Search Results - "Theißen, Jessica"

Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma by Powers, John T., Tsanov, Kaloyan M., Pearson, Daniel S., Roels, Frederik, Spina, Catherine S., Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theißen, Jessica, Tu, Ho-Chou, Han, Areum, Kurek, Kyle C., LaPier, Grace S., Osborne, Jihan K., Ross, Samantha J., Cesana, Marcella, Collins, James J., Berthold, Frank, Daley, George Q.

“…Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN . MYCN is itself a target of let-7 , a tumour suppressor family of microRNAs…”
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Mutational dynamics between primary and relapse neuroblastomas by Schramm, Alexander, Köster, Johannes, Assenov, Yassen, Althoff, Kristina, Peifer, Martin, Mahlow, Ellen, Odersky, Andrea, Beisser, Daniela, Ernst, Corinna, Henssen, Anton G, Stephan, Harald, Schröder, Christopher, Heukamp, Lukas, Engesser, Anne, Kahlert, Yvonne, Theissen, Jessica, Hero, Barbara, Roels, Frederik, Altmüller, Janine, Nürnberg, Peter, Astrahantseff, Kathy, Gloeckner, Christian, De Preter, Katleen, Plass, Christoph, Lee, Sangkyun, Lode, Holger N, Henrich, Kai-Oliver, Gartlgruber, Moritz, Speleman, Frank, Schmezer, Peter, Westermann, Frank, Rahmann, Sven, Fischer, Matthias, Eggert, Angelika, Schulte, Johannes H

“…Alexander Schramm, Johannes Schulte and colleagues characterize 16 paired samples from patients with neuroblastoma at diagnosis and relapse using whole-exome…”
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Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients by Depuydt, Pauline, Boeva, Valentina, Hocking, Toby D, Cannoodt, Robrecht, Ambros, Inge M, Ambros, Peter F, Asgharzadeh, Shahab, Attiyeh, Edward F, Combaret, Valérie, Defferrari, Raffaella, Fischer, Matthias, Hero, Barbara, Hogarty, Michael D, Irwin, Meredith S, Koster, Jan, Kreissman, Susan, Ladenstein, Ruth, Lapouble, Eve, Laureys, Geneviève, London, Wendy B, Mazzocco, Katia, Nakagawara, Akira, Noguera, Rosa, Ohira, Miki, Park, Julie R, Pötschger, Ulrike, Theissen, Jessica, Tonini, Gian Paolo, Valteau-Couanet, Dominique, Varesio, Luigi, Versteeg, Rogier, Speleman, Frank, Maris, John M, Schleiermacher, Gudrun, De Preter, Katleen

“…Neuroblastoma is characterized by substantial clinical heterogeneity. Despite intensive treatment, the survival rates of high-risk neuroblastoma patients are…”
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Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers by Oberthuer, André, Juraeva, Dilafruz, Hero, Barbara, Volland, Ruth, Sterz, Carolina, Schmidt, Rene, Faldum, Andreas, Kahlert, Yvonne, Engesser, Anne, Asgharzadeh, Shahab, Seeger, Robert, Ohira, Miki, Nakagawara, Akira, Scaruffi, Paola, Tonini, Gian Paolo, Janoueix-Lerosey, Isabelle, Delattre, Olivier, Schleiermacher, Gudrun, Vandesompele, Jo, Speleman, Frank, Noguera, Rosa, Piqueras, Marta, Bénard, Jean, Valent, Alexander, Avigad, Smadar, Yaniv, Isaac, Grundy, Richard G, Ortmann, Monika, Shao, Chunxuan, Schwab, Manfred, Eils, Roland, Simon, Thorsten, Theissen, Jessica, Berthold, Frank, Westermann, Frank, Brors, Benedikt, Fischer, Matthias

“…To optimize neuroblastoma treatment stratification, we aimed at developing a novel risk estimation system by integrating gene expression-based classification…”
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FOXP1 inhibits cell growth and attenuates tumorigenicity of neuroblastoma by Ackermann, Sandra, Kocak, Hayriye, Hero, Barbara, Ehemann, Volker, Kahlert, Yvonne, Oberthuer, André, Roels, Frederik, Theißen, Jessica, Odenthal, Margarete, Berthold, Frank, Fischer, Matthias

