Search Results - "Theelen, Thomas L."

Differential regulation of angiogenic cellular processes and claudin-5 by histamine and VEGF via PI3K-signaling, transcription factor SNAI2 and interleukin-8 by Laakkonen, Johanna P., Lappalainen, Jari P., Theelen, Thomas L., Toivanen, Pyry I., Nieminen, Tiina, Jauhiainen, Suvi, Kaikkonen, Minna U., Sluimer, Judith C., Ylä-Herttuala, Seppo

“…Aims Histamine and vascular endothelial growth factor A (VEGF) are central regulators in vascular pathologies. Their gene regulation leading to vascular…”
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Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia by Marsch, Elke, Demandt, Jasper A F, Theelen, Thomas L, Tullemans, Bibian M E, Wouters, Kristiaan, Boon, Mariëtte R, van Dijk, Theo H, Gijbels, Marion J, Dubois, Ludwig J, Meex, Steven J R, Mazzone, Massimiliano, Hung, Gene, Fisher, Edward A, Biessen, Erik A L, Daemen, Mat J A P, Rensen, Patrick C N, Carmeliet, Peter, Groen, Albert K, Sluimer, Judith C

“…Normalization of hypercholesterolaemia, inflammation, hyperglycaemia, and obesity are main desired targets to prevent cardiovascular clinical events. Here we…”
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Reversal of Hypoxia in Murine Atherosclerosis Prevents Necrotic Core Expansion by Enhancing Efferocytosis by Marsch, Elke, Theelen, Thomas L, Demandt, Jasper A.F, Jeurissen, Mike, van Gink, Mathijs, Verjans, Robin, Janssen, Anique, Cleutjens, Jack P, Meex, Steven J.R, Donners, Marjo M, Haenen, Guido R, Schalkwijk, Casper G, Dubois, Ludwig J, Lambin, Philippe, Mallat, Ziad, Gijbels, Marion J, Heemskerk, Johan W.M, Fisher, Edward A, Biessen, Erik A.L, Janssen, Ben J, Daemen, Mat J.A.P, Sluimer, Judith C

“…OBJECTIVE—Advanced murine and human plaques are hypoxic, but it remains unclear whether plaque hypoxia is causally related to atherogenesis. Here, we test the…”
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A Switch from Cell-Associated to Soluble PDGF-B Protects against Atherosclerosis, despite Driving Extramedullary Hematopoiesis by Tillie, Renée J H A, Theelen, Thomas L, van Kuijk, Kim, Temmerman, Lieve, de Bruijn, Jenny, Gijbels, Marion, Betsholtz, Christer, Biessen, Erik A L, Sluimer, Judith C

“…Platelet-derived growth factor B (PDGF-B) is a mitogenic, migratory and survival factor. Cell-associated PDGF-B recruits stabilizing pericytes towards blood…”
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Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice by Demandt, Jasper A F, van Kuijk, Kim, Theelen, Thomas L, Marsch, Elke, Heffron, Sean P, Fisher, Edward A, Carmeliet, Peter, Biessen, Erik A L, Sluimer, Judith C

“…Atherosclerosis is an important cause of clinical cardiovascular events. Atherosclerotic plaques are hypoxic, and reoxygenation improves plaque phenotype…”
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Deficiency of HIF1α in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice by Chaudhari, Sweena M, Sluimer, Judith C, Koch, Miriam, Theelen, Thomas L, Manthey, Helga D, Busch, Martin, Caballero-Franco, Celia, Vogel, Frederick, Cochain, Clément, Pelisek, Jaroslav, Daemen, Mat J, Lutz, Manfred B, Görlach, Agnes, Kissler, Stephan, Hermanns, Heike M, Zernecke, Alma

