Search Results - "Theilgaard‐Mönch, Kim"

TET2 deficiency cooperates with CBFB‐MYH11 to induce acute myeloid leukaemia and represents an early leukaemogenic event by Reckzeh, Kristian, Estruch, Montserrat, Ali, Mina, Søgaard Helbo, Alexandra, Mosbech, Anna, Jae Won, Kyoung, Rücker, Frank, Döhner, Konstanze, Theilgaard‐Mönch, Kim

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Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients by Rapin, Nicolas, Bagger, Frederik Otzen, Jendholm, Johan, Mora-Jensen, Helena, Krogh, Anders, Kohlmann, Alexander, Thiede, Christian, Borregaard, Niels, Bullinger, Lars, Winther, Ole, Theilgaard-Mönch, Kim, Porse, Bo T.

“…Gene expression profiling has been used extensively to characterize cancer, identify novel subtypes, and improve patient stratification. However, it has…”
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Effects of chemotherapy dose reductions in overweight patients with acute myeloid leukaemia: A Danish nationwide cohort study by Kristensen, Daniel Tuyet, Nielsen, Lars Børty, Jakobsen, Lasse Hjort Kyneb, Kristensen, Tove‐Christina Choe, Jepsen, Lene Østergaard, Schöllkopf, Claudia, Theilgaard‐Mönch, Kim, El‐Galaly, Tarec Christoffer, Roug, Anne Stidsholt, Severinsen, Marianne Tang

“…Summary Overweight patients with cancer are frequently reduced in chemotherapy dose due to toxicity concerns, although previous studies have indicated that…”
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Temporal changes in survival among adult patients with acute myeloid leukaemia in the period 2000–2016: a Danish population‐based study by Hjort Jakobsen, Lasse, Stidsholt Roug, Anne, Kiesbye Øvlisen, Andreas, Werenberg Marcher, Claus, Beier Ommen, Hans, Theilgaard‐Mönch, Kim, Møller, Peter, Schöllkopf, Claudia, Kristensen, Daniel, Maria Henriette Naur, Therese, Bøgsted, Martin, Christoffer El‐Galaly, Tarec, Tang Severinsen, Marianne

“…Summary In the present study, we quantify the progress in overall survival (OS) during the period 2000–2016 among Danish patients with acute myeloid leukaemia…”
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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells by Bracken, Adrian P, Kleine-Kohlbrecher, Daniela, Dietrich, Nikolaj, Pasini, Diego, Gargiulo, Gaetano, Beekman, Chantal, Theilgaard-Mönch, Kim, Minucci, Saverio, Porse, Bo T, Marine, Jean-Christophe, Hansen, Klaus H, Helin, Kristian

“…The p16INK4A and p14ARF proteins, encoded by the INK4A-ARF locus, are key regulators of cellular senescence, yet the mechanisms triggering their up-regulation…”
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Trends in survival and cure after allogeneic haematopoietic cell transplantation for acute myeloid leukaemia from 2000 to 2020: A Danish population‐based cohort study by Gjærde, Lars K., Jakobsen, Lasse H., Juhl‐Christensen, Caroline, Olesen, Gitte, Petruskevicius, Irma, Severinsen, Marianne T., Marcher, Claus W., Theilgaard‐Mönch, Kim, Andersen, Niels S., Friis, Lone S., Kornblit, Brian, Petersen, Søren L., Schjødt, Ida, Sengeløv, Henrik

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The prognostic effect of smoking status on intensively treated acute myeloid leukaemia – A Danish nationwide cohort study by Kristensen, Daniel, Nielsen, Lars B., Roug, Anne S., Kristensen, Tove‐Christina C., El‐Galaly, Tarec C., Nørgaard, Jan M., Marcher, Claus W., Schöllkopf, Claudia, Theilgaard‐Mönch, Kim, Severinsen, Marianne T.

“…Summary With rising life expectancy, the importance of patient‐related prognostic factors and how to integrate such data into clinical decision‐making becomes…”
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Endomucin marks quiescent long-term multi-lineage repopulating hematopoietic stem cells and is essential for their transendothelial migration by Engelhard, Sophia, Estruch, Montserrat, Qin, Shuyu, Engelhard, Christoph A., Rodriguez-Gonzalez, Francisco G., Drilsvik, Martine, Martin-Gonzalez, Javier, Lu, Jeng-Wei, Bryder, David, Nerlov, Claus, Weischenfeldt, Joachim, Reckzeh, Kristian, Theilgaard-Mönch, Kim

“…Endomucin (EMCN) currently represents the only hematopoietic stem cell (HSC) marker expressed by both murine and human HSCs. Here, we report that EMCN+…”
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Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils by Jacobsen, Lars C., Theilgaard-Mönch, Kim, Christensen, Erik I., Borregaard, Niels

“…Arginase 1 (ARG1) metabolizes arginine, thus reducing the availability of arginine as a substrate for nitric oxide synthase (NOS). The decreased production of…”
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Wound Healing and Expression of Antimicrobial Peptides/Polypeptides in Human Keratinocytes, a Consequence of Common Growth Factors by Sorensen, Ole E, Cowland, Jack B, Theilgaard-Monch, Kim, Liu, Lide, Ganz, Tomas, Borregaard, Niels

