Circulating soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor during pregnancy in normotensive women in KwaZulu-Natal, South Africa
Abstract Background: Based on the increased pre-eclampsia and HIV antenatal incidence in South Africa, we determined the angiogenic profiles due to its mechanistic link in preeclampsia development, throughout uncomplicated pregnancies in HIV positive and negative women. Objective: To determine the a...
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| Published in: | African health sciences Vol. 19; no. 2; pp. 1821 - 1832 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Uganda
Makerere University Medical School
01-06-2019
Makerere Medical School |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Abstract Background: Based on the increased pre-eclampsia and HIV
antenatal incidence in South Africa, we determined the angiogenic
profiles due to its mechanistic link in preeclampsia development,
throughout uncomplicated pregnancies in HIV positive and negative
women. Objective: To determine the angiogenic profiles throughout
uncomplicated pregnancies in HIV positive and HIV negative women. We
explored possible correlations between angiogenic serum levels and
selected maternal characteristics (HIV status, gestational age,
maternal factors, and pregnancy outcomes). Method: This study was
conducted at a primary health care facility in Durban, South Africa.
Forty-six pregnant women aged 18-45 years, were enrolled at 10-20,
22-30 and 32-38 weeks' gestation, respectively through convenient
sampling. Serum samples were collected and quantitatively evaluated
using ELISAs. Clinical and epidemiological data were analysed using
STATA (version 14). A probability level of p < 0.05 was considered
statistically significant. Results: Of those enrolled, 28.3% were
nulliparous, 82% were HIV positive and none developed pre-eclampsia.
Systolic and diastolic blood pressure increased slightly throughout
pregnancy. Fluctuating angiogenic and anti-angiogenic levels were
demonstrated during pregnancy. Conclusion: This study contributes to
the current angiogenic knowledge in normotensive pregnancies, and may
assist as a reference range against which these factors may be compared
in HIV complicated pregnancies. Keywords: sFlt-1, PlGF, sEng,
pregnancy, HIV. DOI: https://dx.doi.org/10.4314/ahs.v19i2.4 Cite as:
Ogunlola M, Reddy P, Sibiya MN, O'Connor L, Borg D, Haffejee F,
Ghuman S, Ngxongo T, Govender N. Circulating soluble fmslike tyrosine
kinase-1, soluble endoglin and placental growth factor during pregnancy
in normotensive women in KwaZulu-Natal, South Africa. Afri Health
Sci.2019;19(2): 1821-1832. https://dx.doi.org/10.4314/ahs.v19i2.4 |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 muhaogunlola@yahoo.com; Contact number: 0742249999- PoovieR@dut.ac.za; Contact number: 031 373-2808 nokuthulas@dut.ac.za; Contact number: 031 373-2704- lauraw@dut.ac.za; Contact number:031 373-2923-dorindab@dut.ac.za; Contact number: 031 373-2390- firozah@dut.ac.za; Contact number: 031 373-2395-shanazg@dut.ac.za; Contact number:031 373-2807- thembelihlen@dut.ac.za; Contact number:031 373-2609-nalinip@dut.ac.za; Contact number: 031 373-2796 Emails |
| ISSN: | 1680-6905 1729-0503 1680-6905 |
| DOI: | 10.4314/ahs.v19i2.4 |