Search Results - "Thelen, Karin M."

Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin by Thelen, Karin M, Rentsch, Katharina M, Gutteck, Ursula, Heverin, Maura, Olin, Maria, Andersson, Ulla, von Eckardstein, Arnold, Björkhem, Ingemar, Lütjohann, Dieter

“…On a global scale, there is an increasing tendency for a more aggressive treatment of hypercholesterolemia. Minor effects of statins on brain cholesterol…”
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High-dose statins and skeletal muscle metabolism in humans: A randomized, controlled trial by Päivä, Hannu, Thelen, Karin M., Van Coster, Rudy, Smet, Joél, De Paepe, Boel, Mattila, Kari M., Laakso, Juha, Lehtimäki, Terho, Bergmann, Klaus, Lütjohann, Dieter, Laaksonen, Reijo

“…Background Myopathy, probably caused by 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase inhibition in skeletal muscle, rarely occurs in patients taking…”
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The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Aβ generation in vivo by Crameri, Arames, Biondi, Elisa, Kuehnle, Katrin, Lütjohann, Dieter, Thelen, Karin M, Perga, Simona, Dotti, Carlos G, Nitsch, Roger M, Ledesma, Maria Dolores, Mohajeri, M Hasan

“…The cholesterol‐synthesizing enzyme seladin‐1, encoded by the Dhcr24 gene, is a flavin adenine dinucleotide‐dependent oxidoreductase and regulates responses to…”
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Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis by Tamboli, Irfan Y, Prager, Kai, Thal, Dietmar R, Thelen, Karin M, Dewachter, Ilse, Pietrzik, Claus U, St George-Hyslop, Peter, Sisodia, Sangram S, De Strooper, Bart, Heneka, Michael T, Filippov, Mikhail A, Müller, Ulrike, van Leuven, Fred, Lütjohann, Dieter, Walter, Jochen

“…Presenilins (PSs) are components of the gamma-secretase complex that mediates intramembranous cleavage of type I membrane proteins. We show that…”
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Simvastatin prolongs survival times in prion infections of the central nervous system by Mok, Simon Wing Fai, Thelen, Karin M., Riemer, Constanze, Bamme, Theresa, Gültner, Sandra, Lütjohann, Dieter, Baier, Michael

“…Prion diseases are fatal and at present there are neither cures nor palliative therapies known/available, which delay disease onset or progression…”
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High-Dose Statin Treatment Does Not Alter Plasma Marker for Brain Cholesterol Metabolism in Patients With Moderately Elevated Plasma Cholesterol Levels by Thelen, Karin M., Laaksonen, Reijo, Päivä, Hannu, Lehtimäki, Terho, Lütjohann, Dieter

“…Statins inhibit endogenous cholesterol synthesis, up‐regulate low‐density lipoprotein (LDL) receptor expression in mammalian liver cells, and thus decrease…”
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Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels by Jansen, Paula J, Lütjohann, Dieter, Thelen, Karin M, von Bergmann, Klaus, van Leuven, Fred, Ramaekers, Frans C S, Monique, Monique

“…Apolipoprotein E (apoE) is a regulator of peripheral cholesterol homeostasis, and the apoE-isoform E4 is a major risk factor for the development of Alzheimer's…”
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Genetic variant of the SREBF-1 gene is significantly related to cholesterol synthesis in man by Laaksonen, Reijo, Thelen, Karin M, Päivä, Hannu, Matinheikki, Jussi, Vesalainen, Risto, Janatuinen, Tuula, Knuuti, Juhani, Rontu, Riikka, Bergmann, Klaus von, Lütjohann, Dieter, Lehtimäki, Terho

“…Sterol regulatory element binding proteins-1 and -2 (SREBPs) are transcription factors controlling lipid homeostasis in human cells. The G-allele carriers of…”
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Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice by Kuehnle, Katrin, Ledesma, Maria D, Kalvodova, Lucie, Smith, Alicia E, Crameri, Arames, Skaanes-Brunner, Fabienne, Thelen, Karin M, Kulic, Luka, Lütjohann, Dieter, Heppner, Frank L, Nitsch, Roger M, Mohajeri, M Hasan