“…Segmental genomic copy number alterations, such as loss of 11q or 3p and gain of 17q, are well established markers of poor outcome in neuroblastoma, and have…”
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High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma by SCHULTE, Johannes H, BACHMANN, Hagen S, VANDESOMPELE, Jo, SPELEMAN, Frank, BERTHOLD, Frank, EGGERT, Angelika, BRORS, Benedikt, HERO, Barbara, SCHRAMM, Alexander, FISCHER, Matthias, BROCKMEYER, Bent, DEPRETER, Katleen, OBERTHÜR, André, ACKERMANN, Sandra, KAHLERT, Yvonne, PAJTLER, Kristian, THEISSEN, Jessica, WESTERMANN, Frank

“…Genomic alterations of the anaplastic lymphoma kinase (ALK) gene have been postulated to contribute to neuroblastoma pathogenesis. This study aimed to…”
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Age-dependent accumulation of genomic aberrations and deregulation of cell cycle and telomerase genes in metastatic neuroblastoma by Coco, Simona, Theissen, Jessica, Scaruffi, Paola, Stigliani, Sara, Moretti, Stefano, Oberthuer, André, Valdora, Francesca, Fischer, Matthias, Gallo, Fabio, Hero, Barbara, Bonassi, Stefano, Berthold, Frank, Tonini, Gian Paolo

“…About 50% of children with neuroblastoma (NB) show a metastatic disease and have a poor prognosis. However, disease progression is greatly variable and depends…”
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Prognostic Impact of Gene Expression–Based Classification for Neuroblastoma by OBERTHUER, André, HERO, Barbara, JANOUEIX-LEROSEY, Isabelle, DELATTRE, Olivier, SCHLEIERMACHER, Gudrun, VANDESOMPELE, Jo, VERMEULEN, Joëlle, SPELEMAN, Frank, NOGUERA, Rosa, PIQUERAS, Marta, BENARD, Jean, VALENT, Alexander, BERTHOLD, Frank, AVIGAD, Smadar, YANIV, Isaac, WEBER, Axel, CHRISTIANSEN, Holger, GRUNDY, Richard G, SCHARDT, Katharina, SCHWAB, Manfred, EILS, Roland, WARNAT, Patrick, KADERALI, Lars, JURAEVA, Dilafruz, SIMON, Thorsten, DECAROLIS, Boris, THEISSEN, Jessica, WESTERMANN, Frank, BRORS, Benedikt, FISCHER, Matthias, FALDUM, Andreas, KAHLERT, Yvonne, ASGHARZADEH, Shahab, SEEGER, Robert, SCARUFFI, Paola, PAOLO TONINI, Gian

“…To evaluate the impact of a predefined gene expression-based classifier for clinical risk estimation and cytotoxic treatment decision making in neuroblastoma…”
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Chromosome 17/17q gain and unaltered profiles in high resolution array-CGH are prognostically informative in neuroblastoma by Theissen, Jessica, Oberthuer, Andre, Hombach, Anja, Volland, Ruth, Hertwig, Falk, Fischer, Matthias, Spitz, Ruediger, Zapatka, Marc, Brors, Benedikt, Ortmann, Monika, Simon, Thorsten, Hero, Barbara, Berthold, Frank

“…The prognostic relevance of chromosome 17 gain in neuroblastoma is still discussed. This investigation specifies the frequency, type, size, and transcriptional…”
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A method for finding consensus breakpoints in the cancer genome from copy number data by Toloşi, Laura, Theißen, Jessica, Halachev, Konstantin, Hero, Barbara, Berthold, Frank, Lengauer, Thomas

