Search Results - "Theberge, Charlie"
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Hypusine Signaling Promotes Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension
Published in American journal of respiratory and critical care medicine (01-06-2024)“…The ubiquitous polyamine spermidine is essential for cell survival and proliferation. One important function of spermidine is to serve as a substrate for…”
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Abstract 4143932: Exploring P300/CBP as therapeutic approach for right ventricular dysfunction in PAH
Published in Circulation (New York, N.Y.) (12-11-2024)“…Abstract only Pulmonary arterial hypertension (PAH) is characterized by vascular obstruction leading to progressive elevation of pulmonary artery pressure. In…”
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Abstract 15967: Unravelling the Role of Deoxyhypusine Synthase-Mediated Hypusination of eIF5A in Pulmonary Arterial Hypertension
Published in Circulation (New York, N.Y.) (07-11-2023)“…Abstract only Introduction: Pulmonary Arterial Hypertension (PAH) is characterized by progressive distal pulmonary arteries (PAs) obstruction leading to heart…”
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Abstract 18286: Histone Acetyltransferase P300/CBP in Pulmonary Arterial Hypertension and Associated Right Ventricular Failure
Published in Circulation (New York, N.Y.) (07-11-2023)“…Abstract only INTRODUCTION Pulmonary arterial hypertension (PAH) is defined by increased pulmonary artery (PA) pressure and vascular remodeling, partly due to…”
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Abstract 103: Acly Inhibition As A Novel Therapeutic Approach For Vascular Remodeling In Coronary Artery Disease
Published in Arteriosclerosis, thrombosis, and vascular biology (01-05-2024)“…Abstract only Coronary artery (CoA) disease (CAD) is characterized by neointimal hyperplasia (NH), which is driven by a cancer-like pro-proliferative phenotype…”
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Abstract 17430: Targeting DNA Hypermethylation With Hypomethylating Drugs: Implications for Pulmonary Arterial Hypertension
Published in Circulation (New York, N.Y.) (07-11-2023)“…Abstract only Introduction: Pulmonary arterial hypertension (PAH) is a lethal vasculopathy characterized by sustained vasoconstriction and remodeling of…”
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Abstract 17836: ATP Citrate Lyase Coordinates Lipid Synthesis and Expression Cell Cycle Regulating Genes to Promote Vascular Remodeling in Pulmonary Arterial Hypertension
Published in Circulation (New York, N.Y.) (07-11-2023)“…Abstract only INTRODUCTION: Pulmonary arterial hypertension (PAH) is characterized by progressive obliteration of distal pulmonary arteries (PAs) due to…”
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Abstract 15534: Identification of Narciclasine, a Potential Drug to Treat PAH by Unbiased Pharmaco-Transcriptomic Study
Published in Circulation (New York, N.Y.) (07-11-2023)“…Abstract only Introduction: Pulmonary arterial hypertension (PAH) is a life-threatening vascular disorder characterized by persistent vasoconstriction and…”
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Abstract 4139371: Treatment of pulmonary arterial hypertension by blocking integrin a5b1, a potential disease-modifying strategy
Published in Circulation (New York, N.Y.) (12-11-2024)“…Abstract only Introduction: Pulmonary arterial hypertension (PAH) is marked by pathological remodeling of distal arteries, driven by hyperplasia of pulmonary…”
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Abstract 4139465: Integrin α5β1 represents a novel therapeutic target to improve vascular remodeling in pulmonary arterial hypertension
Published in Circulation (New York, N.Y.) (12-11-2024)“…Abstract only Introduction: Pulmonary arterial hypertension (PAH) is characterized by progressive obstruction and decreased compliance of pulmonary arteries…”
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Abstract 4139022: Targeting Aurora Kinase B Improves Vascular Remodeling in Pulmonary Arterial Hypertension
Published in Circulation (New York, N.Y.) (12-11-2024)“…Abstract only Introduction: Pulmonary arterial hypertension (PAH) is a progressive and fatal disease characterized by pulmonary artery (PA) remodeling…”
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Abstract 4139456: Integrin α5β1 contributes to pathological remodeling of the right ventricle in pulmonary arterial hypertension
Published in Circulation (New York, N.Y.) (12-11-2024)“…Abstract only Introduction: Right ventricular (RV) function is an important prognosis factor in pulmonary arterial hypertension (PAH). In response to pressure…”
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Abstract 4136511: Targeting ATP Citrate Lyase: A Novel Therapeutic Strategy for Vascular Remodeling in Pulmonary Hypertension
Published in Circulation (New York, N.Y.) (12-11-2024)“…Abstract only Introduction: Pulmonary arterial hypertension (PAH) is a vascular remodeling disease characterized by a progressive obliteration of distal…”
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