elongating RNA polymerase II by Thenoz, Morgan, Vernin, Céline, Pinatel, Christiane, Nazaret, Nicolas, Lachuer, Joel, Gessain, Antoine, Auboeuf, Didier, Wattel, Eric, Mortreux, Franck

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Skipping of ATP-Binding Cassette Transporter A3 Exon 19 in AML Cells Is an Independent Prognostic Factor in Patients with Normal Cytogenetics by Mohamed, Aminetou Mint, Thenoz, Morgan, Payen-Gay, Lea, Maucort-Boulch, Delphine, Mortada, Hussein, Auboeuf, Didier, Koering, Catherine, Cheok, Meyling, Nibourel, Olivier, Preudhomme, Claude, El-Hamri, Mohamed, Thomas, Xavier, Nicolini, Franck E., Tigaud, Isabelle, Cros, Emeline, Dumontet, Charles, Campos, Lydia, Solly, Francoise, Guyotat, Denis, Flandrin-Gresta, Pascale, Mortreux, Franck, Wattel, Eric

“…ATP binding cassette (ABC) transporters are a superfamily of highly conserved membrane proteins that transport a wide variety of substrates across cell…”
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Chromatin Redistribution of the DEK Oncoprotein Represses hTERT Transcription in Leukemias12 by Karam, Maroun, Thenoz, Morgan, Capraro, Valérie, Robin, Jean-Philippe, Pinatel, Christiane, Lancon, Agnès, Galia, Perrine, Sibon, David, Thomas, Xavier, Ducastelle-Lepretre, Sophie, Nicolini, Franck, El-Hamri, Mohamed, Chelghoun, Youcef, Wattel, Eric, Mortreux, Franck

“…Although numerous factors have been found to modulate hTERT transcription, the mechanism of its repression in certain leukemias remains unknown. We show here…”
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3067 – THE ROLE OF TET2 IN (PRE-)LEUKEMIC T-ALL: TET2 TO THE RESCUE? by De Coninck, Stien, Roels, Juliette, Thénoz, Morgan, Lintermans, Béatrice, Goossens, Steven, Van Vlierberghe, Pieter

“…T-cell acute lymphoblastic leukemia (T-ALL) accounts for 15% of pediatric and 25% of adult ALL patients. Therapy has been intensified over the last decades,…”
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