“…Recurrent DNA breakpoints in cancer genomes indicate the presence of critical functional elements for tumor development. Identifying them can help determine…”
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Publisher Correction: Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma by Koche, Richard P., Rodriguez-Fos, Elias, Helmsauer, Konstantin, Burkert, Martin, MacArthur, Ian C., Maag, Jesper, Chamorro, Rocio, Munoz-Perez, Natalia, Puiggròs, Montserrat, Garcia, Heathcliff Dorado, Bei, Yi, Röefzaad, Claudia, Bardinet, Victor, Szymansky, Annabell, Winkler, Annika, Thole, Theresa, Timme, Natalie, Kasack, Katharina, Fuchs, Steffen, Klironomos, Filippos, Thiessen, Nina, Blanc, Eric, Schmelz, Karin, Künkele, Annette, Hundsdörfer, Patrick, Rosswog, Carolina, Theissen, Jessica, Beule, Dieter, Deubzer, Hedwig, Sauer, Sascha, Toedling, Joern, Fischer, Matthias, Hertwig, Falk, Schwarz, Roland F., Eggert, Angelika, Torrents, David, Schulte, Johannes H., Henssen, Anton G.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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High Genomic Instability Predicts Survival in Metastatic High-Risk Neuroblastoma by Stigliani, Sara, Coco, Simona, Moretti, Stefano, Oberthuer, Andrè, Fischer, Mattias, Theissen, Jessica, Gallox, Fabio, Garavent, Alberto, Berthold, Frank, Bonassi, Stefano, Tonini, Gian Paolo, Scaruffi, Paola

“…Abstract We aimed to identify novel molecular prognostic markers to better predict relapse risk estimate for children with high-risk (HR) metastatic…”
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Heterogeneity of the MYCN Oncogene in Neuroblastoma by THEISSEN, Jessica, BOENSCH, Marc, WESTERMANN, Frank, BERTHOLD, Frank, HERO, Barbara, SPITZ, Ruediger, BETTS, David, STEGMAIER, Sabine, CHRISTIANSEN, Holger, NIGGLI, Felix, SCHILLING, Freimut, SCHWAB, Manfred, SIMON, Thorsten

“…Purpose: MYCN amplification is an important therapy-stratifying marker in neuroblastoma. Fluorescence in situ hybridization with signal detection on the…”
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FOXP1inhibits cell growth and attenuates tumorigenicity of neuroblastoma by Ackermann, Sandra, Kocak, Hayriye, Hero, Barbara, Ehemann, Volker, Kahlert, Yvonne, Oberthuer, André, Roels, Frederik, Theißen, Jessica, Odenthal, Margarete, Berthold, Frank, Fischer, Matthias

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Molecular characterization and classification of neuroblastoma by Oberthuer, André, Theissen, Jessica, Westermann, Frank, Hero, Barbara, Fischer, Matthias

“…For many decades, neuroblastoma has remained a challenging disease for both clinicians and researchers. Now, techniques that efficiently specify both…”
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Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma by Koche, Richard P., Rodriguez-Fos, Elias, Helmsauer, Konstantin, Burkert, Martin, MacArthur, Ian C., Maag, Jesper, Chamorro, Rocio, Munoz-Perez, Natalia, Puiggròs, Montserrat, Dorado Garcia, Heathcliff, Bei, Yi, Röefzaad, Claudia, Bardinet, Victor, Szymansky, Annabell, Winkler, Annika, Thole, Theresa, Timme, Natalie, Kasack, Katharina, Fuchs, Steffen, Klironomos, Filippos, Thiessen, Nina, Blanc, Eric, Schmelz, Karin, Künkele, Annette, Hundsdörfer, Patrick, Rosswog, Carolina, Theissen, Jessica, Beule, Dieter, Deubzer, Hedwig, Sauer, Sascha, Toedling, Joern, Fischer, Matthias, Hertwig, Falk, Schwarz, Roland F., Eggert, Angelika, Torrents, David, Schulte, Johannes H., Henssen, Anton G.