“…In addition to acting as a physical barrier against microorganisms, the skin produces antimicrobial peptides and proteins. After wounding, growth factors are…”
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Differential expression of granulopoiesis related genes in neutrophil subsets distinguished by membrane expression of CD177 by Hu, Nan, Mora-Jensen, Helena, Theilgaard-Mönch, Kim, Doornbos-van der Meer, Berber, Huitema, Minke G, Stegeman, Coen A, Heeringa, Peter, Kallenberg, Cees G M, Westra, Johanna

“…Differential gene expression in CD177+ and CD177- neutrophils was investigated, in order to detect possible differences in neutrophil function which could be…”
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The transcriptional program of terminal granulocytic differentiation by Theilgaard-Mönch, Kim, Jacobsen, Lars Christian, Borup, Rehannah, Rasmussen, Thomas, Bjerregaard, Malene Digmann, Nielsen, Finn Cilius, Cowland, Jack Bernard, Borregaard, Niels

“…To characterize the transcriptional program that governs terminal granulocytic differentiation in vivo, we performed comprehensive microarray analyses of human…”
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HemaExplorer: a Web server for easy and fast visualization of gene expression in normal and malignant hematopoiesis by Bagger, Frederik Otzen, Rapin, Nicolas, Theilgaard-Mönch, Kim, Kaczkowski, Bogumil, Jendholm, Johan, Winther, Ole, Porse, Bo

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Dose-reduction trials in oncology — aiming for less toxicity and better quality of life at lower costs by Theilgaard-Mönch, Kim, Ehlers, Lars Holger

“…Projected increases of cancer-attributable health-care costs, accompanied by staff shortages, will impose future economic and operational challenges on…”
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Technical Advance: Immunophenotypical characterization of human neutrophil differentiation by Mora‐Jensen, Helena, Jendholm, Johan, Fossum, Anna, Porse, Bo, Borregaard, Niels, Theilgaard‐Mönch, Kim

“…A novel protocol for studying human neutrophil differentiation in vivo as an alternative to models based on in vitro differentiation of cell lines. The current…”
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Gut microbiota sustains hematopoiesis by Theilgaard-Mönch, Kim

“…In this issue of Blood, Josefsdottir et al provide substantial evidence that commensal gut microbes regulate and sustain normal steady-state hematopoiesis…”
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The secretory leukocyte protease inhibitor (SLPI) and the secondary granule protein lactoferrin are synthesized in myelocytes, colocalize in subcellular fractions of neutrophils, and are coreleased by activated neutrophils by Jacobsen, Lars C., Sørensen, Ole E., Cowland, Jack B., Borregaard, Niels, Theilgaard‐Mönch, Kim

“…The secretory leukocyte protease inhibitor (SLPI) re‐establishes homeostasis at sites of infection by virtue of its ability to exert antimicrobial activity, to…”
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The EHA Research Roadmap: Normal Hematopoiesis by Jaffredo, Thierry, Balduini, Alessandra, Bigas, Anna, Bernardi, Rosa, Bonnet, Dominique, Canque, Bruno, Charbord, Pierre, Cumano, Anna, Delwel, Ruud, Durand, Charles, Fibbe, Willem, Forrester, Lesley, Franceschi, Lucia, Ghevaert, Cedric, Gjertsen, Bjørn, Gottgens, Berthold, Graf, Thomas, Heidenreich, Olaf, Hermine, Olivier, Higgs, Douglas, Kleanthous, Marina, Klump, Hannes, Kouskoff, Valerie, Krause, Daniela, Lacaud, George, Celso, Cristina Lo, Martens, Joost H.A., Méndez‐Ferrer, Simón, Menendez, Pablo, Oostendorp, Robert, Philipsen, Sjaak, Porse, Bo, Raaijmakers, Marc, Robin, Catherine, Stunnenberg, Henk, Theilgaard‐Mönch, Kim, Touw, Ivo, Vainchenker, William, Corrons, Joan‐Lluis Vives, Yvernogeau, Laurent, Schuringa, Jan Jacob

“…In 2016, the European Hematology Association (EHA) published the EHA Roadmap for European Hematology Research1 aiming to highlight achievements in the…”
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Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin by Reckzeh, Kristian, Kizilkaya, Hüsün, Helbo, Alexandra Søgaard, Alrich, Montserrat Estruch, Deslauriers, André Gundersen, Grover, Amit, Rapin, Nicolas, Asmar, Fazila, Grønbæk, Kirsten, Porse, Bo, Borregaard, Niels, Vestweber, Dietmar, Nerlov, Claus, Theilgaard-Mönch, Kim

“…•EMCN is a novel marker of human HSCs.•EMCN is a more specific marker of HSCs than CD34 as it can discriminate HSCs from lineage-committed HPCs. [Display…”
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Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency by Hasemann, Marie S, Schuster, Mikkel B, Frank, Anne-Katrine, Theilgaard-Mönch, Kim, Pedersen, Thomas Å, Nerlov, Claus, Porse, Bo T

“…Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate…”
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