“…OBJECTIVE—Although immune responses drive the pathogenesis of atherosclerosis, mechanisms that control antigen-presenting cell (APC)–mediated immune activation…”
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Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling by van Kuijk, Kim, Demandt, Jasper A F, Perales-Patón, Javier, Theelen, Thomas L, Kuppe, Christoph, Marsch, Elke, de Bruijn, Jenny, Jin, Han, Gijbels, Marion J, Matic, Ljubica, Mees, Barend M E, Reutelingsperger, Chris P M, Hedin, Ulf, Biessen, Erik A L, Carmeliet, Peter, Baker, Andrew H, Kramann, Rafael K, Schurgers, Leon J, Saez-Rodriguez, Julio, Sluimer, Judith C

“…Abstract Aims Atherosclerotic plaque hypoxia is detrimental for macrophage function. Prolyl hydroxylases (PHDs) initiate cellular hypoxic responses, possibly…”
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Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis by Rademakers, Timo, van der Vorst, Emiel P. C., Daissormont, Isabelle T. M. N., Otten, Jeroen J. T., Theodorou, Kosta, Theelen, Thomas L., Gijbels, Marion, Anisimov, Andrey, Nurmi, Harri, Lindeman, Jan H. N., Schober, Andreas, Heeneman, Sylvia, Alitalo, Kari, Biessen, Erik A. L.

“…During plaque progression, inflammatory cells progressively accumulate in the adventitia, paralleled by an increased presence of leaky vasa vasorum. We here…”
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Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice by Theelen, Thomas L, Lappalainen, Jari P, Sluimer, Judith C, Gurzeler, Erika, Cleutjens, Jack P, Gijbels, Marion J, Biessen, Erik A.L, Daemen, Mat J.A.P, Alitalo, Kari, Ylä-Herttuala, Seppo

“…Abstract Objective Angiopoietin-2 (Ang-2) blocking agents are currently undergoing clinical trials for use in cancer treatment. Ang-2 has also been associated…”
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Quantification of Endothelial αv β3 Expression with High-Frequency Ultrasound and Targeted Microbubbles: In Vitro  and In Vivo Studies by Daeichin, Verya, Kooiman, Klazina, Skachkov, Ilya, Bosch, Johan G, Theelen, Thomas L, Steiger, Katja, Needles, Andrew, Janssen, Ben J, Daemen, Mat J.A.P, van der Steen, Antonius F.W, de Jong, Nico, Sluimer, Judith C

“…Abstract Angiogenesis is a critical feature of plaque development in atherosclerosis and might play a key role in both the initiation and later rupture of…”
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Cardiac Troponin T and I Release After a 30-km Run by Klinkenberg, Lieke J.J., Luyten, Peter, van der Linden, Noreen, Urgel, Kim, Snijders, Daniëlle P.C., Knackstedt, Christian, Dennert, Robert, Kietselaer, Bastiaan L.J.H., Mingels, Alma M.A., Cardinaels, Eline P.M., Peeters, Frederique E.C.M., van Suijlen, Jeroen D.E., ten Kate, Joop, Marsch, Elke, Theelen, Thomas L., Sluimer, Judith C., Wouters, Kristiaan, Bekers, Otto, Bekkers, Sebastiaan C.A.M., van Loon, Luc J.C., van Dieijen-Visser, Marja P., Meex, Steven J.R.

“…Prolonged endurance-type exercise is associated with elevated cardiac troponin (cTn) levels in asymptomatic recreational athletes. It is unclear whether…”
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The effect of prolonged dietary nitrate supplementation on atherosclerosis development by Marsch, Elke, Theelen, Thomas L, Janssen, Ben J.A, Briede, Jacco J, Haenen, Guido R, Senden, Joan M.G, van Loon, Lucas J.C, Poeze, Martijn, Bierau, Jörgen, Gijbels, Marion J, Daemen, Mat J.A.P, Sluimer, Judith C