“…Extrachromosomal circularization of DNA is an important genomic feature in cancer. However, the structure, composition and genome-wide frequency of…”
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Genomic ALK alterations in primary and relapsed neuroblastoma by Rosswog, Carolina, Fassunke, Jana, Ernst, Angela, Schömig-Markiefka, Birgid, Merkelbach-Bruse, Sabine, Bartenhagen, Christoph, Cartolano, Maria, Ackermann, Sandra, Theissen, Jessica, Blattner-Johnson, Mirjam, Jones, Barbara, Schramm, Kathrin, Altmüller, Janine, Nürnberg, Peter, Ortmann, Monika, Berthold, Frank, Peifer, Martin, Büttner, Reinhard, Westermann, Frank, Schulte, Johannes H., Simon, Thorsten, Hero, Barbara, Fischer, Matthias

“…Background Genomic alterations of the anaplastic lymphoma kinase gene ( ALK ) occur recurrently in neuroblastoma, a pediatric malignancy of the sympathetic…”
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Comparison of RNA-seq and microarray-based models for clinical endpoint prediction by Zhang, Wenqian, Yu, Ying, Hertwig, Falk, Thierry-Mieg, Jean, Zhang, Wenwei, Thierry-Mieg, Danielle, Wang, Jian, Furlanello, Cesare, Devanarayan, Viswanath, Cheng, Jie, Deng, Youping, Hero, Barbara, Hong, Huixiao, Jia, Meiwen, Li, Li, Lin, Simon M, Nikolsky, Yuri, Oberthuer, André, Qing, Tao, Su, Zhenqiang, Volland, Ruth, Wang, Charles, Wang, May D, Ai, Junmei, Albanese, Davide, Asgharzadeh, Shahab, Avigad, Smadar, Bao, Wenjun, Bessarabova, Marina, Brilliant, Murray H, Brors, Benedikt, Chierici, Marco, Chu, Tzu-Ming, Zhang, Jibin, Grundy, Richard G, He, Min Max, Hebbring, Scott, Kaufman, Howard L, Lababidi, Samir, Lancashire, Lee J, Li, Yan, Lu, Xin X, Luo, Heng, Ma, Xiwen, Ning, Baitang, Noguera, Rosa, Peifer, Martin, Phan, John H, Roels, Frederik, Rosswog, Carolina, Shao, Susan, Shen, Jie, Theissen, Jessica, Tonini, Gian Paolo, Vandesompele, Jo, Wu, Po-Yen, Xiao, Wenzhong, Xu, Joshua, Xu, Weihong, Xuan, Jiekun, Yang, Yong, Ye, Zhan, Dong, Zirui, Zhang, Ke K, Yin, Ye, Zhao, Chen, Zheng, Yuanting, Wolfinger, Russell D, Shi, Tieliu, Malkas, Linda H, Berthold, Frank, Wang, Jun, Tong, Weida, Shi, Leming, Peng, Zhiyu, Fischer, Matthias

“…Gene expression profiling is being widely applied in cancer research to identify biomarkers for clinical endpoint prediction. Since RNA-seq provides a powerful…”
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Genomic Profiles of Neuroblastoma Associated With Opsoclonus Myoclonus Syndrome by Hero, Barbara, Clement, Nathalie, Øra, Ingrid, Pierron, Gaelle, Lapouble, Eve, Theissen, Jessica, Pasqualini, Claudia, Valteau-Couanet, Dominique, Plantaz, Dominique, Michon, Jean, Delattre, Olivier, Tardieu, Marc, Schleiermacher, Gudrun

“…Opsoclonus myoclonus syndrome (OMS), often called "dancing eyed syndrome," is a rare neurological condition associated with neuroblastoma in the majority of…”
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Abstract LB-290: Multiple distinct mechanisms disrupt let-7 miRNA biogenesis and function in neuroblastoma by Powers, John T., Tsanov, Kaloyan M., Roles, Frederik, Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theissen, Jessica, LaPier, Grace S., Pearson, Dan S., Berthold, Frank, Daley, George Q.

“…Abstract The let-7 microRNA family are known tumor suppressors often deregulated in cancer, yet the underlying mechanisms of let-7 disruption remain poorly…”
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