Search Results - "Then, R L"

In Vitro and In Vivo Properties of Ro 63-9141, a Novel Broad-Spectrum Cephalosporin with Activity against Methicillin-Resistant Staphylococci by HEBEISEN, Paul, HEINZE-KRAUSS, Ingrid, ANGEHRN, Peter, HOHL, Peter, PAGE, Malcolm G. P, THEN, Rudolf L

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Antimicrobial Dihydrofolate Reductase Inhibitors - Achievements and Future Options: Review by Then, R.L.

“…Despite all progress made in the fight against infections caused by bacteria, fungi, protozoa or viruses, there is a need for more and new active agents…”
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Antibacterial activities of epiroprim, a new dihydrofolate reductase inhibitor, alone and in combination with dapsone by LOCHER, H. H, SCHLUNEGGER, H, HARTMAN, P. G, ANGEHRN, P, THEN, R. L

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Cloning and characterization of a novel, plasmid-encoded trimethoprim-resistant dihydrofolate reductase from Staphylococcus haemolyticus MUR313 by DALE, G. E, LANGEN, H, PAGE, M. G. P, THEN, R. L, STÜBER, D

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Characterization of the gene for the chromosomal dihydrofolate reductase (DHFR) of Staphylococcus epidermidis ATCC 14990: the origin of the trimethoprim-resistant S1 DHFR from Staphylococcus aureus? by Dale, G E, Broger, C, Hartman, P G, Langen, H, Page, M G, Then, R L, Stüber, D

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History and future of antimicrobial diaminopyrimidines by Then, R L

“…Numerous pyrimidine and purine analogs were synthesized in the late forties in G.H. Hitchings' group as potential nucleic acid antagonists. Several key…”
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Activity of epiroprim (Ro 11-8958), a dihydrofolate reductase inhibitor, alone and in combination with dapsone against Toxoplasma gondii by CHANG, H. R, ARSENIJEVIC, D, COMTE, R, POLAK, A, THEN, R. L, PECHERE, J.-C

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Characterization of the gene for chromosomal trimethoprim-sensitive dihydrofolate reductase of Staphylococcus aureus ATCC 25923 by Dale, G E, Then, R L, Stüber, D

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Trapping of nonhydrolyzable cephalosporins by cephalosporinases in Enterobacter cloacae and Pseudomonas aeruginosa as a possible resistance mechanism by Then, R L, Angehrn, P

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Multiply resistant mutants of Enterobacter cloacae selected by beta-lactam antibiotics by THEN, R. L, ANGEHRN, P

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A pilot study on the efficacy of epiroprim against developmental stages of Toxoplasma gondii and Pneumocystis carinii in animal models by MEHLHORN, H, DANKERT, W, HARTMAN, P. G, THEN, R. L

“…The new bacteriocidal drug epiroprim (Ro-11-8958) was tested (alone or in combination with dapsone) on its efficacy against Toxoplasma gondii and Pneumocystis…”
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In vitro and in vivo evaluation of Ro 09-1428, a new parenteral cephalosporin with high antipseudomonal activity by ARISAWA, M, SEKINE, Y, SHIMIZU, S, TAKANO, H, ANGEHRN, P, THEN, R. L

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Ability of newer beta-lactam antibiotics to induce beta-lactamase production in Enterobacter cloacae by Then, R L

“…The beta-lactamase inducing properties of various new beta-lactam antibiotics in two isogenic strains of Enterobacter cloacae were investigated. Beta-lactamase…”
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Permeability and penicillin-binding protein alterations in Salmonella muenchen: stepwise resistance acquired during beta-lactam therapy by BELLIDO, F, VLADOIANU, I. R, AUCKENTHALER, R, SUTER, S, WACKER, P, THEN, R. L, PECHERE, J. C

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Ro 13-9904, a long-acting broad-spectrum cephalosporin: in vitro and in vivo studies by Angehrn, P, Probst, P J, Reiner, R, Then, R L

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Structure and function of the dihydropteroate synthase from staphylococcus aureus by Hampele, Isabelle C, D’Arcy, Allan, Dale, Glenn E, Kostrewa, Dirk, Nielsen, Jørgen, Oefner, Christian, Page, Malcolm G.P, Schönfeld, Hans-Joachim, Stüber, Dietrich, Then, Rudolf L

“…The gene encoding the dihydropteroate synthase of staphylococcus aureus has been cloned, sequenced and expressed in Escherichia coli. The protein has been…”
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Identical genes for trimethoprim-resistant dihydrofolate reductase from Staphylococcus aureus in Australia and Central Europe by Burdeska, Alexander, Ott, Michael, Bannwarth, Willi, Then, Rudolf L.

“…The nucleotide sequence of a 1.25 kb BglII/ EcoRI fragment from the 34 kb trimethoprim (Tp)-resistant plasmid pABU1 of Staphylococcus aureus 157/4696, isolated…”
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Selective inhibition of dihydrofolate reductase from problem human pathogens by Then, R L, Hartman, P G, Kompis, I, Santi, D

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A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance by Dale, G E, Broger, C, D'Arcy, A, Hartman, P G, DeHoogt, R, Jolidon, S, Kompis, I, Labhardt, A M, Langen, H, Locher, H, Page, M G, Stüber, D, Then, R L, Wipf, B, Oefner, C

“…A single amino acid substitution, Phe98 to Tyr98, in dihydrofolate reductase (DHFR) is the molecular origin of trimethoprim (TMP) resistance in Staphylococcus…”
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Interaction of Ro 17-2301 (AMA-1080) with beta-lactamases by Then, R L

“…Against a variety of beta-lactamases tested, mostly of chromosomal origin, Ro 17-2301 (AMA-1080) proved to be more stable than the new cephalosporins and thus…”
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