Search Results - "Thege, Fredrik I"

Microfluidic immunocapture of circulating pancreatic cells using parallel EpCAM and MUC1 capture: characterization, optimization and downstream analysis by Thege, Fredrik I, Lannin, Timothy B, Saha, Trisha N, Tsai, Shannon, Kochman, Michael L, Hollingsworth, Michael A, Rhim, Andrew D, Kirby, Brian J

“…We have developed and optimized a microfluidic device platform for the capture and analysis of circulating pancreatic cells (CPCs) and pancreatic circulating…”
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Acquired chemoresistance drives spatial heterogeneity, chemoprotection and collective migration in pancreatic tumor spheroids by Thege, Fredrik I, Cardle, Ian I, Gruber, Conor N, Siemann, Megan J, Cong, Sophie, Wittmann, Katharina, Love, Justin, Kirby, Brian J

“…Tumors display rich cellular heterogeneity and typically consist of multiple co-existing clones with distinct genotypic and phenotypic characteristics. The…”
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A Programmable In Vivo CRISPR Activation Model Elucidates the Oncogenic and Immunosuppressive Functions of MYC in Lung Adenocarcinoma by Thege, Fredrik I, Rupani, Dhwani N, Barathi, Bhargavi Brahmendra, Manning, Sara L, Maitra, Anirban, Rhim, Andrew D, Wörmann, Sonja M

“…Conventional genetically engineered mouse models (GEMM) are time-consuming, laborious, and offer limited spatiotemporal control. Here, we describe the…”
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Detection of Circulating Pancreas Epithelial Cells in Patients With Pancreatic Cystic Lesions by Rhim, Andrew D, Thege, Fredrik I, Santana, Steven M, Lannin, Timothy B, Saha, Trisha N, Tsai, Shannon, Maggs, Lara R, Kochman, Michael L, Ginsberg, Gregory G, Lieb, John G, Chandrasekhara, Vinay, Drebin, Jeffrey A, Ahmad, Nuzhat, Yang, Yu–Xiao, Kirby, Brian J, Stanger, Ben Z

“…Hematogenous dissemination is thought to be a late event in cancer progression. We recently showed in a genetic model of pancreatic ductal adenocarcinoma that…”
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Comparison and optimization of machine learning methods for automated classification of circulating tumor cells by Lannin, Timothy B., Thege, Fredrik I., Kirby, Brian J.

“…Advances in rare cell capture technology have made possible the interrogation of circulating tumor cells (CTCs) captured from whole patient blood. However,…”
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Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of the Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential by Sans, Marta, Makino, Yuki, Min, Jimin, Rajapakshe, Kimal I, Yip-Schneider, Michele, Schmidt, C Max, Hurd, Mark W, Burks, Jared K, Gomez, Javier A, Thege, Fredrik I, Fahrmann, Johannes F, Wolff, Robert A, Kim, Michael P, Guerrero, Paola A, Maitra, Anirban

“…Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are bona fide precursor lesions of pancreatic ductal adenocarcinoma (PDAC). The most common…”
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Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling by Rupani, Dhwani N, Thege, Fredrik I, Chandra, Vidhi, Rajaei, Hajar, Cowan, Robert W, Wörmann, Sonja M, Le Roux, Olivereen, Malaney, Prerna, Manning, Sara L, Hashem, Jack, Bailey-Lundberg, Jennifer, Rhim, Andrew D, McAllister, Florencia

“…Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA-binding protein that deaminates adenosine (A) to inosine (I). A-to-I editing alters post-transcriptional…”
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anti-EGFR capture mitigates EMT- and chemoresistance-associated heterogeneity in a resistance-profiling CTC platform by Thege, Fredrik I., Gruber, Conor N., Cardle, Ian I., Cong, Sophie H., Lannin, Timothy B., Kirby, Brian J.

“…Capture and analysis of circulating tumor cells (CTCs) holds promise for diagnosing and guiding treatment of pancreatic cancer. To accurately monitor disease…”
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APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis by Wörmann, Sonja M, Zhang, Amy, Thege, Fredrik I, Cowan, Robert W, Rupani, Dhwani N, Wang, Runsheng, Manning, Sara L, Gates, Chris, Wu, Weisheng, Levin-Klein, Rena, Rajapakshe, Kimal I, Yu, Meifang, Multani, Asha S, Kang, Ya'an, Taniguchi, Cullen M, Schlacher, Katharina, Bellin, Melena D, Katz, Matthew H G, Kim, Michael P, Fleming, Jason B, Gallinger, Steven, Maddipati, Ravikanth, Harris, Reuben S, Notta, Faiyaz, Ross, Susan R, Maitra, Anirban, Rhim, Andrew D

“…Despite efforts in understanding its underlying mechanisms, the etiology of chromosomal instability (CIN) remains unclear for many tumor types. Here, we…”
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Abstract PR-15: Identifying synergistic combinations with KRAS inhibition in PDAC by Thege, Fredrik I, Hoskins, Amber, Woermann, Sonja M, Maitra, Anirban

“…Abstract Background: To date, targeted therapies have largely failed in eliciting sustained responses in advanced pancreatic ductal adenocarcinoma (PDAC)…”
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Abstract C057: Delineating tissue-specific oncogene selection with autochthonous CRISPR activation screening by Thege, Fredrik I., Woermann, Sonja M., Maitra, Anirban

“…Abstract Background: While the genetic landscapes of pancreatic ductal adenocarcinoma (PDAC) and non-small cell lung cancer (NSCLC) are well described, the…”
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Abstract C55: Mapping the pharmacotranscriptomic landscape of pancreatic circulating tumor cell organoids by Thege, Fredrik I., Barathi, Bhargavi B., Rupani, Dhwani N., Woermann, Sonja M., Rhim, Andrew D.

“…Abstract Introduction: Pancreatic cancer is characterized by early metastasis and resistance to chemotherapy. To elucidate the transcriptional reprogramming…”
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Abstract 1506: APOBEC3A a causative agent in cancer-related chromosomal instability and STING driven metastasis by Woermann, Sonja Maria, Zhang, Amy, Thege, Fredrik I., Gates, Chris, Harris, Reuben S., Ross, Susan R., Notta, Faiyaz, Maitra, Anirban, Rhim, Andrew D.

“…Abstract Chromosomal instability (CIN), a hallmark of cancer, has been associated with a highly metastatic phenotype in numerous cancers. Mechanisms by which…”
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Abstract PR-13: Disruption of sulfatide metabolism by targeting UGT8 is an actionable metabolic vulnerability for pancreatic cancer early interception by Ballarò, Riccardo, Chen, Yihui, Thege, Fredrik I, Dou, Rongzhang, Min, Jimin, Yip-Schneider, Michele, Zhang, Jianjun, Wu, Ranran, Irajizad, Ehsan, Makino, Yuki, Rajapakshe, Kimal I, Hurd, Mark W, León-Letelier, Ricardo A, Ostrin, Edwin, Vykoukal, Jody, Dennison, Jennifer B, Do, Kim-Anh, Hanash, Samir, Wolff, Robert A, Guerrero, Paola A, Kim, Michael P, Schmidt, C Max, Maitra, Anirban, Fahrmann, Johannes F

“…Abstract The existence of asymptomatic precursor lesions that are known to predate invasive pancreatic ductal adenocarcinoma (PDAC) by years provides a…”
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