“…Cholesterol is a prominent modulator of the integrity and functional activity of physiological membranes and the most abundant sterol in the mammalian brain…”
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Altered cholesterol metabolism in APP695-transfected neuroblastoma cells by Wirths, Oliver, Thelen, Karin M, Lütjohann, Dieter, Falkai, Peter, Bayer, Thomas A

“…Abstract Cholesterol has been implicated to play an important role in the generation of Aβ peptides, which are the main component of β-amyloid plaques in the…”
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Effect of pravastatin on plasma sterols and oxysterols in men by THELEN, Karin M, LUTJOHANN, Dieter, VESALAINEN, Risto, JANATUINEN, Tuula, KNUUTI, Juhani, VON BERGMANN, Klaus, LEHTIMÄKI, Terho, LAAKSONEN, Reijo

“…The HMG-CoA reductase inhibitors, or statins, are well established in the prevention and treatment of coronary artery disease, mainly by lowering low-density…”
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Age-dependent Increase in Desmosterol Restores DRM Formation and Membrane-related Functions in Cholesterol-free DHCR24−/− Mice by Kuehnle, Katrin, Ledesma, Maria D., Kalvodova, Lucie, Smith, Alicia E., Crameri, Arames, Skaanes-Brunner, Fabienne, Thelen, Karin M., Kulic, Luka, Lütjohann, Dieter, Heppner, Frank L., Nitsch, Roger M., Mohajeri, M. Hasan

“…The online version of the original article can be found under doi: 10.1007/s11064-008-9893-4…”
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RETRACTED ARTICLE: Age-dependent Increase in Desmosterol Restores DRM Formation and Membrane-related Functions in Cholesterol-free DHCR24−/− Mice by Kuehnle, Katrin, Ledesma, Maria D., Kalvodova, Lucie, Smith, Alicia E., Crameri, Arames, Skaanes-Brunner, Fabienne, Thelen, Karin M., Kulic, Luka, Lütjohann, Dieter, Heppner, Frank L., Nitsch, Roger M., Mohajeri, M. Hasan

“…Cholesterol is a prominent modulator of the integrity and functional activity of physiological membranes and the most abundant sterol in the mammalian brain…”
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The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and A[beta] generation in vivo by Crameri, Arames, Biondi, Elisa, Kuehnle, Katrin, Lütjohann, Dieter, Thelen, Karin M, Perga, Simona, Dotti, Carlos G, Nitsch, Roger M, Ledesma, Maria Dolores, Mohajeri, M Hasan

“…The cholesterol-synthesizing enzyme seladin-1, encoded by the Dhcr24 gene, is a flavin adenine dinucleotide-dependent oxidoreductase and regulates responses to…”
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The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo by Crameri, Arames, Biondi, Elisa, Kuehnle, Katrin, Lütjohann, Dieter, Thelen, Karin M, Perga, Simona, Dotti, Carlos G, Nitsch, Roger M, Ledesma, Maria Dolores, Mohajeri, M Hasan

“…The cholesterol-synthesizing enzyme seladin-1, encoded by the Dhcr24 gene, is a flavin adenine dinucleotide-dependent oxidoreductase and regulates responses to…”
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Loss of γ-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis by Lütjohann, Dieter, Tamboli, Irfan Y., Prager, Kai, Thal, Dietmar R., Thelen, Karin M., Dewachter, Ilse, Pietrzik, Claus U., St. George-Hyslop, Peter, Sisodia, Sangram S., Müller, Ulrike, van Leuven, Fred, Walter, Jochen

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P4-386 The effect of simvastatin treatmnt the processing of the amyloid precursor protein in patients with Alzheimer's disease by Hoglund, Kina, Thelen, Karin M., Syversen, Steinar, Sjogren, Magnus, von Bergmann, Klas, Wallin, Anders, Vanmechelen, Eugeen, Vanderstichele, Hugo, Luetjohann, Dieter, Blennow, Kaj

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Loss of {gamma}-Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis by Tamboli, Irfan Y, Prager, Kai, Thal, Dietmar R, Thelen, Karin M, Dewachter, Ilse, Pietrzik, Claus U, St. George-Hyslop, Peter, Sisodia, Sangram S, De Strooper, Bart, Heneka, Michael T, Filippov, Mikhail A, Muller, Ulrike, van Leuven, Fred, Lutjohann, Dieter, Walter, Jochen

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