“…Abstract Background Short term dietary nitrate or nitrite supplementation has nitric oxide (NO)-mediated beneficial effects on blood pressure and inflammation…”
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Author Correction: Ablation of CD8α+ dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice by Legein, Bart, Janssen, Edith M., Theelen, Thomas L., Gijbels, Marion J., Walraven, Joep, Klarquist, Jared S., Hennies, Cassandra M., Wouters, Kristiaan, Seijkens, Tom T. P., Wijnands, Erwin, Sluimer, Judith C., Lutgens, Esther, Zenke, Martin, Hildner, Kai, Biessen, Erik A. L., Temmerman, Lieve

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression by Theodorou, Kosta, van der Vorst, Emiel P. C., Gijbels, Marion J., Wolfs, Ine M. J., Jeurissen, Mike, Theelen, Thomas L., Sluimer, Judith C., Wijnands, Erwin, Cleutjens, Jack P., Li, Yu, Jansen, Yvonne, Weber, Christian, Ludwig, Andreas, Bentzon, Jacob F., Bartsch, Jörg W., Biessen, Erik A. L., Donners, Marjo M. P. C.

“…Although A Disintegrin And Metalloproteinase 8 (ADAM8) is not crucial for tissue development and homeostasis, it has been implicated in various inflammatory…”
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Ablation of CD8α+ dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice by Legein, Bart, Janssen, Edith M., Theelen, Thomas L., Gijbels, Marion J., Walraven, Joep, Klarquist, Jared S., Hennies, Cassandra M., Wouters, Kristiaan, Seijkens, Tom T.P., Wijnands, Erwin, Sluimer, Judith C., Lutgens, Esther, Zenke, Martin, Hildner, Kai, Biessen, Erik A.L., Temmerman, Lieve

“…Clinical complications of atherosclerosis are almost exclusively linked to destabilization of the atherosclerotic plaque. Batf3-dependent dendritic cells…”
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Cardiac Troponin T and I Release Following a 30 km Run by Klinkenberg, Lieke J.J., PhD, Luyten, Peter, MD, van der Linden, Noreen, MD, Urgel, Kim, MD, Snijders, Daniëlle P.C., BSc, Knackstedt, Christian, MD PhD, Dennert, Robert, MD PhD, Kietselaer, Bastiaan L.J.H., MD PhD, Mingels, Alma M.A., PhD, Cardinaels, Eline P.M., PhD, Peeters, Frederique E.C.M., MD, van Suijlen, Jeroen D.E., PhD, ten Kate, Joop, PhD, Marsch, Elke, MSc, Theelen, Thomas L., MSc, Sluimer, Judith C., PhD, Wouters, Kristiaan, PhD, Bekers, Otto, PhD, Bekkers, Sebastiaan C.A.M., MD PhD, van Loon, Luc J.C., PhD, van Dieijen-Visser, Marja P., PhD, Meex, Steven J.R., PhD

“…Abstract Prolonged endurance-type exercise is associated with elevated cardiac troponin (cTn) levels in asymptomatic recreational athletes. It is unclear…”
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Deficiency of HIF1alpha in antigen-presenting cells aggravates atherosclerosis and type 1 T helper cell responses in mice by Chaudhari, Sweena M., Sluimer, Judith C., Koch, Miriam, Theelen, Thomas L., Manthey, Helga D., Busch, Martin, Caballero-Franco, Celia, Vogel, Frederick, Cochain, Clement, Pelisek, Jaroslav, Daemen, Mat J., Lutz, Manfred B., Görlach, Agnes, Kissler, Stephan, Hermanns, Heike M., Zernecke, Alma

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Ablation of CD8[alpha]+ dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice by Legein, Bart, Janssen, Edith M, Theelen, Thomas L, Gijbels, Marion J, Walraven, Joep, Klarquist, Jared S, Hennies, Cassandra M, Wouters, Kristiaan, Seijkens, Tom Tp, Wijnands, Erwin, Sluimer, Judith C, Lutgens, Esther, Zenke, Martin, Hildner, Kai, Biessen, Erik Al, Temmerman, Lieve

“…Clinical complications of atherosclerosis are almost exclusively linked to destabilization of the atherosclerotic plaque. Batf3-dependent dendritic cells…”
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